The role of advanced maternal age and newborn sex in pregnancy outcome

Favilli, Alessandro; Pericoli, Silvia; Renzo, Gian Carlo Di; Gerli, Sandro

doi:10.1097/01.ebx.0000435384.90868.8d

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Of the included studies, three investigated post-partum hemorrhage, with a total of 103.123 participants (Tables 1 and 2) [20,42,71]. One study found an association with the presence of a female fetus.…”

Section: Fetal Sex and Post-partum Hemorrhagementioning

confidence: 99%

Fetal sex and maternal pregnancy outcomes: a systematic review and meta-analysis

et al. 2020

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Background: Since the placenta also has a sex, fetal sex-specific differences in the occurrence of placentamediated complications could exist. Objective: To determine the association of fetal sex with multiple maternal pregnancy complications. Search strategy: Six electronic databases Ovid MEDLINE, EMBASE, Cochrane Central, Web-of-Science, PubMed, and Google Scholar were systematically searched to identify eligible studies. Reference lists of the included studies and contact with experts were also used for identification of studies. Selection criteria: Observational studies that assessed fetal sex and the presence of maternal pregnancy complications within singleton pregnancies. Data collection and analyses: Data were extracted by 2 independent reviewers using a predesigned data collection form. Main results: From 6522 original references, 74 studies were selected, including over 12,5 million women. Male fetal sex was associated with term pre-eclampsia (pooled OR 1.07 [95%CI 1.06 to 1.09]) and gestational diabetes (pooled OR 1.04 [1.02 to 1.07]). All other pregnancy complications (i.e., gestational hypertension, total pre-eclampsia, eclampsia, placental abruption, and post-partum hemorrhage) tended to be associated with male fetal sex, except for preterm pre-eclampsia, which was more associated with female fetal sex. Overall quality of the included studies was good. Between-study heterogeneity was high due to differences in study population and outcome definition. Conclusion: This meta-analysis suggests that the occurrence of pregnancy complications differ according to fetal sex with a higher cardiovascular and metabolic load for the mother in the presence of a male fetus. Funding: None.

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Section: Fetal Sex and Post-partum Hemorrhagementioning

confidence: 99%