The role of advanced glycation end products in reproduction

Abashova, Elena I.; Yarmolinskaya, Maria I.; Bulgakova, Olga L.

doi:10.17116/repro20192504113

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…В-третьих, предшественники КПГ способны модифицировать функ-Основные механизмы повреждающего действия гипергликемии (объяснение в тексте) The main mechanisms of damaging effect of hyperglycemia (There are at least four main mechanisms by which hyperglycemia may cause damage to myocardium: activation of protein kinase C, formation of advanced glycation end products, activation of the hexosamine and polyol pathways of glucose metabolism) цию белков плазмы. После чего модифицированные циркулирующие белки связываются с рецепторами КПГ на соседних клетках, индуцируя таким образом опосредованную рецептором выработку активных форм кислорода, которая активирует ядерный фактор каппа-бета и экспрессию провоспалительных цитокинов и факторов роста [19,20].…”

Section: аналитический обзорunclassified

Pathogenic Mechanisms of Heart Failure in Patients With Type 2 Diabetes Mellitus

Ivanchenko,

Gagarina,

Goryanskaya

et al. 2023

Kompleks. probl. serdečno-sosud. zabol.

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Highlights The review presents up-to-date data on the contribution of type 2 diabetes mellitus to the development and progression of heart failure. The review highlights the key mechanisms of the pathogenesis of heart failure associated with changes in the energy metabolism of cardiomyocytes. AbstractType 2 diabetes mellitus is one of the main risk factors that significantly worsen the prognosis of heart failure and increases the probability of fatal cardiovascular events. The development of heart failure in diabetic patients involves a great number of risk factors for the rapid progression of atherosclerosis, as well as numerous combinations of neurohumoral, molecular and histological changes not associated with atherogenesis, which interconnection results in cardiovascular complications and heart failure decompensation. This review discusses the key mechanisms underlying development of heart failure in type 2 diabetes mellitus, in particular, special attention is paid to cardiomyocyte energy metabolism, cardiomyocyte death, and the significance of epigenetic factors in progression of chronic heart failure.

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Section: аналитический обзорunclassified