The role of adiponectin multimers in anorexia nervosa

Amitani, Haruka; Asakawa, Akihiro; Ogiso, Kazuma; Nakahara, Toshihiro; Ushikai, Miharu; Haruta, Izumi; Koyama, Ken; Amitani, Marie; Cheng, Kai‐Chun; Inui, Akio

doi:10.1016/j.nut.2012.07.011

Cited by 29 publications

(24 citation statements)

References 39 publications

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“…Moreover, contrary to our findings, these researchers revealed that the weight restoration correlated positively with HMW adiponectin [18]. On the other hand, Amitani et al failed to find any significant differences when comparing levels of all adiponectin forms of AN individuals and the controls [27]. However, these authors reported that the HMW ratio (HMW to total adiponectin) was significantly lower and the percentage of low-molecularweight (LMW) to total adiponectin (% LMW) was significantly higher in the AN group compared with the control group.…”

Section: Prace Oryginalnecontrasting

confidence: 99%

“…However, there was a non-significant tendency towards higher values of adiponectin in AN women independently of the disease phase when compared to the healthy controls. These results are in agreement with those reported by Nogueira et al [26] and Amitani et al [27]. Moreover, in another study conducted by the group of Iwahashi, individuals diagnosed with AN showed a tendency towards higher adiponectin levels than in the control group.…”

Section: Prace Oryginalnesupporting

confidence: 93%

“…Generally, assessment of total adiponectin showed a bi-phasic pattern with a temporary increase in the levels of this adipokine observed at the beginning of treatment and a gradual decrease thereafter [18,27,33]. However, in the current PRACE ORYGINALNE study we did not find significant differences between adiponectin levels when comparing AN individuals before and after refeeding.…”

Section: Prace Oryginalnecontrasting

confidence: 78%

“…In addition, Amitani et al reported higher adiponectin concentration during the acute phase of disease in comparison with those of controls. They observed that these results were even enhanced when adiponectin levels were normalised for BMI [27].…”

Section: Prace Oryginalnementioning

confidence: 99%

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Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissuederived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay. Results: Leptin and free leptin index (FLI) were lowest in treatment-naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group. Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content. (Endokrynol Pol 2017; 68 (4): 422-429)

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Section: Prace Oryginalnecontrasting

confidence: 99%

Section: Prace Oryginalnesupporting

confidence: 93%

Section: Prace Oryginalnecontrasting

confidence: 78%

Section: Prace Oryginalnementioning

confidence: 99%

See 2 more Smart Citations

Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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“…Salani et al (2006) showed that the mean percentage of HMW adiponectin with respect to total serum adiponectin levels is roughly 60% for non-obese humans. The percentage of HMW adiponectin with respect to total serum adiponectin levels is roughly 70% for healthy rats (Amitani et al, 2013). The mean percentage of HMW adiponectin with respect to total serum adiponectin levels ranged from 80% to 95% for the samples used in this study.…”

Section: Discussionmentioning

confidence: 72%

Habitat effects on blood adiponectin isoforms in black bears.

Wood¹

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Lay SummaryAdiponectin is a hormone closely associated with symptoms of obesity and diabetes. This hormone has multiple forms: a low molecular weight form (LMW) and a high molecular weight form (HMW). Levels of the HMW form directly correlate to symptoms of the aforementioned conditions. Blood samples were taken from black bears of two different habitats in eastern Kentucky. One population from Pine Mountain (PM), and the other from Big South Fork (BSF). These populations were utilized under the assumption that they would differ in potential sources of nutrition. The PM population is located in an area with greater access to highly palatable and energy rich human refuse. Therefore, this population was thought more likely to have a poor diet compared to the BSF population, which was assumed to be more reliant on natural sources of nutrition. The adiponectin in the blood samples was separated into its two different forms and the concentrations of the two forms were compared between the two habitats. The concentrations of the adiponectin forms were also compared between sexes of the bears sampled.This study found that bears from PM had significantly higher concentrations of total adiponectin than bears from BSF. Male bears from PM had significantly higher levels of the HMW form, and lower levels of the LMW form, when compared to male bears from BSF. No other significant differences were found with respect to habitat or sex. This suggests that a significant difference does exist between the two habitats. Possible explanations for this difference may include effects of age, percent body fat, diet, and seasonality of hormones. HABITAT EFFECTS ON ADIPONECTIN ISOFORMS IN BEARS SummaryAdiponectin is a 244-amino acid protein hormone predominantly produced and secreted by white adipocytes. This hormone plays a variety of roles in the regulation of metabolic processes that may be involved in obesity and copathologies, such as diabetes and cardiovascular disease. Adiponectin is synthesized in white adipocytes as a 30 kilodalton (kDa) monomer. Post-translational modifications transform this monomer into higher molecular weight multimers, including hexamers (known as the low molecular weight form, LMW) and 12-18 unit oligomers (known as the high molecular weight form, HMW). Although both multimeric forms are found in circulation, it has been established that the LMW adiponectin isoform is found at very minute levels. Furthermore, changes in HMW adiponectin correlate more with changes in total serum adiponectin levels, suggesting the HMW isoform is more metabolically active in both human and animal models.Blood serum samples were obtained from two populations of radio-collared black bears (Ursus americanus) in Eastern Kentucky. HMW adiponectin was separated from LMW adiponectin utilizing a centrifugation protocol. Serum and isoform levels of adiponectin were determined with a sandwich ELISA (enzyme-linked immunosorbent assay) kit (Rat) from ALPCO Diagnostics. Mean ± standard error values for serum and isoform adiponectin levels...

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Adiponectin in anorexia nervosa and its modifiers: A meta‐regression study

Tural

Iosifescu

2022

Intl J Eating Disorders

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Objective: Adiponectin, which is secreted from adipose tissue, is a protein hormone.Although a large body of studies have found that circulating adiponectin levels increase in anorexia nervosa (AN) and caloric restriction, the effect of subtypes of AN and modifiers of adiponectin in AN are not yet known.Methods: A systematic search of electronic databases was performed using the search terms "adiponectin," "anorexia nervosa," and "eating disorder" up to January 2021. All studies published in peer-reviewed journals, which included cases and control groups, were selected. The main outcome was the pooled standardized mean difference (SMD) in adiponectin levels between cases and controls, using the random-effects model. Modifiers of SMD were tested via meta-regression. Heterogeneity and publication bias were evaluated.Results: Thirty-four studies met all eligibility criteria. The total sample of AN participants (Hedges' g = .765, p < .0001), and specifically the binge-eating/purging (Hedges' g = 1.211, p < .00001) and restrictive subtypes (Hedges' g = .913, p < .00001) of AN have increased adiponectin plasma levels compared with healthy controls. Meta-regression determined that insulin, IGF-1, BMI, triglyceride, resistin, glucose, IL-6 levels are significant modifiers of adiponectin levels.Discussion: Compared with controls, adiponectin levels are higher in AN overall, and specifically in the binge-eating/purging and the restrictive AN subtypes. Many of metabolic parameters of glucose metabolism and pro-inflammatory molecules modify the relationship between AN and adiponectin levels. Adipose tissue is important to maintain metabolic stability.Public Significance: Anorexia nervosa is a psychiatric disorder associated with a severe decrease in body weight and multiple metabolic abnormalities, including an increase in the hormone adiponectin. In this paper, we used meta-analysis, a powerful statistical method, to aggregate data from 34 rigorously selected research reports. This enabled us to understand the value of adiponectin to differentiate clinical subtypes of anorexia nervosa and the relations between adiponectin and other important metabolic parameters.

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The role of adiponectin multimers in anorexia nervosa

Cited by 29 publications

References 39 publications

Adipokine profile in patients with anorexia nervosa

Adipokine profile in patients with anorexia nervosa

Habitat effects on blood adiponectin isoforms in black bears.

Adiponectin in anorexia nervosa and its modifiers: A meta‐regression study

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