The role of adenosine A1 receptor on immune cells

Zhong, Lingyu; Qiao, Peng; Zeng, Xun

doi:10.1007/s00011-022-01607-w

Cited by 6 publications

(2 citation statements)

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“…Plasma levels of adenosine, known to be higher in cord blood than in adult blood [ 49 ] might also be increased in M+B- cord plasma in relation to placental inflammation [ 3 , 29 , 50 ]. Adenosine can inhibit NO production [ 49 , 51 , 52 , 53 ]. Accordingly, a higher adenosine amount might limit the early ability of M+B- monocytes to kill trypomastigotes before they escape into the cytoplasm, thereby increasing the number of cytoplasmic amastigotes at 22 h. In addition, other anti-inflammatory factors, such as cytokines produced by regulatory T cells and erythroid cells, are present in the cord plasma and not or at lower concentrations in adults [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Monocytes from Uninfected Neonates Born to Trypanosoma cruzi-Infected Mothers Display Upregulated Capacity to Produce TNF-α and to Control Infection in Association with Maternally Transferred Antibodies

Flores,

Alonso-Vega,

Hermann

et al. 2023

Pathogens

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Activated monocytes/macrophages that produce inflammatory cytokines and nitric oxide are crucial for controlling Trypanosoma cruzi infection. We previously showed that uninfected newborns from T. cruzi infected mothers (M+B- newborns) were sensitized to produce higher levels of inflammatory cytokines than newborns from uninfected mothers (M-B- newborns), suggesting that their monocytes were more activated. Thus, we wondered whether these cells might help limit congenital infection. We investigated this possibility by studying the activation status of M+B- cord blood monocytes and their ability to control T. cruzi in vitro infection. We showed that M+B- monocytes have an upregulated capacity to produce the inflammatory cytokine TNF-α and a better ability to control T. cruzi infection than M-B- monocytes. Our study also showed that T. cruzi-specific Abs transferred from the mother play a dual role by favoring trypomastigote entry into M+B- monocytes and inhibiting intracellular amastigote multiplication. These results support the possibility that some M+B- fetuses may eliminate the parasite transmitted in utero from their mothers, thus being uninfected at birth.

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Section: Discussionmentioning

confidence: 99%

Monocytes from Uninfected Neonates Born to Trypanosoma cruzi-Infected Mothers Display Upregulated Capacity to Produce TNF-α and to Control Infection in Association with Maternally Transferred Antibodies

Flores,

Alonso-Vega,

Hermann

et al. 2023

Pathogens

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“…Adenosine receptors (ARs) are members of the G protein-coupled receptors superfamily and play important roles in energy metabolism and immunity ( Luo et al, 2022 ; Nakamura et al, 2020 ). They are classified into four receptor types: A1R, A2AR, A2BR, and A3R ( Saini et al, 2022 ; Zhong, Peng & Zeng, 2022 ), among which A2BR is expressed in various cell types and requires higher adenosine concentration for activation ( Sun, Wang & Hao, 2022 ). Moreover, under A2BR deficiency, a mouse ischemic heart model showed an increased number of immune cells, including B cells, NK cells, and CD4 T-cells.…”

Section: Introductionmentioning

confidence: 99%

Co-inhibition of adenosine 2b receptor and programmed death-ligand 1 promotes the recruitment and cytotoxicity of natural killer cells in oral squamous cell carcinoma

Wang,

Yang

et al. 2023

PeerJ

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Adenosine promotes anti-tumor immune responses by modulating the functions of T-cells and natural killer (NK) cells in the tumor microenvironment; however, the role of adenosine receptors in the progression of oral squamous cell carcinoma (OSCC) and its effects on immune checkpoint therapy remain unclear. In this study, we obtained the tumor tissues from 80 OSCC patients admitted at the Shandong University Qilu Hospital between February 2014 and December 2016. Thereafter, we detected the expression of adenosine 2b receptor (A2BR) and programmed death-ligand 1 (PD-L1) using immunohistochemical staining and analyzed the association between their expression in different regions of the tumor tissues, such as tumor nest, border, and paracancer stroma. To determine the role of A2BR in PD-L1 expression, CAL-27 (an OSCC cell line) was treated with BAY60-6583 (an A2BR agonist), and PD-L1 expression was determined using western blot and flow cytometry. Furthermore, CAL-27 was treated with a nuclear transcription factor-kappa B (NF-κ B) inhibitor, PDTC, to determine whether A2BR regulates PD-L1 expression via the NF-κ B signaling pathway. Additionally, a transwell assay was performed to verify the effect of A2BR and PD-L1 on NK cell recruitment. The results of our study demonstrated that A2BR and PD-L1 are co-expressed in OSCC. Moreover, treatment with BAY60-6583 induced PD-L1 expression in the CAL-27 cells, which was partially reduced in cells pretreated with PDTC, suggesting that A2BR agonists induce PD-L1 expression via the induction of the NF-κ B signaling pathway. Furthermore, high A2BR expression in OSCC was associated with lower infiltration of NK cells. Additionally, our results demonstrated that treatment with MRS-1706 (an A2BR inverse agonist) and/or CD274 (a PD-L1-neutralizing antibody) promoted NK cell recruitment and cytotoxicity against OSCC cells. Altogether, our findings highlight the synergistic effect of co-inhibition of A2BR and PD-L1 in the treatment of OSCC via the modulation of NK cell recruitment and cytotoxicity.

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Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat

Majkutewicz,

Kurowska-Rucińska,

Ruciński

et al. 2024

Mol Neurobiol

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The role of adenosine A1 receptor on immune cells

Cited by 6 publications

References 97 publications

Monocytes from Uninfected Neonates Born to Trypanosoma cruzi-Infected Mothers Display Upregulated Capacity to Produce TNF-α and to Control Infection in Association with Maternally Transferred Antibodies

Monocytes from Uninfected Neonates Born to Trypanosoma cruzi-Infected Mothers Display Upregulated Capacity to Produce TNF-α and to Control Infection in Association with Maternally Transferred Antibodies

Co-inhibition of adenosine 2b receptor and programmed death-ligand 1 promotes the recruitment and cytotoxicity of natural killer cells in oral squamous cell carcinoma

Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat

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