The role of ADAR editing and nonsense-mediated decay in Parkinson’s Disease
Heather Milliken Mercer,
Aiswarya Mukundan Nair,
Ayesha Tariq
et al.
Abstract:Parkinson's Disease (PD) is a multifactorial disease with heterogenous phenotypes that vary across individuals, as well as by age and sex. Therefore, it is likely that multiple interacting factors, such as environmental influences and aging, as well as genetic factors, including dynamic RNA (ADAR, Adenosine Deaminases Acting on RNA) editing, may play a role in PD pathology. In this analysis of 317 transcriptomes of healthy controls, PD and prodromal patients aged 65 years or older, from Parkinson's Project Mar… Show more
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