The role of active muscle mass in determining the magnitude of peripheral fatigue during dynamic exercise

Rossman, Matthew J.; Garten, Ryan S.; Venturelli, Massimo; Amann, Markus; Richardson, Russell S.

doi:10.1152/ajpregu.00043.2014

Cited by 71 publications

(109 citation statements)

References 38 publications

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“…These observations underpin the notion that perceptual responses are set in anticipation, otherwise known as teleoanticipation (76), so that exercise terminates at a critical sensory tolerance limit (32,58,60,75). By limiting exercise tolerance, the sensory tolerance limit will, therefore, also mediate the degree of peripheral fatigue incurred, which is consistent with the findings of recent studies using the isolated knee extensor exercise model (10,68). We note, however, that the limit of cycling exercise tolerance during CYC and ARM-CYC was sometimes associated with submaximal RPE and dyspnea, suggesting that additional influences, such as psychological factors (15,54), were also mediating the limit of exercise tolerance.…”

Section: Discussionsupporting

confidence: 85%

“…This finding is similar to the observation of less peripheral fatigue incurred after high-intensity cycling exercise in severe hypoxia (FI O 2 0.10) compared with normoxia (8). The notion that peripheral fatigue is not critically regulated is also supported by two recent isolated muscle studies: Rossman et al (68) observed greater quadriceps muscle fatigue during single-leg compared with double-leg knee extensor exercise, whereas Amann et al (10) observed less quadriceps muscle fatigue during single-leg knee extensor exercise after fatiguing knee extensor exercise with the contralateral leg. The present study thus extends these observations to whole body exercise by providing novel evidence that peripheral fatigue is not independently regulated during highintensity fixed work-rate cycling exercise to volitional tolerance.…”

Section: Discussionsupporting

confidence: 83%

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Locomotor muscle fatigue is not critically regulated after prior upper body exercise

Johnson

Sharpe

Williams

et al. 2015

Journal of Applied Physiology

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This study examined the effects of prior upper body exercise on subsequent high-intensity cycling exercise tolerance and associated changes in neuromuscular function and perceptual responses. Eight men performed three fixed work-rate (85% peak power) cycling tests: 1) to the limit of tolerance (CYC); 2) to the limit of tolerance after prior high-intensity arm-cranking exercise (ARM-CYC); and 3) without prior exercise and for an equal duration as ARM-CYC (ISOTIME). Peripheral fatigue was assessed via changes in potentiated quadriceps twitch force during supramaximal electrical femoral nerve stimulation. Voluntary activation was assessed using twitch interpolation during maximal voluntary contractions. Cycling time during ARM-CYC and ISOTIME (4.33 ± 1.10 min) was 38% shorter than during CYC (7.46 ± 2.79 min) (P < 0.001). Twitch force decreased more after CYC (-38 ± 13%) than ARM-CYC (-26 ± 10%) (P = 0.004) and ISOTIME (-24 ± 10%) (P = 0.003). Voluntary activation was 94 ± 5% at rest and decreased after CYC (89 ± 9%, P = 0.012) and ARM-CYC (91 ± 8%, P = 0.047). Rating of perceived exertion for limb discomfort increased more quickly during cycling in ARM-CYC [1.83 ± 0.46 arbitrary units (AU)/min] than CYC (1.10 ± 0.38 AU/min, P = 0.003) and ISOTIME (1.05 ± 0.43 AU/min, P = 0.002), and this was correlated with the reduced cycling time in ARM-CYC (r = -0.72, P = 0.045). In conclusion, cycling exercise tolerance after prior upper body exercise is potentially mediated by central fatigue and intolerable levels of sensory perception rather than a critical peripheral fatigue limit.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 83%

Locomotor muscle fatigue is not critically regulated after prior upper body exercise

Johnson

Sharpe

Williams

et al. 2015

Journal of Applied Physiology

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“…Of note, these CTRL [PCr] and pH values at task failure are similar to previous reports using small muscle mass exercise (9, 11). These findings are consistent with the typically greater level of peripheral fatigue developed, and therefore intramuscular metabolic perturbation (7), during small muscle mass exercise compared to large muscle mass exercise (36, 37). Furthermore, the attenuation of group III/IV muscle afferent feedback did not alter the end-exercise intramuscular PCr depletion or pH in the current study (Figure 2), while this exacerbated the PCr depletion (~27 %) and pH during large muscle mass exercise (7).…”

Section: Discussionsupporting

confidence: 80%

“…Furthermore, the degree to which the group III/IV muscle afferents influence the physiological responses to exercise (i.e. circulatory and ventilatory) may differ with exercising muscle mass (1, 2, 36, 37). A small muscle mass exercise paradigm focused more on the muscle itself (i.e.…”

Section: Introductionmentioning

confidence: 99%

Bioenergetics and ATP Synthesis during Exercise

Broxterman

Layec

Hureau

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose To investigate the role of the group III/IV muscle afferents in the bioenergetics of exercising skeletal muscle beyond constraining the magnitude of metabolic perturbation. Methods Eight healthy men, performed intermittent isometric knee-extensor exercise to task failure at ~58% maximal voluntary contraction (MVC) under control conditions (CTRL) and with lumbar intrathecal fentanyl to attenuate group III/IV leg muscle afferents (FENT). Intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4−), adenosine triphosphate (ATP), and pH were determined using phosphorous magnetic resonance spectroscopy (31P-MRS). Results The magnitude of metabolic perturbation was significantly greater in FENT compared to CTRL for [Pi] (37.8 ± 16.8 vs. 28.6 ± 8.6 mM), [H2PO4−] (24.3 ± 12.2 vs. 17.9 ± 7.1 mM), and [ATP] (75.8 ± 17.5 vs. 81.9 ± 15.8 % of baseline), while there was no significant difference in [PCr] (4.5 ± 2.4 vs. 4.4 ± 2.3 mM) or pH (6.51 ± 0.10 vs. 6.54 ± 0.14). The rate of perturbation in [PCr], [Pi], [H2PO4−], and pH was significantly faster in FENT compared to CTRL. Oxidative ATP synthesis was not significantly different between conditions. However, anaerobic ATP synthesis, through augmented creatine kinase and glycolysis reactions, was significantly greater in FENT than CTRL, resulting in a significantly greater ATP cost of contraction (0.049 ± 0.016 vs. 0.038 ± 0.010 mM·min−1·N−1). Conclusion Not only do group III/IV muscle afferents constrain magnitude of perturbation in intramuscular Pi, H2PO4−, and ATP during small muscle mass exercise, but also appear to play a role in maintaining efficient skeletal muscle contractile function in men.

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“…Under normoxic conditions, studies have found greater reductions in potentiated quadriceps twitch force during single-leg knee extension to exhaustion compared to two-legged knee extension or cycling exercise (Rossman et al, 2012(Rossman et al, , 2014. From this, the authors concluded that the fatigue is predominately peripheral in origin during exercise involving smaller muscle mass.…”

Section: Peripheral Fatiguementioning

confidence: 99%

Fatigue and Exhaustion in Hypoxia: The Role of Cerebral Oxygenation

Fan

Kayser

2016

High Altitude Medicine & Biology

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Fan, Jui-Lin, and Bengt Kayser. Fatigue and exhaustion in hypoxia: the role of cerebral oxygenation. High Alt Med Biol. 17:72-84, 2016.-It is well established that ascent to high altitude is detrimental to one's aerobic capacity and exercise performance. However, despite more than a century of research on the effects of hypoxia on exercise performance, the underlying mechanisms remain incompletely understood. While the cessation of exercise, or the reduction of its intensity, at exhaustion, implies reduced motor recruitment by the central nervous system, the mechanisms leading up to this muscular derecruitment remain elusive. During exercise in normoxia and moderate hypoxia (∼1500-2500 m), peripheral fatigue and activation of muscle afferents probably play a major role in limiting exercise performance. Meanwhile, studies suggested that cerebral tissue deoxygenation may play a pivotal role in impairing aerobic capacity during exercise in more severe hypoxic conditions (∼4500-6000 m). However, recent studies using end-tidal CO2 clamping, to improve cerebral tissue oxygenation during exercise in hypoxia, failed to demonstrate an improvement in exercise performance. In light of these recent findings, which seem to contradict the hypothetical role of cerebral tissue deoxygenation as a performance limiting factor at high altitude, this short review aims to provide a critical reappraisal of the extant literature and ends exploring some potential avenues for further research in this field.

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The role of active muscle mass in determining the magnitude of peripheral fatigue during dynamic exercise

Abstract: Rossman MJ, Garten RS, Venturelli M, Amann M, Richardson RS. The role of active muscle mass in determining the magnitude of peripheral fatigue during dynamic exercise.

Cited by 71 publications

References 38 publications

Locomotor muscle fatigue is not critically regulated after prior upper body exercise

Locomotor muscle fatigue is not critically regulated after prior upper body exercise

Bioenergetics and ATP Synthesis during Exercise

Fatigue and Exhaustion in Hypoxia: The Role of Cerebral Oxygenation

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