The role of Acticoat™ with nanocrystalline silver in the management of burns

Dunn, Ken; Edwards-Jones, Valerie

doi:10.1016/s0305-4179(04)90000-9

Cited by 312 publications

(218 citation statements)

References 29 publications

Supporting

Mentioning

209

Contrasting

Unclassified

Order By: Relevance

“…Silver may also possess anti-inflammatory properties; for example, studies have shown increased neutrophil apoptosis, reduced matrix metalloproteinase activity, reduced tumor necrosis factor-alpha levels, and more rapid healing in wounds dressed with silver [15][16][17][18][19]. Silver must be in a soluble, uncharged (Ag 0 ) or metallic (Ag +1 ) form to provide these biological effects [7]. Silver nitrate, silver sulfadiazine, and nanocrystalline silver are FDA-approved antimicrobials that are used in the treatment of chronic wounds.…”

Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

“…For example, coating a medical device with silver may impart antimicrobial and anti-inflammatory properties. Silver has been used in medicine since the late nineteenth century, when Crede introduced 1% silver nitrate solution for preventing ocular infections in neonates [7]. Silver has several effects on microbial cells, including impeding the cytochrome respiratory chain, impeding the microbial electron transport system, and preventing DNA replication [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

View full text Add to dashboard Cite

Implants containing antimicrobial metals may reduce morbidity, mortality, and healthcare costs associated with medical device-related infections. We have deposited diamondlike carbonsilver (DLC-Ag), diamondlike carbon-platinum (DLC-Pt), and diamondlike carbon-silverplatinum (DLC-AgPt) thin films using a multicomponent target pulsed laser deposition process.Transmission electron microscopy of the DLC-silver and DLC-platinum composite films revealed that the silver and platinum self-assemble into nanoparticle arrays within the diamondlike carbon matrix. The diamondlike carbon-silver film possesses hardness and Young's modulus values of 37 GPa and 331 GPa, respectively. The diamondlike carbon-metal composite films exhibited passive behavior at open-circuit potentials. Low corrosion rates were observed during testing in a phosphate-buffered saline (PBS) electrolyte. In addition, the diamondlike carbon-metal composite films were found to be immune to localized corrosion below 1000 mV (SCE). DLC-silver-platinum films demonstrated exceptional antimicrobial properties against Staphylococcus bacteria. It is believed that a galvanic couple forms between platinum and silver, which accelerates silver ion release and provides more robust antimicrobial activity.Diamondlike carbon-silver-platinum films may provide unique biological functionalities and improved lifetimes for cardiovascular, orthopaedic, biosensor, and implantable microelectromechanical systems.

show abstract

Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

View full text Add to dashboard Cite

show abstract

“…4-prolonged topical application of silver sulfadiazine cream can induce argyria [24]. Argyria, a permanent disorder caused by silver deposition in the skin's micro-vessels in patients who are exposed to chronic silver toxicity [25,26], is only seen following large oral or inhalated intakes of silver dust or colloidal silver over extended period of time and has never been reported as a result of topical application [27]. 5-direct silver induced renal toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo studies have found no evidence for cytotoxicity [23]. Despite the fact that after decades of use, the evidence for cytotoxicity is not clear and silver sulfadiazine remains the main topical product used in burn units [27,29]. Various observer toxic effects confirm that this topical cream should not be used for long periods on extensive wounds [24].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats

2010

View full text Add to dashboard Cite

The purpose of this study was to further investigate that phenomenon and to explore the effect silver sulfadiazine on wound healing. Full-thickness burn wounds were created on the dorsum of Wistar albino rats under anesthesia. The wounds were treated with silver sulfadiazine and saline-soaked dressing for fourteen days, and then observed until healed. Wound surface area was measured each three days. Time to 50% and 90% healing was compared. No clinical infections occurred. Wound half-life and healing times were shortest in the saline-soaked group (P<0.0001) in full-thickness burns. Wound contraction was delayed by silver sulfadiazine. These data suggest that silver sulfadiazine retard burn wound healing. Infection control without delay of burn wound healing is most appealing and clinical trials are planned.

show abstract

Silver-Coated Endotracheal Tubes and Incidence of Ventilator-Associated Pneumonia

Kollef

2008

JAMA

451

259

View full text Add to dashboard Cite

ENTILATOR-ASSOCIATED PNEUmonia(VAP)isassociatedwith high morbidity, including increased length of hospital stay, health care costs, and infection with multidrug-resistant pathogens. 1-3 The condition usually occurs within 10 days after endotracheal intubation. 3,4 Reported rates vary by case mix, case definition, diagnostic procedures, and method of expressing the rate. 5 Conservative estimates of incidence ranged from 9% 3 to 18% 4 in largedatabasesofmechanicallyventilated patientsanddecreasedsubstantiallywhen the definition was changed from adjudicated radiographic, clinical, and bronchoscopic criteria 4 to rigorous microbiological criteria. 6 The etiology of VAP is likely related to colonization of the aerodigestive tract with pathogenic bacteria and to aspiration of contaminated secretions. 1,7 Prevention strategies often focus on modifiable risk factors for colonization and aspiration 7-12 and can successfully reduce For editorial comment see p 842. Author Affiliations and Members of the North American Silver-Coated Endotracheal Tube (NASCENT) Investigation Group are listed at the end of this article.

show abstract

The role of Acticoat™ with nanocrystalline silver in the management of burns

Cited by 312 publications

References 29 publications

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats

Silver-Coated Endotracheal Tubes and Incidence of Ventilator-Associated Pneumonia

Contact Info

Product

Resources

About