The role of acidic fibroblast growth factor in recovery of acoustic trauma

Sugahara, Kazuma; Shimogori, Hiroaki; Yamashita, Hiroshi

doi:10.1097/00001756-200110290-00030

Cited by 22 publications

(12 citation statements)

References 13 publications

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“…Free radical formation has been implicated in all. Interventions can be directed at preventing initial ROS formation and maintaining cochlear blood flow (as reported here and by others); alternative therapeutic interventions and strategies include neurotrophic growth factors [119][120][121][122], steroids [123,124], calcineurin inhibitors [125,126], caspase inhibitors [127][128][129][130][131][132], and Src protein tyrosine kinase (Src-PTK) inhibitors [133]. Each of these are at least partially effective in prevention of hearing loss and hair cell death; none of these strategies have alone been sufficiently effective.…”

Section: Discussionmentioning

confidence: 94%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

198

188

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Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days following noise exposure. Reduction in cochlear blood flow as a result of free radical formation has also been described. Here we report that the antioxidant agents, vitamins A, C, and E, act in synergy with magnesium to effectively prevent noise-induced trauma. Neither the antioxidant agents nor magnesium reliably reduced NIHL or sensory cell death with the doses we used when these agents were delivered alone. In combination, however, they were highly effective in reducing both hearing loss and cell death even with treatment initiated just one hour prior to noise exposure. This study supports roles for both free radical formation and noise-induced vasoconstriction in the onset and progression of NIHL. Identification of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss. Keywords cochlea; free radical; noise; hearing; antioxidant; vasodilation Mechanical destruction of cells in the organ of Corti was once assumed to be the primary cause of noise-induced hearing loss (NIHL) [1][2][3][4][5][6][7][8], with perhaps some effect of reduced blood flow to the inner ear [9][10][11][12][13][14][15][16][17][18]. We now know that another key factor is intense metabolic activity that results in production of excess free radicals [19][20][21][22][23] and lipid peroxidation products [24]. Noise-induced production of reactive oxygen species (ROS) in the cochlea has now been well characterized, and several recent reviews are available [25][26][27]. Mitochodrial dysfunction and ROS production have been implicated in numerous neurodegenerative syndromes and diseases [28-34, see 35,36]. The use of antioxidant agents holds significant therapeutic promise for many neurodegenerative processes [32,33,[37][38][39][40][41][42], and there is some suggestion that Correspondence to: C. G. Le Prell, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. Tel: +1-734-763-5104; fax +1-734-764-0014. E-mail address: colleeng@umich.edu. Disclosure. Dr. Miller is a founding member and Chairman of the Board of Directors at OtoMedicine, Inc., a company that has an option to license the intellectual property described in this report. Dr. Le Prell is a paid consultant to OtoMedicine, Inc. Drs. Miller and Le Prell have disclosed these relationships to the Medical School Conflict of Interest Board at the University of Michigan; conflict management plans including semi-annual review by the Board are in place.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publicatio...

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Section: Discussionmentioning

confidence: 94%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

198

188

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“…For example, FGF 2 prevents noise-induced hair cell death and NIHL in vivo in guinea pigs (Zhai et al, 2004). Acidic fibroblast growth factor (aFGF, or FGF 1 ) was similarly effective; delivered via osmotic mini-pump, it reduced PTS in guinea pigs (although TTS deficits were not reduced, an effect similar to that of antioxidant agents) (Sugahara et al, 2001). While the protective effects of FGF 1 /FGF 2 were not found in all studies (see Yamasoba et al, 2001;David et al, 2002), the effects of other NTF have generally been protective, with glial cell line derived neurotrophic factor (GDNF) (Ylikoski et al, 1998;Yamasoba et al, 1999) and NT3 (Shoji et al, 2000) shown to prevent noise-induced deficits in guinea pigs when infused chronically using osmotic mini-pumps.…”

Section: Growth Factorsmentioning

confidence: 99%

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss.

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“…Nerve growth factor (NGF), neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) promote SGN survival in numbers similar to predeafened states, whether they are infused into the cochlea individually, in combinations of two or more, before ototoxic damage or after deafening [Ernfors et al, 1996;Gillespie et al, 2003Gillespie et al, , 2004Miller et al, 1997;Shah et al, 1995;Shinohara et al, 2002;Staecker et al, 1996;Wise et al, 2005;Ylikoski et al, 1998]. In addition, HCs can be protected from cell death if NT-3, GDNF or fibroblast growth factor (FGF) is applied prior to or up to 2 h after noise or ototoxic insult [Keithley et al, 1998;Kuang et al, 1999;Ruan et al, 1999;Shoji et al, 2000a, b;Sugahara et al, 2001;Yamasoba et al, 2001;Zhai et al, 2002]. Current data indicate that neurotro-…”

mentioning

confidence: 99%

Inner Ear Therapy for Neural Preservation

2006

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A gradual loss of auditory neurons often occurs following sensorineural hearing loss. Since the cochlear implant must stimulate the remaining auditory neuron population, it would be beneficial to preserve as many auditory neurons as possible. Neurotrophic factors protect auditory neurons from degradation after sensorineural hearing loss in experimental animals, but have not yet been translated into the clinical setting. Current experimental and clinical techniques for drug delivery to the inner ear are examined in this review, covering the routes for drug delivery to the cochlea and the delivery systems used to introduce them. Duration of treatment, drug diffusion, effectiveness and safety are discussed with references to how they may be translated to the implementation of neurotrophic factor treatment for neural preservation.

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The role of acidic fibroblast growth factor in recovery of acoustic trauma

Cited by 22 publications

References 13 publications

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Inner Ear Therapy for Neural Preservation

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