The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid

Cebrián-Prats, Anna; Pinto, Alexandre V.; González‐Lafont, Àngels; Fernandes, Pedro A.; Lluch, José M.

doi:10.1039/d1ob01932e

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…The difference in the phenotypic effects of the two treatments may have been caused by their fundamentally different pharmacodynamic nature. Diclofenac, as an NSAID, has a direct, potent inhibitory effect on cyclooxygenase enzymes (PTGS1 and PTGS2), leading to noticeable changes in downstream signaling and metabolic cascades associated with SPM biosynthesis [ 27 , 63 , 64 ]. Following administration, an initial effect on early gene transcription continued over time.…”

Section: Discussionmentioning

confidence: 99%

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

et al. 2023

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Background Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation involves multiple cell types and various processes. We, therefore, investigated whether an immunomodulatory drug that acts simultaneously at multiple sites shows greater potential to resolve acute inflammation more effectively and with fewer side effects than a common anti-inflammatory drug developed as a small molecule for a single target. In this work, we used time-series gene expression profiles from a wound healing mouse model to compare the effects of Traumeel (Tr14), a multicomponent natural product, to diclofenac, a single component NSAID on inflammation resolution. Results We advance previous studies by mapping the data onto the “Atlas of Inflammation Resolution”, followed by in silico simulations and network analysis. We found that Tr14 acts primarily on the late phase of acute inflammation (during resolution) compared to diclofenac, which suppresses acute inflammation immediately after injury. Conclusions Our results provide new insights how network pharmacology of multicomponent drugs may support inflammation resolution in inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

et al. 2023

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“…In fact, after the discovery of resolvins, the missing link in understanding the spectrum of biological effects of omega‐3 PUFAs in a chronic inflammatory process was replenished. It is also important to understand that a significant contribution to the synthesis of endogenous resolvins from precursors (such as eicosapentaenoic acid and docosahexaenoic acid) is made by modulating COX‐2 activity under conditions of aspirin‐induced acetylation, which suggests the horizons for more effective combined use of omega‐3 fatty acids and aspirin 10,11 …”

Section: Introductionmentioning

confidence: 99%

“…It is also important to understand that a significant contribution to the synthesis of endogenous resolvins from precursors (such as eicosapentaenoic acid and docosahexaenoic acid) is made by modulating COX-2 activity under conditions of aspirin-induced acetylation, which suggests the horizons for more effective combined use of omega-3 fatty acids and aspirin. 10,11 As far as we know, this review is the first comprehensive metaanalysis to investigate the possible effects of the combined use of…”

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confidence: 99%

Adjunctive use of omega‐3 fatty acids in combination with low‐dose aspirin in periodontitis: Systematic review and meta‐analysis

Neprelyuk,

Zhad'ko,

Romanenko

et al. 2023

J of Periodontal Research

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Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega‐3 polyunsaturated fatty acids (PUFAs) in combination with low‐dose aspirin. This systematic review and meta‐analysis were performed to compare the standard treatment alone and adjunctive use of omega‐3 PUFAs in combination with low‐dose aspirin with or without standard treatment in patients with periodontitis. A systematic review of the literature was performed using MEDLINE/PubMed, Cochrane Central and Google Scholar databases. Selection criteria included the following: randomized controlled trials in subjects with periodontitis in the age group above 18 years old, with follow‐up periods ranging from 6 weeks to 6 months. The meta‐analysis was performed using standard methodological procedures according to Cochrane recommendations, including assessment of risk‐of‐bias and level of evidence (GRADE). Meta‐analysis was performed for such clinical outcomes as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP) and bleeding index (BI) based on data from seven randomized clinical trials conducted between 2010 and 2020. It was shown that adjunctive use of omega‐3 PUFAs in combination with low‐dose aspirin results in significant clinical improvement in PD, CAL and GI during both short and prolonged follow‐up periods. The use of omega‐3 PUFAs and low‐dose aspirin in periodontitis patients may be promising as an adjunct therapy, however, due to a limited number of patients and significant heterogeneity, further studies need to be conducted.

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Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans

Engert,

Ledderose,

Biniamin

et al. 2024

Brain, Behavior, and Immunity

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The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid

Abstract: Specialized pro-resolving lipid mediators (SPMs) are natural bioactive agents actively involved in inflammation resolution. SPMs act when uncontrolled inflammatory processes are developed, for instance, in patients of COVID-19 or other...

Cited by 5 publications

References 46 publications

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

Adjunctive use of omega‐3 fatty acids in combination with low‐dose aspirin in periodontitis: Systematic review and meta‐analysis

Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans

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