The role of ablation in the treatment of dysplastic Barrett’s esophagus

Abstract

Endoscopic eradication therapy for Barrett’s esophagus has been established as an effective management strategy for patients with Barrett’s esophagus with dysplasia and early esophageal cancer. Among the endoscopic therapies, ablation techniques such as radiofrequency ablation and cryoablation are effective primary treatment interventions with acceptable low complication rates forming the spectrum of a multimodal approach. Appropriate selection of patients, high-definition endoscopic evaluation, and dedicated histological assessment are important cornerstones to help navigate to the best effective treatment method. Carefully structured surveillance programs and preventive measures will be needed to provide long-term durability for maintaining complete remission.

Esophageal cancer

“…38 Ablative therapy, more useful after resection and for patients with Barrett esophagus, also can provide some relief but is associated with the need for more sessions compared with stent placement. 38,55 Screening methods About 60% of patients will have a concurrent diagnosis of Barrett esophagus and esophageal cancer, thus representing a gap in screening for Barrett esophagus. 56 Screening in moderate-and high-risk populations is key to prevention and early diagnosis.…”

“…This treatment, although rarely used, has proven long-term benefits, especially for patients with unresectable esophageal cancer 38. Ablative therapy, more useful after resection and for patients with Barrett esophagus, also can provide some relief but is associated with the need for more sessions compared with stent placement 38,55…”