The role of a drug-loaded poly (lactic co-glycolic acid) (PLGA) copolymer stent in the treatment of ovarian cancer

Wang, Yanqing; Qiao, Xiaoyin; Xiao, Yang; Yuan, Mengqin; Shu, Xian; Zhang, Li; Yang, Dongyong; Liu, Shiyi; Dai, Fangfang; Tan, Zhikai; Cheng, Yanxiang

doi:10.20892/j.issn.2095-3941.2019.0169

Cited by 17 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall performance of the drug‐loaded porous PLGA MS was thoroughly examined in cell assays. The combination index was measured and found to be similar to what we measured with the free drugs, but with slightly higher values, which may be due to the slow release of the drugs from the MS. [ 57 ] The slightly lower CI values of porous MS, compared with the non‐porous ones, were mainly due to different release patterns and rates from the PLGA matrix. Porous materials are characterized by open structures that allow a greater flow of liquid that can reach and dissolve the entrapped drugs into the medium more quickly, compared with the non‐porous MS (Figure 2d).…”

Section: Discussionmentioning

confidence: 99%

Drug‐Eluting Porous Embolic Microspheres for Trans‐Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer

Amoyav,

Bloom,

Goldstein

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Blockage of blood supply while administering chemotherapy to tumors, using trans‐arterial chemoembolization (TACE), is the most common treatment for intermediate and advanced‐stage unresectable Hepatocellular carcinoma (HCC). However, HCC is characterized by a poor prognosis and high recurrence rates (≈30%), partly due to a hypoxic pro‐angiogenic and pro‐cancerous microenvironment. This study investigates how modifying tissue stress while improving drug exposure in target organs may maximize the therapeutic outcomes. Porous degradable polymeric microspheres (MS) are designed to obtain a gradual occlusion of the hepatic artery that nourishes the liver, while enabling efficient drug perfusion to the tumor site. The fabricated porous MS are introduced intrahepatically and designed to release a combination therapy of Doxorubicin (DOX) and Tirapazamine (TPZ), which is a hypoxia‐activated prodrug. Liver cancer cell lines that are treated with the combination therapy under hypoxia reveal a synergic anti‐proliferation effect. An orthotopic liver cancer model, based on N1‐S1 hepatoma in rats, is used for the efficacy, biodistribution, and safety studies. Porous DOX‐TPZ MS are very effective in suppressing tumor growth in rats, and induction tissue necrosis is associated with high intratumor drug concentrations. Porous particles without drugs show some advantages over nonporous particles, suggesting that morphology may affect the treatment outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Drug‐Eluting Porous Embolic Microspheres for Trans‐Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer

Amoyav,

Bloom,

Goldstein

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Therefore, it is not necessary to find an appropriate individualized reference dose; however, CDDP does have certain side effects and is associated with drug resistance in clinical applications. Wang et al [ 33 ] used 3D printing technology to develop a drug-loaded stent by encapsulating CDDP in a PLGA stent, which was directly implanted near the tumor site. The drug-loaded stent had a high local drug-release capacity, which improved bioavailability, prolonged controlled drug release, and reduced side effects.…”

Section: Applications Of 3d Printing Technology In Obstetrics and Gyn...mentioning

confidence: 99%

3D Printing and Its Current Status of Application in Obstetrics and Gynecological Diseases

Zhang

2023

Bioengineering

View full text Add to dashboard Cite

3D printing technology is a novel method of utilizing computer-generated three-dimensional models for drawing, assembling special bioinks, and manufacturing artificial organs and biomedical products. In recent years, it has evolved into a relatively mature therapeutic approach and has been widely used in clinical and basic research. In the field of obstetrics and gynecology, 3D printing technology has been applied for various purposes, including disease diagnosis, treatment, pathogenesis research, and medical education. Notably, researchers have gained significant application experience in common gynecological and obstetrical disorders, such as intrauterine adhesions, uterine tumors, congenital malformations, and fetal congenital abnormalities. This review aims to provide a systematical summary of current research on the application of 3D bioprinting technology in the field of obstetrics and gynecology.

show abstract

“…Such a promising strategy can reduce the systemic side effects compared with the use of systemic cytotoxic drugs. 84 Likewise, 3D-printed hormone-eluted constructs were developed to provide personalized biodegradable implants for indicated hormonal therapies. 85 In uterine and cervical cancer, brachytherapy can be suboptimal in large tumors with extensive paravaginal or parametrial involvement.…”

Section: Therapeuticsmentioning

confidence: 99%

The Role of Three-dimensional Printed Models in Women’s Health

AlRawi,

Basha,

Elmeligy

et al. 2023

Womens Health (Lond Engl)

View full text Add to dashboard Cite

Three-dimensional printing is an innovative technology that has gained prominence in recent years due to its attractive features such as affordability, efficiency, and quick production. The technology is used to produce a three-dimensional model by depositing materials in layers using specific printers. In the medical field, it has been increasingly used in various specialties, including neurosurgery, cardiology, and orthopedics, most commonly for the pre-planning of complex surgeries. In addition, it has been applied in therapeutic treatments, patient education, and training wof medical professionals. In the field of obstetrics and gynecology, there is a limited number of studies in which three-dimensional printed models were applied. In this review, we aim to provide an overview of three-dimensional printing applications in the medical field, highlighting the few reported applications in obstetrics and gynecology. We also review all relevant studies and discuss the current challenges and limitations of adopting the technology in routine clinical practice. The technology has the potential to expand for wider applications related to women’s health, including patient counseling, surgical training, and medical education.

show abstract

The role of a drug-loaded poly (lactic co-glycolic acid) (PLGA) copolymer stent in the treatment of ovarian cancer

Cited by 17 publications

References 39 publications

Drug‐Eluting Porous Embolic Microspheres for Trans‐Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer

Drug‐Eluting Porous Embolic Microspheres for Trans‐Arterial Delivery of Dual Synergistic Anticancer Therapy for the Treatment of Liver Cancer

3D Printing and Its Current Status of Application in Obstetrics and Gynecological Diseases

The Role of Three-dimensional Printed Models in Women’s Health

Contact Info

Product

Resources

About