The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology

Sezin, Tanya; Selvakumar, Balachandar; Scheffold, Alexander

doi:10.1016/j.bbamcr.2021.119192

Cited by 8 publications

(6 citation statements)

References 202 publications

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“…ADAM10 and ADAM17 cleavage is necessary for activation, differentiation, and migration of helper T cells and their interaction with B lymphocytes, by affecting multiple target proteins, including CD40L, CD25, CD137, and CD154. In addition, ADAM17 reduces the expression of IFN-γ ( Lambrecht et al, 2018 ; Sezin et al, 2022 ). On the other hand, the ADAMTS proteases were as yet not extensively studied in the human immune system and if, then only in pathological settings.…”

Section: Components Contributing To Proteostasismentioning

confidence: 99%

Proteolysis dysfunction in the process of aging and age-related diseases

2022

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In this review, we discuss in detail the most relevant proteolytic systems that together with chaperones contribute to creating the proteostasis network that is kept in dynamic balance to maintain overall functionality of cellular proteomes. Data accumulated over decades demonstrate that the effectiveness of elements of the proteostasis network declines with age. In this scenario, failure to degrade misfolded or faulty proteins increases the risk of protein aggregation, chronic inflammation, and the development of age-related diseases. This is especially important in the context of aging-related modification of functions of the immune system.

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Section: Components Contributing To Proteostasismentioning

confidence: 99%

Proteolysis dysfunction in the process of aging and age-related diseases

2022

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“…This process is essential for maintaining Foxp3 expression in mature Treg cells. Phosphatase 2A (PP2A) is a negative regulator of IL-2 production in Teffs ( 64 ) and prevents IL-2Rβ from being clipped from the cell surface by restricting the activity of ADAM metallopeptidase domain 10 (ADAM10) in Tregs, thereby achieving effective IL-2R signaling and ultimately affecting Tregs ( 65 ).…”

Section: Treg-promoting Cytokinesmentioning

confidence: 99%

Regulation of Treg cells by cytokine signaling and co-stimulatory molecules

Zong,

Deng,

Chong

2024

Front. Immunol.

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CD4+CD25+Foxp3+ regulatory T cells (Tregs), a vital component of the immune system, are responsible for maintaining immune homeostasis and preventing excessive immune responses. This review explores the signaling pathways of the cytokines that regulate Treg cells, including transforming growth factor beta (TGF-β), interleukin (IL)-2, IL-10, and IL-35, which foster the differentiation and enhance the immunosuppressive capabilities of Tregs. It also examines how, conversely, signals mediated by IL-6 and tumor necrosis factor -alpha (TNF-α) can undermine Treg suppressive functions or even drive their reprogramming into effector T cells. The B7 family comprises indispensable co-stimulators for T cell activation. Among its members, this review focuses on the capacity of CTLA-4 and PD-1 to regulate the differentiation, function, and survival of Tregs. As Tregs play an essential role in maintaining immune homeostasis, their dysfunction contributes to the pathogenesis of autoimmune diseases. This review delves into the potential of employing Treg-based immunotherapy for the treatment of autoimmune diseases, transplant rejection, and cancer. By shedding light on these topics, this article aims to enhance our understanding of the regulation of Tregs by cytokines and their therapeutic potential for various pathological conditions.

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“…The results showed that nasal lavage fluid-derived sEVs from patients with NPs promote tube formation by human umbilical vein endothelial cells and increase vascular permeability compared with those from unaffected people. The main secreted substance detected in this experiment is a disintegrin and metalloproteinase-10 (ADAM-10) [ 73 ], which is a protease that promotes protein release and is related to angiogenesis and permeability [ 74 ]. Other studies have found that sEVs from patients with NPs can target VE-cadherin to regulate vascular permeability through miR-22-3p [ 75 ]; moreover, relevant studies suggest that such sEVs have a significant impact on angiogenesis [ 76 , 77 ].…”

Section: Relationship Between Nps and Secreted Sevsmentioning

confidence: 99%

The Role of Small Extracellular Vesicles and MicroRNAs in the Diagnosis and Treatment of Allergic Rhinitis and Nasal Polyps

Liu

Sha

Meng

et al. 2022

Mediators of Inflammation

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Allergic rhinitis and nasal polyps are common otorhinolaryngological diseases. Small extracellular vesicles and microRNAs have recently become major research topics of interest due to their key regulatory roles in cancer, inflammation, and various diseases. Although very detailed and in-depth studies on the pathogenesis and pathophysiology of allergic rhinitis and nasal polyps have been conducted, few studies have assessed the regulatory effects of exosomes and microRNAs on allergic rhinitis and nasal polyps. This paper reviews the studies on small extracellular vesicles and microRNAs in allergic rhinitis and nasal polyps conducted in recent years and focuses on the regulation of small extracellular vesicles and microRNAs in allergic rhinitis and nasal polyps with the aim of providing insights for the future diagnosis and treatment of allergic rhinitis and nasal polyps.

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The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology

Cited by 8 publications

References 202 publications

Proteolysis dysfunction in the process of aging and age-related diseases

Proteolysis dysfunction in the process of aging and age-related diseases

Regulation of Treg cells by cytokine signaling and co-stimulatory molecules

The Role of Small Extracellular Vesicles and MicroRNAs in the Diagnosis and Treatment of Allergic Rhinitis and Nasal Polyps

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