The role of 5‐lipoxygenase in Aggregatibacter actinomycetemcomitans‐induced alveolar bone loss

Abstract

In conclusion, LTB4 but not CysLTs is important for Aa-induced alveolar bone loss. Overall, LTB4 affects osteoclast differentiation and activity and is a key intermediate of PAF-induced osteoclastogenesis.

Using Genetics in Periodontal Disease to Justify Implant Failure in Down Syndrome Patients

“…This is supported by ALOX5 inhibition [ 16 , 17 ], where the inhibition of bone resorption has been observed via a significant reduction in the number of osteoclasts, as well as a decrease in the severity of the inflammation, due to a significant reduction in the number of polymorphonuclear (PMN) and mononuclear cells. This is associated with a discreet increase in IL-10, an anti-inflammatory cytokine, probably due to a lower level of the production of LTB4 [ 16 ], even in the presence of an infection with Aggregatibacter actinomycetemcomitans [ 17 ]. In our results, LTA4H was overexpressed, which could be understood as an increase in LTB4 in PD+IR+ patients compared with PD+IR-.…”

“…LTA4H takes part in chemotaxis, the production of reactive oxygen species, and in the production of IL1, IL6 and IFNG. LTB4 is augmented in crevicular fluid and in the saliva of patients with periodontal disease [ 16 ], and it is associated with a greater level of severity of the disease [ 17 ]. Likewise, it has been related to improvement in the differentiation and activity of osteoclasts that negatively affect bone turnover without the need to increase the number of osteoclasts.…”

“…Likewise, it has been related to improvement in the differentiation and activity of osteoclasts that negatively affect bone turnover without the need to increase the number of osteoclasts. It has also been related to reducing the differentiation and activity of osteoblasts, as well as improving the calcium flow [ 16 , 17 , 18 , 19 ]. This is supported by ALOX5 inhibition [ 16 , 17 ], where the inhibition of bone resorption has been observed via a significant reduction in the number of osteoclasts, as well as a decrease in the severity of the inflammation, due to a significant reduction in the number of polymorphonuclear (PMN) and mononuclear cells.…”

“…It has also been related to reducing the differentiation and activity of osteoblasts, as well as improving the calcium flow [ 16 , 17 , 18 , 19 ]. This is supported by ALOX5 inhibition [ 16 , 17 ], where the inhibition of bone resorption has been observed via a significant reduction in the number of osteoclasts, as well as a decrease in the severity of the inflammation, due to a significant reduction in the number of polymorphonuclear (PMN) and mononuclear cells. This is associated with a discreet increase in IL-10, an anti-inflammatory cytokine, probably due to a lower level of the production of LTB4 [ 16 ], even in the presence of an infection with Aggregatibacter actinomycetemcomitans [ 17 ].…”

Mecanismos intracelulares induzidos por leucotrienos durante a diferenciação osteogênica

“…Um recente estudo publicado mostrou que camundongos 5-LO KO não apresentaram perda óssea alveolar, demonstrando também um menor número de células TRAP-positivas nos tecidos periodontais, após a infecção com Aa (Aggregatibacter actinomycetemcomitans) (MADEIRA et al, 2017).…”