The role of 5-HT1A receptors of hippocampal CA1 region in anticonvulsant effects of low-frequency stimulation in amygdala kindled rats

Gharib, Alireza; Sayyahi, Zeinab; Komaki‬, Alireza; Barkley, Victoria; Sarihi, Abdolrahman; Mirnajafi‐Zadeh, Javad

doi:10.1016/j.physbeh.2018.08.025

Cited by 12 publications

(12 citation statements)

References 47 publications

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“…High frequency stimulation (HFS) was demonstrated to be more effective in reducing seizures and is often used in DBS therapies [ 21 , 22 ], but LFS also showed antiepileptic effect in a couple of human trials [ 23 , 24 ] and in several animal models of epilepsy [ 25 , 26 , 27 , 28 ]. LFS may be associated with reduced target tissue damage due to the smaller amount of stimulating current [ 29 , 30 ]. The underlying mechanisms of HFS vs. LFS induced seizure suppression are most likely different.…”

Section: Introductionmentioning

confidence: 99%

Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy

et al. 2020

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Temporal-lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was applied to different brain regions for patients with epilepsy; however, the mechanisms of action are not fully understood. Therefore, we tried to characterize the effect of amygdala DBS on hippocampal electrical activity in the lithium-pilocarpine model in male Wistar rats. After status epilepticus (SE) induction, seizure patterns were determined based on continuous video recordings. Recording electrodes were inserted in the left and right hippocampus and a stimulating electrode in the left basolateral amygdala of both Pilo and age-matched control rats 10 weeks after SE. Daily stimulation protocol consisted of 4 × 50 s stimulation trains (4-Hz, regular interpulse interval) for 10 days. The hippocampal electroencephalogram was analyzed offline: interictal epileptiform discharge (IED) frequency, spectral analysis, and phase-amplitude coupling (PAC) between delta band and higher frequencies were measured. We found that the seizure rate and duration decreased (by 23% and 26.5%) and the decrease in seizure rate correlated negatively with the IED frequency. PAC was elevated in epileptic animals and DBS reduced the pathologically increased PAC and increased the average theta power (25.9% ± 1.1 vs. 30.3% ± 1.1; p < 0.01). Increasing theta power and reducing the PAC could be two possible mechanisms by which DBS may exhibit its antiepileptic effect in TLE; moreover, they could be used to monitor effectiveness of stimulation.

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Section: Introductionmentioning

confidence: 99%

Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy

et al. 2020

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“…A common type of adult epilepsy is temporal lobe epilepsy (TLE). This epilepsy occurs with spontaneous seizures that originate from limbic structures of the temporal lobe (Spencer & Spencer, 1994;Gharib et al, 2018). The treatment of patients with TLE is difficult (Kwan & Sander, 2004).…”

Section: Epilepsymentioning

confidence: 99%

The effect of sodium channels on neurological/neuronal disorders: A systematic review

Bagheri

Haddadi

Saki

et al. 2021

Intl J of Devlp Neuroscience

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Neurological and neuronal disorders are associated with structural, biochemical, or electrical abnormalities in the nervous system. Many neurological diseases have not yet been discovered. Interventions used for the treatment of these disorders include avoidance measures, lifestyle changes, physiotherapy, neurorehabilitation, pain management, medication, and surgery. In the sodium channelopathies, alterations in the structure, expression, and function of voltage-gated sodium channels (VGSCs) are considered as the causes of neurological and neuronal diseases. Online databases, including Scopus, Science Direct, Google Scholar, and PubMed were assessed for studies published between 1977 and 2020 using the keywords of review, sodium channels blocker, neurological diseases, and neuronal diseases. VGSCs consist of one α subunit and two β subunits. These subunits are known to regulate the gating kinetics, functional characteristics, and localization of the ion channel. These channels are involved in cell migration, cellular connections, neuronal pathfinding, and neurite outgrowth. Through the VGSC, the action potential is triggered and propagated in the neurons. Action potentials are physiological functions and passage of impermeable ions. The electrophysiological properties of these channels and their relationship with neurological and neuronal disorders have been identified. Subunit mutations are involved in the development of diseases, such as epilepsy, multiple sclerosis, autism, and Alzheimer's disease. Accordingly, we conducted a review of the link between VGSCs and neurological and neuronal diseases. Also, novel therapeutic targets were introduced for future drug discoveries.

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“…After placing the rats in the middle of the apparatus, they were given time to explore for 10 minutes. A video camera was used to monitor the number of animals entering the center, spend time in the peripheral and central areas, and the overall distance traveled (Gharib et al, 2018;Etaee et al, 2019).…”

Section: Open Eld Testmentioning

confidence: 99%

Effects of sesame oil on learning and memory impairment and biomarkers of oxidative stress in rats with a long-term high-fat diet consumption

Rustaei

Sadeghian

Salehi

et al. 2021

Preprint

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Nowadays, high-fat foods are eaten in most societies, which causes memory impairment and anxiety through the oxidative stress pathway. Sesame oil (SO) has potential antioxidant properties. Therefore, the effects of sesame oil on memory impairment and anxiety caused by a high-fat diet (HFD) in male rats were investigated. Eighty male Wistar rats were divided into eight groups (n = 10): control (standard diet; SD), the HFD, SD + SO (0.5, 1, or 2 ml/kg; once/day, gavage), and HFD + SO (0.5, 1, or 2 ml/kg; once/day, gavage) groups. All diets were given to the animals for three months. Finally, behavioral and oxidative stress parameters were measured. The step-through latency of retention test in SD + SO (0.5 or 1 ml/kg) groups increased more than the control group. Also, the Barnes test on training days revealed that the latency time to find the target hole increased in the HFD group compared with the control group. Moreover, the time spent on the open arms in the SD + SO (0.5 ml/kg) group improved remarkably than the control group. Total oxidant (TOS) level in the HFD + SO (0.5, 1, and 2 ml/kg) groups was lower than the HFD group. The level of total antioxidant capacity (TAC) in the SD + SO (2 ml/kg) group was higher than the SD + SO (0.5 ml/kg) group and the amount of thiol in the HFD group decreased compared with the control group. These findings suggest that the positive effects of SO on memory and anxiety are probably due to its antioxidant properties and the elimination of free radicals.

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The role of 5-HT1A receptors of hippocampal CA1 region in anticonvulsant effects of low-frequency stimulation in amygdala kindled rats

Cited by 12 publications

References 47 publications

Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy

Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy

The effect of sodium channels on neurological/neuronal disorders: A systematic review

Effects of sesame oil on learning and memory impairment and biomarkers of oxidative stress in rats with a long-term high-fat diet consumption

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