The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer

Qiu, Chongyang; Yang, Lei; Wang, Botao; Cui, Lihua; Li, Caixia; Zhuo, Yong; Zhang, Lanqiu; Zhang, Shukun; Zhang, Qi; Wang, Ximo

doi:10.1016/j.biopha.2019.108952

Cited by 28 publications

(31 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, in vivo studies shown that 2-AG induces immunomodulatory effects in PC environment, leading to the dendritic cell maturation and promoting an immunosuppressive microenvironment via increasing of myeloid-derived suppressor cells. Inhibition of tumor proliferation, as well as immunomodulatory effects of 2-AG, were prevented by CB1 receptor antagonists but not by CB2 receptor antagonists, suggesting the involvement of CB1-mediated mechanisms [102]. The effect of the CBs mediated by CB receptors is not the only mechanism involved in the inhibition of pancreatic tumor cell growth; indeed, studies reported that AM251 and other CBs induce cytotoxic effects via a receptor-independent mechanism in Mia PaCa2 [103].…”

Section: Pancreatic and Thyroid Cancersmentioning

confidence: 93%

The Endocannabinoid System: A Target for Cancer Treatment

Laezza

Pagano

Navarra

et al. 2020

IJMS

108

119

View full text Add to dashboard Cite

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.

show abstract

Section: Pancreatic and Thyroid Cancersmentioning

confidence: 93%

The Endocannabinoid System: A Target for Cancer Treatment

Laezza

Pagano

Navarra

et al. 2020

IJMS

108

119

View full text Add to dashboard Cite

show abstract

“…In vitro, AEA was demonstrated to decrease invasion and metastasis by upregulating a tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) [273] and to induce apoptosis via oxidative stress in COX-2- [274] and TRPV1-dependent manner [275]. 2-AG (20 mg/kg/day) showed similar properties in the rodent model, at the same time suppressing tumor immune-mediated surveillance [276]. Therefore, inhibition of degrading enzymes and thus upregulation of eCBs' levels seems to be a valid strategy.…”

Section: Cancermentioning

confidence: 98%

A Guide to Targeting the Endocannabinoid System in Drug Design

Stasiulewicz

Znajdek

Grudzień

et al. 2020

IJMS

View full text Add to dashboard Cite

The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of physiological processes, including nociception, mood regulation, cognitive functions, neurogenesis and neuroprotection, appetite, lipid metabolism, as well as cell growth and proliferation. Thus, ECS proteins, including cannabinoid receptors and their endogenous ligands’ synthesizing and degrading enzymes, are promising therapeutic targets. Their modulation has been employed in or extensively studied as a treatment of multiple diseases. However, due to a complex nature of ECS and its crosstalk with other biological systems, the development of novel drugs turned out to be a challenging task. In this review, we summarize potential therapeutic applications for ECS-targeting drugs, especially focusing on promising synthetic compounds and preclinical studies. We put emphasis on modulation of specific proteins of ECS in different pathophysiological areas. In addition, we stress possible difficulties and risks and highlight proposed solutions. By presenting this review, we point out information pivotal in the spotlight of ECS-targeting drug design, as well as provide an overview of the current state of knowledge on ECS-related pharmacodynamics and show possible directions for needed research.

show abstract

“…These effects include inhibition of proliferation, cell cycle arrest, apoptosis and autophagy [26,27]. Thus, AEA-and 2-AG-dependent anti-proliferative effects have been demonstrated in colon, breast, prostate and cervical cancer cells [20,28,29]. Many of these studies were also conducted with exogenous cannabinoids such as ∆ 9 -THC, which mimics the effects of endocannabinoids on cannabinoid receptors [19].…”

Section: The Endocannabinoid System and The Tumor Microenvironmentmentioning

confidence: 99%

The Immune Endocannabinoid System of the Tumor Microenvironment

Kienzl

Kargl

Schicho

2020

IJMS

View full text Add to dashboard Cite

Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME. Members of the ECS, an entity that consists of cannabinoid receptors, endocannabinoids and their synthesizing/degrading enzymes, have been associated with both tumor growth and rejection. Immune cells express cannabinoid receptors and produce endocannabinoids, thereby forming an “immune endocannabinoid system”. Although in vitro effects of exogenous cannabinoids on immune cells are well described, the role of the ECS in the TME, and hence in tumor development and immunotherapy, is still elusive. This review/opinion discusses the possibility that the “immune endocannabinoid system” can fundamentally influence tumor progression. The widespread influence of cannabinoids on immune cell functions makes the members of the ECS an interesting target that could support immunotherapy.

show abstract

The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer

Cited by 28 publications

References 27 publications

The Endocannabinoid System: A Target for Cancer Treatment

The Endocannabinoid System: A Target for Cancer Treatment

A Guide to Targeting the Endocannabinoid System in Drug Design

The Immune Endocannabinoid System of the Tumor Microenvironment

Contact Info

Product

Resources

About