The role of 18fluoro-deoxyglucose positron emission tomography/computed tomography in resectable pancreatic cancer

SUVmax after (18)fluoro-deoxyglucose positron emission tomography/computed tomography: A tool to define treatment strategies in pancreatic cancer

“…In a previous study, we showed that 18FDG-PET/CT in the preoperative setting could change the therapeutic planning in about 11% of patients. However, we supported its application in selected patients, considering (i) the cost of this procedure and (ii) its controversial reputation in providing a real advantage for the identification of liver and lymph node metastasis compared to conventional imaging [13,15,25]. In the present study, we aimed to evaluate its impact in providing preoperative survival predictors that could help clinicians in the recurrence risk stratification of patients with resectable PDAC and in the choice of the most appropriate treatment (neoadjuvant treatment versus upfront surgery).…”

“…In those patients with abnormal values of serum bilirubin at the time of diagnosis, CA19.9 level was collected after biliary drainage and jaundice resolution. Preoperative diagnostic work-up and staging procedures as well as criteria for surgical resectability were discussed in details in a previous paper [15]. Briefly, the resectability was based on the following criteria: (1) absence of abutment/encasement of portal vein, superior mesenteric vein, hepatic artery, superior mesenteric artery, celiac trunk; (2) absence of infiltration of peripancreatic organs with the exception of common bile duct and duodenum; (3) absence of distant metastases.…”

“…18FDG-PET/CT as a staging procedure in resectable PDAC supporting that the systematic use of the procedure was not justified [15]. Finally, some Authors showed that maximum standardized uptake value (SUVmax) was associated with survival in resectable pancreatic cancer [14,16,17].…”

ACR Appropriateness Criteria® Staging of Pancreatic Ductal Adenocarcinoma

“…One of the challenges encountered in evaluating the studies is that often distant metastases (liver, peritoneal, lung, bone, nodes) were put together into a single group rather than subgroups by the type of distant metastasis. The results are variable across studies with the detection rate of unexpected distant metastases generally identified in patients as probably resectable based on contrast-enhanced CT or MRI, ranging from 2.5% to 41% [43][44][45][46][47][48]. A recent metaanalysis of FDG-PET/CT imaging (4 studies, 101 patients) showed a pooled sensitivity of 64% and specificity of 81% for metastatic nodal disease, and a sensitivity of 67% and specificity of 96% for liver metastases [49].…”

Ultrassom endoscópico convencional versus ultrassom endoscópico com métodos aprimorados no diagnóstico diferencial de lesões pancreáticas benignas e malignas: revisão sistemática e metanálise

“…A tomografia por emissão de pósitrons (PET-CT) com 18F-fluordesoxiglicose apresenta bons resultados no diagnóstico, estadiamento e acompanhamento da resposta ao tratamento do câncer de pâncreas (Crippa et al, 2014;Zhang et al, 2016).…”