The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms

Lang, Brian Hung‐Hin; Law, Tsz Ting

doi:10.1634/theoncologist.2010-0256

Cited by 17 publications

(19 citation statements)

References 53 publications

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“…x Nuclear-medicine studies show that 18 F-FDG-positive-DTC patients have a worse prognosis [36,37]. In our study, only 63 RR patients underwent 18 F-FDG PET/CT.…”

Section: Discussionmentioning

confidence: 64%

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

et al. 2015

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Background. Outcomes vary among patients with radioiodine refractory (RR) differentiated thyroid cancer (DTC). The prognostic factors for survival are not well-known, resulting in difficulty in selectingpatients for newtargetedtherapies.We assessed overall survival (OS) and cancer-specific survival (CSS) from RR-DTC to identify prognostic factors associated with survival. Patients and Methods. The data on all cases of metastatic RR-DTC treated in our center from 1990 to 2011 were retrospectively reviewed. Survival was estimated using the Kaplan-Meier method; associated prognostic factors were assessed using Cox's model. Results. Of 153 cases of metastatic DTC, 59% (n 5 91) met a criterion for RR: that is, 60% (n 5 55) had at least 1 metastasis without

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“…x Nuclear-medicine studies show that 18 F-FDG-positive-DTC patients have a worse prognosis [36,37]. In our study, only 63 RR patients underwent 18 F-FDG PET/CT.…”

Section: Discussionmentioning

confidence: 64%

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

et al. 2015

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“…The reasons why RAI avidity might have been a significant prognostic factor are 2-fold. First, non-RAI-avid DM is generally less differentiated and so behaves more aggressively 19–21. Second, non-RAI-avid DM are less responsive to RAI therapy 21.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Prognostic Factors Associated with Cancer-specific Survival of Differentiated Thyroid Carcinoma Presenting with Distant Metastasis

et al. 2012

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BackgroundBecause patients with differentiated thyroid carcinoma (DTC) presenting with distant metastasis (DM) have a particularly poor prognosis, examining the prognostic factors in this group is essential. We aimed to evaluate the prognostic factors affecting cancer-specific survival (CSS) in DTC patients presenting with DM.MethodsOf the 1227 DTC patients, 51 (4.2 %) presented with DM at diagnosis. All patients underwent a total thyroidectomy, followed by radioiodine (RAI) ablation and postablation whole body scan (WBS). Patients were considered to have an osseous metastasis if one of the metastatic sites involved a bone, while RAI avidity was determined by any visual uptake in a known metastatic site on the first WBS. Factors predictive of CSS were determined by univariate and multivariate analyses by the Cox proportional hazard model.ResultsIn univariate analysis, older age (relative risk [RR] 1.050, 95 % confidence interval [CI] 1.010–1.091, P = 0.014), DM discovered before WBS (RR 3.401, 95 % CI 1.127–10.309, P = 0.030), follicular thyroid carcinoma (RR 3.095, 95 % CI 1.168–8.205, P = 0.025), osseous metastasis (RR 4.695, 95 % CI 1.379–15.873, P = 0.013), non-RAI avidity (RR 3.355, 95 % CI 1.280–8.772, P = 0.014), and external beam radiotherapy to DM (RR 3.241, 95 % CI 1.093–9.614, P = 0.034) were significant poor prognostic factors for CSS. In the multivariate analysis, after adjusting for other factors, osseous metastasis (RR 6.849, 95 % CI 1.495–31.250, P = 0.013) and non-RAI avidity (RR 7.752, 95 % CI 2.198–27.027, P = 0.001) were the two independent poor prognostic factors for CSS. Older age almost reached statistically significance (RR 1.055, 95 % CI 0.996–1.117, P = 0.068).ConclusionsDTC patients presenting with DM accounted for 4.2 % of all patients. Because osseous metastasis and RAI avidity were independent prognostic factors, future therapy should be directed at improving the treatment efficacy of osseous and/or non-RAI-avid metastases.

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“…Lymph node metastases are usually diagnosed by pre-operative USG of the regional neck lymph nodes. [30,31] Jeong et al compared the diagnostic accuracy of 18 F-FDG PET/CT to that of USG for the pre-operative evaluation of CLN status in patients with papillary thyroid cancer. The study concluded that FDG-PET/CT did not provide additional benefits over USG for lateral neck lymph node metastases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of focal thyroid lesions incidentally detected in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography images

Yaylalı

Yüksel

et al. 2014

Indian J Cancer

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Background and Purpose: Increased uptake in the thyroid gland (TG) is often identified as an incidental finding on the whole body fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in non-thyroid cancer patients. Currently, there is no consensus on the appropriate approach for the management of these cases. Thyroid ultrasound, scintigraphy and fine-needle aspiration biopsy (FNAB) are suggested to exclude malignant thyroid lesions. Our aim is to determine the importance of increased F-18-FDG uptake in the TG on positron emission tomography/computed tomography (PET/CT) scans in patients who are being screened for various forms of non-thyroid cancer. Materials and Methods: We evaluated 2000 cases undergoing whole body PET/CT scanning between April 2011 and October 2012. The age, sex, type of primary cancer, maximum standardized uptake value (SUV max ), size of the thyroid nodules and cervical lymph nodes (CLNs) on 18 F-FDG PET/CT images and if available, the biopsy results were evaluated. Results: In total, 57 patients (23 men, 34 women, mean age ± standard deviation (SD), 60.89 ± 14 years) showed an increased fluorine-18-fluorodeoxyglucose ( 18 F-FDG) uptake by the TG (average SUV max : 4.07 ± 3.7). The CLNs were detected in 19/57 patients (33%). Only 20 cases (35%) received FNAB. The final histopathological diagnosis was papillary thyroid carcinoma in seven patients (mean SUV max ± SD: 6.0 ± 5.43) and benign thyroid disease in seven patients (mean SUV max ± SD: 2.36 ± 0.63). The FNAB results were undetermined for six patients. Conclusion: Focal high 18 F-FDG uptake in the TG may be associated with an increased risk of malignancy, but the clinical significance is unclear. More data are needed to elucidate the role of the SUV in the differentiation of benign and malign thyroid lesions. If a focal increase in 18 F-FDG uptake in the TG on PET/CT is present, a prompt histopathological evaluation should be suggested to clinicians for definitive diagnosis.

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The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms

Cited by 17 publications

References 53 publications

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

Evaluating the Prognostic Factors Associated with Cancer-specific Survival of Differentiated Thyroid Carcinoma Presenting with Distant Metastasis

Evaluation of focal thyroid lesions incidentally detected in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography images

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