The Role Oe Mast Cells in Treatment Oe Scabies

Amer, Mohammed; Mostafa, Fawzia Farag; Nasr, Awatif Nagib; El-Harras, M

doi:10.1111/j.1365-4362.1995.tb01564.x

Cited by 19 publications

(14 citation statements)

References 9 publications

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“…Both have been observed in skin biopsies from scabies patients, but again the role of both cells in scabies immunopathogenesis is currently unknown [16,17]. Both have been observed in skin biopsies from scabies patients, but again the role of both cells in scabies immunopathogenesis is currently unknown [16,17].…”

Section: Key Pointsmentioning

confidence: 99%

Immunology of scabies and translational outcomes

Walton

Oprescu

2013

Current Opinion in Infectious Diseases

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Detailing the skin immunopathogenesis in relation to scabies, including the role of macrophages, mast cells and eosinophils, as well as the immunomodulatory effects of parasite evasion mechanisms are essential for the rational design of future therapeutic, diagnostic and preventative tools. Resolving this knowledge gap could ultimately lead to significant improvements in clinical and public health interventions. This article proposes a conceptual model for capacity building to inform future research activities in the field.

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Section: Key Pointsmentioning

confidence: 99%

Immunology of scabies and translational outcomes

Walton

Oprescu

2013

Current Opinion in Infectious Diseases

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“…On the other hand, IL-4 play important rols as chemotactic immune response in skin lesion. Many other histological studies use human and animal models had been detected mast cells and basophils in skin lesion of human and animals infected with scabies (Amer et al ., 1995;Ito et al,2011;Nimmervoll et a l., 2013;Mounsey et al,2015 ). Activated mast cells and basophils rapidly produce some cytokines acadj@garmian.edu.krd Vol.5, No.2 (June, 2018) (including Th2 cytokines IL-4) which are the main molecules as well as that the cytotoxicity against keratinocytes mostly release cytokines responsible for amplify the allergic Th2-type inflammatory response (Bhat et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of some interleukins and immunomodulatory factors in Iraqi scabies patients

Al-Musawi

Al-Bayati

Hussain

2018

Journal of Garmian University

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Scabies is a contagious skin infection, caused by Sarcoptesscabiei. It is one of a neglected parasitic disease. It causes complications that lead to inflammatory and allergic immune response.This study was designed to obtain the role of some cytokines in scabies patients and compare their levels with dermal diseases patients and control (healthy). The study included one hundred and three patients infected with scabies, seven dermal disease patients (positive controls) as well as 34 healthy individual as control group. The blood samples were collected from scabies and dermal disease patients as well as the control groups.Enzyme linked immunosorbent assay(ELISA) was used to measure Interleukine-4 (IL-4), Interleukin-8 (IL-8), Interleukin-17A (IL-17A), Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), Monocyte Chemotactic Protein-1 (MCP-1) and Macrophage Inflammatory Protein-1-α (MIP-1-α) in the serum of scabies patients, dermal disease patients and healthy individuals. The results showed that IL-4, IL-8, IL-17A and TNF-α was higher in scabies patients than in other groups (positive control and healthy), with no significant differences. While both of MIP-α and MCP-1 were higher in scabies patients compared with healthy group, with significant differences. MIP-α was higher in dermal patients individuals than in scabies patients. TNF-α was lower in scabies patients than in healthy group but higher than in dermal disease patient group.There was positive correlation between IL-17A and each of IL-8, TNF-α, MCP-1 and between IL-8 and both of IL-17A and MCP-1, while there was negative correlation between MIP-1-α and both of IL-4 and MCP-1.The results suggested that the scabies infection may induce the systemic and inflammatory immune response.

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“…Moreover, some cases of mastocytosis have presented with massive eosinophilic infiltrates (7). Amer et al described a close relationship between the mediators of inflammation released when mast cells degranulation and clinical and histopathologic findings of scabies were carried out (8). To our knowledge, this is the first case reported of scabies with presentation masquerading as solitary mastocytoma.…”

Section: Discussionmentioning

confidence: 99%

Scabies Presenting as Solitary Mastocytoma‐Like Eruption in An Infant

Salces

Alfaro

Santamaría

et al. 2009

Pediatric Dermatology

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We report a case in which the initial clinical finding was a solitary cutaneous nodule on the wrist of a young infant which urticated when rubbed, and was diagnosed as a solitary mastocytoma. Two months later, she had the onset of a new vesiculo-pustular eruption on the palms and soles, consistent with scabies infestation and treatment with topical permethrin 5% cream resulted in resolution of the entire eruption, including the primary nodule. While scabies has been reported to mimick a variety of conditions including urticaria pigmentosa, to our knowledge no previous cases masquerading as solitary mastocytoma have been reported.

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The Role Oe Mast Cells in Treatment Oe Scabies

Abstract: The number of mast cells are increased in scabietic lesions. This plays a role in the pathogenesis of the clinical and histologic picture of scabies. We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies.

Cited by 19 publications

References 9 publications

Immunology of scabies and translational outcomes

Immunology of scabies and translational outcomes

Evaluation of some interleukins and immunomodulatory factors in Iraqi scabies patients

Scabies Presenting as Solitary Mastocytoma‐Like Eruption in An Infant

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