The role and research progress of PI3K/AKT signaling pathway in non-traumatic osteonecrosis of the femoral head

Wang, Fengming; Wang, Yanan; Wang, Zhenyu; Song, Frank M.

doi:10.53388/tmrth202306012

Cited by 1 publication

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“…Therefore, the key link in the prevention and treatment of SONFH is the mineralization of osteoblasts, which plays an important role in promoting osteogenesis and preventing osteonecrosis [8]. The occurrence and development of SONFH is closely related to the abnormal expression of PI3K/AKT signaling pathway [17]. PI3K and AKT, as the key regulators of this process, play an important regulatory role in the formation and differentiation of osteocytes.…”

Section: Pi3k/akt Signaling Pathway and Sonfhmentioning

confidence: 99%

Research Progress of Traditional Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/Akt Signaling Pathway

2023

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Steroid-induced osteonecrosis of the femoral head (SONFH) is a common bone and joint disease, mainly due to long-term or high-dose use of glucocorticoids leading to femoral head blood supply disorders and bone tissue necrosis. At present, the most effective treatment for SONFH is hip replacement, but there are some limitations and complications. As a traditional medical system, traditional Chinese medicine has the characteristics of multitarget, multi-channel and multi-component, which may provide a new treatment strategy for SONFH. In recent years, more and more studies have shown that traditional Chinese medicine can act on the PI3K/Akt signaling pathway, affect the angiogenesis, osteogenic differentiation, apoptosis and other processes in the necrotic area of the femoral head, thereby promoting angiogenesis and bone repair, and achieving the purpose of protecting the femoral head. This article reviews the research results of traditional Chinese medicine in the treatment of SONFH based on PI3K/Akt signaling pathway, and further provides a reference for the clinical application of traditional Chinese medicine in the treatment of SONFH.

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Section: Pi3k/akt Signaling Pathway and Sonfhmentioning

confidence: 99%

Research Progress of Traditional Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/Akt Signaling Pathway

2023

medsc

View full text Add to dashboard Cite

show abstract

The role and research progress of PI3K/AKT signaling pathway in non-traumatic osteonecrosis of the femoral head

Cited by 1 publication

References 0 publications

Research Progress of Traditional Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/Akt Signaling Pathway

Research Progress of Traditional Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/Akt Signaling Pathway

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