The role and regulatory mechanism of m6A methylation in the nervous system

Jiang, Lingling; Li, Xiaoheng; Wang, Shasha; Yuan, Zengqiang; Cheng, Jinbo

doi:10.3389/fgene.2022.962774

Cited by 6 publications

(9 citation statements)

References 140 publications

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“…About one-third of mRNAs are modified by m6A, regulate the occurrence, development and clinical prognosis of multiple cancers 25 , 26 . The disturbance of m6A levels has been reported to play a vital role in cancer progression and chemotherapy 27 . Nie et al have demonstrated that ALKBH5-HOXA10 loop contributes to cisplatin resistance of epithelial ovarian cancer in JAK2 m6A demethylation-dependent manner 28 .…”

Section: Discussionmentioning

confidence: 99%

PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer

Liu,

Li,

et al. 2023

J. Cancer

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Cervical cancer (CC) is one of the leading cancers among the female reproductive system. The piwi-interacting RNA (piRNA) function and biogenesis has been studied in various cancers, including CC. But the precise mechanism of piRNA in CC is still unknown. In our study, we found that piRNA-17458 was overexpressed in CC tissues and cells. piRNA-17458 mimic and inhibitor promoted and suppressed proliferation, migration and invasion ability of CC cells, respectively. We also demonstrated that piRNA-17458 mimic could contribute to tumor growth in mice xenograft models. Besides, we also found that the piRNA-17458 mimic could enhance mRNA N6-methyladenosine(m6A) levels and increase WTAP stability in CC cells, while the effects of the mimic was reversed by the WTAP knockdown. The results of dual luciferase reporter assay showed that WTAP was a direct target of piRNA-17458. Knockdown of WTAP attenuated proliferation, migration and invasion of CC cells in piRNA-17458 mimic group. Our finding not only demonstrates for the first time that piRNA-17458 is overexpressed in CC tissues and cells, but also shows that piRNA-17458 promotes tumorigenesis of CC in a WTAP-mediated m6A methylation manner.

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Section: Discussionmentioning

confidence: 99%

PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer

Liu,

Li,

et al. 2023

J. Cancer

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“…One of the most common modifications is m6A. There is a growing body of research involving RNA methylation and disease, covering tumors (Su et al, 2019), neurological disorders (Jiang et al, 2022), obesity (Li et al, 2020), and immune response (Wang et al, 2020), but the relationship with IBD needs further investigation. Elevated levels of NLRP3 inflammasome and pro-inflammatory cytokines are the main pathological mechanisms of IBD (Zhen and Zhang, 2019).…”

Section: Discussionmentioning

confidence: 99%

New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

Liang

Wang

et al. 2022

Front. Microbiol.

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The global incidence of inflammatory bowel disease (IBD) has increased rapidly in recent years, but its exact etiology remains unclear. In the past decade, IBD has been reported to be associated with dysbiosis of gut microbiota. Although not yet proven to be a cause or consequence of IBD, the common hypothesis is that at least some alterations in the microbiome are protective or pathogenic. Furthermore, intestinal epithelial cells (IECs) serve as a protective physical barrier for gut microbiota, essential for maintaining intestinal homeostasis and actively contributes to the mucosal immune system. Thus, dysregulation within the intestinal epithelium increases intestinal permeability, promotes the entry of bacteria, toxins, and macromolecules, and disrupts intestinal immune homeostasis, all of which are associated with the clinical course of IBD. This article presents a selective overview of recent studies on bacterial mechanisms that may be protective or promotive of IBD in biological models. Moreover, we summarize and discuss the recent discovery of key modulators and signaling pathways in the IECs that could serve as potential IBD therapeutic targets. Understanding the role of the IECs in the pathogenesis of IBD may help improve the understanding of the inflammatory process and the identification of potential therapeutic targets to help ameliorate this increasingly common disease.

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“…m 6 A is the most abundant mRNA modification and plays an important role in RNA stability, mRNA translation, alternative splicing, and subcellular RNA localization [ 85, 86 ]. m 6 A modifications are regulated by complexes of proteins termed “writers”, “erasers”, and “readers.” which have been recently reviewed ( Fig.…”

Section: Epitranscriptomicsmentioning

confidence: 99%

“…modifications in PDThe importance of RNA modifications, especially m 6 A, in the development and normal function of the nervous system is well-established and dysregulation of these modifications has been implicated in multiple neurological diseases and aging[85,86,[103][104][105][106][107]. Studies of m 6 A in PD models and the human brain have only recently begun to be performed, and more research is needed to develop a comprehensive understanding of m 6 A activity in relation to PD-associated neurodegeneration.…”

mentioning

confidence: 99%

Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

Gionco,

Bernstein

2024

JPD

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Environmental risk factors and gene-environment interactions play a critical role in Parkinson’s disease (PD). However, the relatively large contribution of environmental risk factors in the overwhelming majority of PD cases has been widely neglected in the field. A “PD prevention agenda” proposed in this journal laid out a set of research priorities focused on preventing PD through modification of environmental risk factors. This agenda includes a call for preclinical studies to employ new high-throughput methods for analyzing transcriptomics and epigenomics to provide a deeper understanding of the effects of exposures linked to PD. Here, we focus on epitranscriptomics as a novel area of research with the potential to add to our understanding of the interplay between genes and environmental exposures in PD. Both epigenetics and epitranscriptomics have been recognized as potential mediators of the complex relationship between genes, environment, and disease. Multiple studies have identified epigenetic alterations, such as DNA methylation, associated with PD and PD-related exposures in human studies and preclinical models. In addition, recent technological advancements have made it possible to study epitranscriptomic RNA modifications, such as RNA N6-methyladenosine (m6A), and a handful of recent studies have begun to explore epitranscriptomics in PD-relevant exposure models. Continued exploration of epitranscriptomic mechanisms in environmentally relevant PD models offers the opportunity to identify biomarkers, pre-degenerative changes that precede symptom onset, and potential mitigation strategies for disease prevention and treatment.

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The role and regulatory mechanism of m6A methylation in the nervous system

Cited by 6 publications

References 140 publications

PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer

PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer

New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

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