The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

Topo, Enza; Soricelli, Andrea; D’Aniello, Antimo; Ronsini, Salvatore; D’Aniello, Gemma

doi:10.1186/1477-7827-7-120

Cited by 100 publications

(125 citation statements)

References 29 publications

(44 reference statements)

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“…The study concluded that DAA is involved in steroidogenesis. Additional studies using rodents have found similar results [100,49].…”

Section: Non-herbal Dietary Supplementssupporting

confidence: 69%

“…The study concluded that DAA is involved in steroidogenesis. Additional studies using rodents have found similar results [100,49].Studies of DAA involving human subjects are scarce. In the first published study, Topo and colleagues found that testosterone levels were significantly elevated in response to DAA supplementation [49].…”

supporting

confidence: 58%

“…One important note from this study was the average age of the subjects (22.8 ± 4.67), which may have had an influence on the overall change in testosterone levels. That is, younger men in this study presented with moderate levels of testosterone and this may have dampened the ability of DAA to yield an increase, in particular as compared to those subjects tested in the study of Topo and colleagues [49]. It is possible that a higher dosage of DAA may be necessary to bring about an increase in testosterone.…”

mentioning

confidence: 70%

Section: Non-herbal Dietary Supplementsmentioning

confidence: 99%

“…This amino acid has been studied extensively in animals for its ability to increase testosterone and improve associated outcomes. However, only two published studies to our knowledge have investigated the lone use of DAA in human subjects, with mixed results [49,97].Derived from arginine, DAA was first discovered in 1827 by Plissan in asparagus juice. Two forms of aspartic acid exist in "L-aspartic acid" and "D-aspartic acid" and appear to have different functions.…”

mentioning

confidence: 99%

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Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Low circulating testosterone levels can present numerous problems related to the overall health and well-being of individuals, men in particular. This finding is well-documented in the literature and low testosterone appears more prevalent in older men, in particular those who are physically inactive and who present with elevated levels of body fat. Multiple botanical (herbal) products have been claimed to elevate circulating testosterone in men; however, data pertaining to the use of such herbal preparations obtained from human clinical trials are limited. This review examines the research to date pertaining to the use of herbal ingredients with regards to their ability to elevate blood testosterone levels. A collective summary of the findings indicate that certain herbal supplements may actually yield an increase in testosterone (e.g., Longjack root), while most others have little to no evidence in support of their use in human subjects. Additional, well-controlled clinical trials are needed to generate data relative to the use of herbal dietary supplements to increase circulating testosterone. Testosterone is generally measured as either "free" (unbound) or "total" (unbound and chemically bound). Men who have a morning serum testosterone level < 300 ng/dL are considered to be "low" and may be a candidate for testosterone replacement therapy-which has become more common in recent years due to the increased diagnosis of andropause [55]. Insufficient levels of testosterone due to either impaired production or uptake can present serious health consequences due to the wide array of applications of testosterone within the human body. Areas including skeletal muscle health, muscular strength, and overall well-being/vitality seem to be significantly affected by testosterone status. Increasing Circulating Testosterone: Impact of Herbal Dietary SupplementsTrintThe role of testosterone in muscle growth has been investigated extensively in both humans and animals [56][57][58][59][60][61][62]. One study in men concluded that the testosterone-induced increase in muscle volume is due to muscle fiber hypertrophy [63]. A follow-up study conducted a year later noted muscle hypertrophy in men over a period of 20 weeks of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of testosterone enanthate. The main findings from this study indicated that testosterone administration was associated with a significant increase in myonuclear number in men receiving the 300-and 600-mg doses.Muscular strength is another important factor that has been shown to be affected by testosterone levels in the body [56,61,62,[64][65][66]. A recent investigation utilized 267 men with stages 2-4 of Chronic Kidney Disease to assess the impact of testosterone level on a variety of variables [64]. This study found that testosterone was significantly and independently associated with handgrip strength, muscle mass, and nutritional status as the disease progressed. Another study explored short-term testoste...

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“…The study concluded that DAA is involved in steroidogenesis. Additional studies using rodents have found similar results [100,49].…”

Section: Non-herbal Dietary Supplementssupporting

confidence: 69%

supporting

confidence: 58%

mentioning

confidence: 70%

Section: Non-herbal Dietary Supplementsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Organic Synthesis with Isomerases

2022

Enzyme‐Based Organic Synthesis

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d‐Amino acids in biological systems

Wey

Armstrong

2023

Chirality

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Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino acid‐containing peptides and proteins in living systems have increased in frequency and significance. Their occurrence and roles may vary substantially with progression from microbiotic to evermore advanced macrobiotic systems. We now understand many of the biosynthetic and regulatory pathways, which are outlined herein. Important uses for D‐amino acids in plants, invertebrates, and vertebrates are reviewed. Given its importance, a separate section on the occurrence and role of D‐amino acids in human disease is presented.

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The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

Abstract: D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.

Cited by 100 publications

References 29 publications

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Organic Synthesis with Isomerases

d‐Amino acids in biological systems

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