The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease

Tao, Pengyu; Ji, Jing; Wang, Qian; Cui, Mengmeng; Cao, Mingfeng; Xu, Yuzhen

doi:10.3389/fimmu.2022.1080456

Cited by 16 publications

(13 citation statements)

References 119 publications

(128 reference statements)

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“…Research suggests that the gut microbiota may affect DKD development by modulating endocrine functions and the composition of microbial metabolic byproducts within the gut[ 27 ]. Notably, SCFAs derived from the gut microbiota can regulate inflammation, oxidative stress, fibrosis, and energy metabolism, thus offering preventive and therapeutic potential in DKD[ 6 ]. Experimental evidence indicates a notable decrease in DKD incidence in diabetes-induced animals fed a high-fiber diet, emphasizing the potential renoprotective role of DF.…”

Section: Discussionmentioning

confidence: 99%

“…DKD markedly increases the risk of cardiovascular events and progression to end-stage renal disease[ 4 , 5 ], culminating in the need for dialysis or renal transplantation. Existing therapeutic approaches offer only symptomatic relief and cannot impede the progression of DKD into chronic kidney disease (CKD)[ 6 ]. Therefore, delaying or ameliorating the onset and progression of DKD is crucial.…”

Section: Introductionmentioning

confidence: 99%

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Dietary fiber intake and its association with diabetic kidney disease in American adults with diabetes: A cross-sectional study

Jia,

Wang,

Sun

2024

World J Diabetes

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BACKGROUND Dietary fiber (DF) intake may have a protective effect against type 2 diabetes (T2D); however, its relationship with diabetic kidney disease (DKD) remains unclear. AIM To investigate the potential association between DF intake and the prevalence of DKD in individuals diagnosed with T2D. METHODS This cross-sectional study used data from the National Health and Nutrition Examination Survey collected between 2005 and 2018. DF intake was assessed through 24-h dietary recall interviews, and DKD diagnosis in individuals with T2D was based on predefined criteria, including albuminuria, impaired glomerular filtration rate, or a combination of both. Logistic regression analysis was used to assess the association between DF intake and DKD, and comprehensive subgroup and sensitivity analyses were performed. RESULTS Among the 6032 participants, 38.4% had DKD. With lower DF intake-T1 (≤ 6.4 g/1000 kcal/day)-as a reference, the adjusted odds ratio for DF and DKD for levels T2 (6.5-10.0 g/1000 kcal/day) and T3 (≥ 10.1 g/1000 kcal/day) were 0.97 (95%CI: 0.84-1.12, P = 0.674) and 0.79 (95%CI: 0.68-0.92, P = 0.002), respectively. The subgroup analysis yielded consistent results across various demographic and health-related subgroups, with no statistically significant interactions (all P > 0.05). CONCLUSION In United States adults with T2D, increased DF intake may be related to reduced DKD incidence. Further research is required to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary fiber intake and its association with diabetic kidney disease in American adults with diabetes: A cross-sectional study

Jia,

Wang,

Sun

2024

World J Diabetes

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“…The human gut microbiota consists of approximately 10 14 microorganisms and plays a crucial role in host function, especially in immunity and metabolism ( Tao et al., 2022 ; Niu and Meng, 2023 ). Many studies demonstrated that the gut microbiota is closely interrelated with GBC progression, but most relative mechanistic studies have primarily focused on bacteria.…”

Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.

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“…In fact, numerous studies have shown that gut microbiota dysbiosis can trigger oxidative stress and play a key role in the pathogenesis of DKD (Fang Q. et al, 2021;Mosterd et al, 2021;Ni et al, 2022;Tao et al, 2022). It has been demonstrated that increased circulating levels of typical gut microbiota-derived uremic toxins, including PCS, IS, PS and TMAO, trigger oxidative stress and increase the production of ROS, which activates NLRP3 inflammasome, leading to inflammation in glomerular endothelial cells and exacerbating renal dysfunction of DKD (Chen et al, 2017;Fang Q. et al, 2021;Huang et al, 2017a;Mosterd et al, 2021;Ni et al, 2022).…”

Section: Gut Microbiota Dysbiosis and Oxidative Stress In Dkdmentioning

confidence: 99%

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

Zhao

Zhāng

et al. 2023

Front. Physiol.

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Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates in the progression of DKD, which is involved in insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation with probiotics or prebiotics, fecal microbiota transplantation and diabetic agents that modulate the gut microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize the most important findings about the role of the gut microbiota in the pathogenesis of DKD and the application of gut microbiota-targeted therapies.

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The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease

Cited by 16 publications

References 119 publications

Dietary fiber intake and its association with diabetic kidney disease in American adults with diabetes: A cross-sectional study

Dietary fiber intake and its association with diabetic kidney disease in American adults with diabetes: A cross-sectional study

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

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