The Role and Mechanism of Intestinal Flora in Blood Pressure Regulation and Hypertension Development

Li, Jing; Yang, Xinchun; Zhou, Xin; Cai, Jun

doi:10.1089/ars.2020.8104

Cited by 31 publications

(31 citation statements)

References 155 publications

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“…A number of scholars have supported and characterized “microbiome–gut–brain (MGB) axis” and illuminated a possible role of gut microbiota dysbiosis in a variety of diseases, such as obesity (Torres-Fuentes et al, 2017 ), inflammatory bowel disease (Lahtinen et al, 2020 ), and hypertension (Li et al, 2020 ). Although previous studies have demonstrated that microbial communities may influence our health, further attention needs to be paid to the potential associations between maternal gut microbiome and PPD.…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Zhou

Chen

et al. 2020

Front. Cell. Infect. Microbiol.

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Postpartum depressive disorder (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. However, the pathogenesis of PPD has still remained elusive, and it may associate with genetic and environmental factors. Gut microbiota has already been proved to be associated with depression; however, a limited number of studies have concentrated on PPD. The present study aimed to explore the potential correlations between gut microbiota and PPD. In this study, 57 participants were enrolled, in which fecal samples of 28 patients with PPD and 16 healthy controls (HCs) were collected and then analyzed by high-throughput sequencing of the 16S ribosomal RNA (rRNA) gene. The results showed that diversity and composition of gut microbial communities were partly different between PPD patients and HCs. The relative abundance of Firmicutes phyla was lower in PPD patients. The levels of several predominant genera were significantly different between PPD patients and HCs. More importantly, the PPD patients experienced reduced levels of Faecalibacterium, Phascolarctobacterium, Butyricicoccus , and Lachnospiraceae , as well as increased levels of Enterobacteriaceae family. In addition, a correlation was observed between levels of Phascolarctobacterium, Lachnospiraceae, Faecalibacterium , and Tyzzerella.3 and the severity of depressive symptoms. Various kinds of bacteria, such as Lachnospiraceae and Faecalibacterium , were found to be associated with levels of sex hormones. This study indicated the correlation between gut microbiota and PPD, and gut microbiota-based biomarkers may be helpful for the diagnosis and treatment of PPD patients. However, further studies need to be conducted to clarify the cause–effect relationship between PPD patients and gut microbiota and to highlight the suitability of gut microbiome as a biomarker.

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Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Zhou

Chen

et al. 2020

Front. Cell. Infect. Microbiol.

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“…The differences between the concentration of hexadecanamide in the serum is interesting and suggests that future studies should be carried out to clarify its role in hypertension. While hexadecanamide was only found in one study, an increase in hexadecanoic acid, a fatty acid, was determined in several of the 17 hypertensive studies [ 30 , 34 , 35 ]. Hexadecanoic acid is the most common saturated fatty acid in the human body and a disruption of its ratio in membrane fluidity has been tied to a variety of physiological diseases, such as diabetes, cardiovascular disease, and hypertension [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hexadecenoic acid has a role in the de novo lipogenesis pathway and heart failure, however more research is needed to define its direct role in hypertension [ 38 ]. Similarly, several studies cited an increase in or aberrant changes in stearic acid, a carboxylic acid derivative of stearamide, in hypertension [ 2 , 35 , 39 ]. While stearamide does not have a reported role in essential hypertension, stearic acid is inversely associated with diastolic blood pressure and may be an indication of coronary heart disease risk [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study

et al. 2021

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Recent metabolomics studies have identified a wide array of microbial metabolites and metabolite pathways that are significantly altered in hypertension. However, whether these metabolites play an active role in pathogenesis of hypertension or are altered because of this has yet to be determined. In the current study, we hypothesized that metabolite changes common between hypertension models may unify hypertension’s pathophysiology with respect to metabolites. We utilized two common mouse models of experimental hypertension: L-arginine methyl ester hydrochloride (L-NAME)/high-salt-diet-induced hypertension (LSHTN) and angiotensin II induced hypertension (AHTN). To identify common metabolites that were altered across both models, we performed untargeted global metabolomics analysis in serum and urine and the resulting data were analyzed using MetaboAnalyst software and compared to control mice. A total of 41 serum metabolites were identified as being significantly altered in any hypertensive model compared to the controls. Of these compounds, 14 were commonly changed in both hypertensive groups, with 4 significantly increased and 10 significantly decreased. In the urine, six metabolites were significantly altered in any hypertensive group with respect to the control; however, none of them were common between the hypertensive groups. These findings demonstrate that a modest, but potentially important, number of serum metabolites are commonly altered between experimental hypertension models. Further studies of the newly identified metabolites from this untargeted metabolomics analysis may lead to a greater understanding of the association between gut dysbiosis and hypertension.

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“…With increasing economic development, the increased consumption of energy-dense and processed foods, and reduced consumption of dietary fiber have been considered the leading risk factor for HTN. Furthermore, gut microbial dysbiosis related to HTN pathology was involved in nutrient metabolism, systemic immunity, inflammation, and the bowel function of the gut barrier [ 45 , 46 ].…”

Section: Dietary Intervention In Htnmentioning

confidence: 99%

Influence of Dietary Components and Traditional Chinese Medicine on Hypertension: A Potential Role for Gut Microbiota

Zhang

Jin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Hypertension (HTN) is an important worldwide public health issue affecting human health. The pathogenesis of HTN involves complex factors such as genetics, external environment, diet, and the gut microbial dysbiosis. The gut microbiota, as a medium of diet and drug metabolism, is closely correlated to host’s health and disease (including HTN). Literatures were randomly collected from various databases including PubMed, ScienceDirect, Google Scholar, and China National Knowledge Infrastructure (CNKI). In this review, we elucidate the relationship between HTN and gut microbiota, as well as concerning the effects of different dietary components, diet-derived microbial metabolites, and traditional Chinese medicine (TCM) on intestinal flora. These studies have shown that diet and TCM can regulate and balance the intestinal flora, which are inclined to increasing the abundance of Akkermansia, Bifidobacterium, and Bacteroides and reducing the ratio of Firmicutes and Bacteroidetes. Moreover, monitoring the dynamic change of gut microflora may indicate patient prognosis and personalized response to treatment. This review aims to provide novel perspectives and potential personalized interventions for future HTN management from the perspective of gut microbiota.

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The Role and Mechanism of Intestinal Flora in Blood Pressure Regulation and Hypertension Development

Cited by 31 publications

References 155 publications

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study

Influence of Dietary Components and Traditional Chinese Medicine on Hypertension: A Potential Role for Gut Microbiota

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