Abstract:Background: Neuroinflammation and oxidative stress are closely related to the pathogenesis of Parkinson's disease (PD), and PD is pathologically characterized by progressive loss of dopaminergic neurons in the SN pars compacta and excessive accumulation of α-synuclein. Endophilin A1(EPA1) is a cytoplasmic protein that is widely expressed in presynaptic nerve terminals in the brain and regulates synaptic vesicle cycling. EPA1 is encoded by the SH3GL2 gene, and SH3GL2 was designated as a PD risk locus by genome-… Show more
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