The role and mechanism of quercetin via TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis
Chenglin Kang,
Jiangqi Liu,
Zhisheng Wu
et al.
Abstract:An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to investigate whether quercetin (QUE) treats AR via TLR4/MyD88/IRAK4 signaling pathway. SPF grade Balb/c mice were randomly divided into 4 groups: normal control (NC), OVA, dexamethasone (DEX), and (QUE) groups. OVA and aluminum hydroxide [AL(OH)3] were injected intraperitoneally for basic sensitization and OVA was dripped into the nose for challenge to induce a mouse model of AR. The mice were scored by observing the behaviors of s… Show more
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