The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats

Korolkiewicz, Roman; Anand, Jacek Sein; Ruczyński, Jarosław; Rekowski, Piotr; Bieniaszewski, Leszek; Chodorowski, Z; Petrusewicz, Jacek; Ujda, Marek; Dabkowski, J.; Bitel, M.; Kato, Shinichi; Takeuchi, Koji

doi:10.1016/j.gassur.2003.11.004

Cited by 16 publications

(3 citation statements)

References 37 publications

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“…Another limitation of direct measurement of Evans blue given via orogastric tube is that it reflects not only the intestinal transit but also the stomach emptying. On the other hand, results obtained in the preparatory phase of this study confirmed previous reports showing reproducibility and correlation of dye migration reduction with the degree of invasiveness of surgical procedures (De Winter et al 1997 ; Korolkiewicz et al 2003 , 2004 ). Therefore, we concluded that the chosen method of measuring the gastrointestinal passage, despite its setbacks, satisfactorily reflects the early phase of postoperative ileus in rats.…”

Section: Discussionsupporting

confidence: 91%

“…During the procedures, standard aseptic procedures were undertaken. Procedures were performed according to slightly modified protocol used by De Winter ( 1997 ) and in previous research in our department (Korolkiewicz et al 2003 , 2004 ).…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the release of proinflammatory cytokines increases expression of adhesion molecules (P-selectin, intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1)) and leads to further leukocyte recruitment and inflammation (Kalff et al 1999 ). Effects of prostaglandins and nitric oxide were also previously researched in our department (Korolkiewicz et al 2003 , 2004 ).…”

Section: Introductionmentioning

confidence: 96%

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The role of beta-adrenoreceptors in postoperative ileus in rats

Marcin,

Katarzyna,

Ivan

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following abdominal surgery in rat model of postoperative ileus. Bowel motility was measured by the intestinal transit of Evans blue introduced via orogastric tube after surgical procedures of skin incision, laparotomy and laparotomy with gut manipulation. Male rats were given individual adrenergic receptor subtypes antagonists intraperitoneally, and the influence of administered agents on intestinal transit of Evans blue was then evaluated. No statistically significant differences in the length of intestine in tested rats were observed. Propranolol administered prior to surgical procedure has shown protective effect on Evans blue migration in rats undergoing laparotomy and gut manipulation. Intestinal dye transit for propranolol doses of 10, 30 and 45 mg/kg was 18.00 ± 1.88c m, 23.75 ± 1.71 cm and 22.5 ± 2.43 cm, respectively, and for last two doses, statistically significant increase of dye passage was noted, compared to Evans blue transit of 11.00 ± 2.43 cm in the control group. No acceleration of dye migration was seen following administration of beta1-, beta2- and beta3-selective adrenergic receptor antagonist metoprolol, ICI 118.551 and SR58894A, respectively. Our research confirmed that propranolol at high doses, as seen by other researchers, improved bowel motility in early phase of postoperative ileus. That slight acceleration of intestinal dye transit after surgery with gut manipulation is rather connected with membrane-stabilizing action, than the receptor blocking effect, as this effect was not observed after the application of selective antagonists of respective subtypes of beta-adrenergic receptor.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%