The role and importance of fungal infections in intensive care units, ICU

Tatic, R Milanka; Stanic-Canji, Danica; Draskovic, G Biljana; Komarcevic, Aleksandar; Gajdobranski, R Djordje

doi:10.2298/mpns0312537t

Cited by 4 publications

(1 citation statement)

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“…C. albicans (CA) is well known as an opportunistic fungus existing in normal organisms, but could cause superficial and systemic infections in immunocompromised or debilitated hosts such as patients with cancer and AIDS. Though superficial CA infections are nonlethal, systemic candidiasis infections result in high modality and mortality in mildly immunocompromised individuals even with antifungal therapy . During the past decades, therapeutic antifungals have been widely used against candidiasis, dramatically increasing the drug tolerance and resistance .…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

Huai

Dong

Zhu

et al. 2016

Adv Healthcare Materials

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Candida albicans (CA) is a kind of fungi that can cause high morbidity and mortality in immunocompromised patients. However, preventing CA infection in these patients is still a daunting challenge. Herein, inspired from the fact that immunization with Secreted aspartyl proteinases 2 (Sap2) could prevent the infection, we propose to use filamentous phage, a human-safe virus nanofiber specifically infecting bacteria (~900 nm long and 7 nm wide), to display an epitope peptide of Sap2 (EPS, with a sequence of Val-Lys-Tyr-Thr-Ser) on its side wall and thus serve as a vaccine for preventing CA infection. The engineered virus nanofibers and recombinant Sap2 (rSap2) are then separately used to immunize mice. The humoral and cellular immune responses in the immunized mice are evaluated. Surprisingly, the virus nanofibers significantly induce mice to produce strong immune response as rSap2 and generate antibodies that can bind Sap2 and CA to inhibit the CA infection. Consequently, immunization with the virus nanofibers in mice dramatically increase the survival rate of CA-infected mice. All these results, along with the fact that the virus nanofibers can be mass-produced by infecting bacteria cost-effectively, suggest that virus nanofibers displaying EPS can be a vaccine candidate against fungal infection.

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Section: Introductionmentioning

confidence: 99%

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

Huai

Dong

Zhu

et al. 2016

Adv Healthcare Materials

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Candidiasis peritoneal: prevalencia y factores de riesgo

Hernández

Balaguer

Armero

et al. 2013

Revista Iberoamericana de Micología

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Infections associated with the central venous catheters

et al. 2014

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Central venous catheters are of an essential importance to critically ill patients who require long-term venous access for various purposes. Their use made the treatment much easier, but still they are not harmless and are prone to numerous complications. Catheter infections represent the most significant complication in their use. The frequency of infections varies in different patient care settings, but their appearance mostly depends on the patient's health condition, catheter insertion time, localization of the catheter and type of the used catheter. Since they are one of the leading causes of nosocomial infections and related to significant number of morbidity and mortality in intensive care units, it is very important that maximal aseptic precautions are taken during the insertion and the maintenance period. Prevention of infection of the central venous catheters demands several measures that should be applied routinely.

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The role and importance of fungal infections in intensive care units, ICU

Abstract: Treatment is usually based on systemic antimycotic agents (Amphotericin B, Azoles: Fluconazole, Flucytosine). Prophylactic treatment is still a matter of debate. It is not routinely recommended in ICU, but is commonly used in transplant patients.

Cited by 4 publications

References 1 publication

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection

Candidiasis peritoneal: prevalencia y factores de riesgo

Infections associated with the central venous catheters

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