A popular practice is the application of friction modifiers to increase the adhesion level between wheel and rail under different contamination conditions.Particularly, two friction modifiers have been used or tested in several railway networks as adhesion enhancers to facilitate the traction and braking operation under poor adhesion conditions. However, the railway operators and infrastructure managers only count with practical observations that do not elucidate completely the effectiveness and side effects of these adhesion enhancers. In this paper, a twin-disk roller rig has been used to study their performance in dry and wet contacts under closely controlled laboratory conditions. The adhesion characteristics of both friction modifiers are examined for different slip ratios. The constituents of the friction modifiers are identified and the solid components are analyzed. Furthermore, the wheel and rail disks are examined after a series of dry tests to analyze the mass loss, surface damage, modification of surface hardness and roughness, and subsurface deformation caused by the friction modifiers compared to dry contacts.