The role and clinical effectiveness of multimodality imaging in the management of cardiac complications of cancer and cancer therapy

Russell, Raymond R.; Alexander, Jonathan; Jain, Diwakar; Poornima, Indu; Srivastava, Ajay; Storozynsky, Eugene; Schwartz, Ronald G.

doi:10.1007/s12350-016-0538-8

Cited by 52 publications

(33 citation statements)

References 161 publications

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“…Though, when compared to planar image acquisition, SPECT ERNA acquired with high-sensitivity CZT cameras can be done with lower radiation dose, faster image acquisition time, and improved reproducibility. 4,8,11,15 Several studies have been published indicating that tomographic MUGA as a potential replacement for the planar MUGA. 4,5,16,17 In addition, there may be a tendency to decrease the number of ERNA.…”

Section: 65mentioning

confidence: 99%

Equilibrium radionuclide angiography: Present and future

Romero-Farina

Aguadé-Bruix

2021

Journal of Nuclear Cardiology

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This editorial refers to the article published by Sachpekidis et al 1 titled 'Equilibrium radionuclide angiography (ERNA): intra-and interobserver repeatability and reproducibility in the assessment of cardiac systolic and diastolic function' on the Journal of Nuclear Cardiology. The objective of this study was to assess the intra-and interobserver agreement in assessing the systolic and diastolic function with ERNA. The authors analyzed thirty-two adults underwent baseline and repeat ERNA. An experienced and a trainee operator analyzed the data by assigning regions of interest manually, fully automatically, and semi-automatically. The Bland-Altman statistic was used to assess the repeatability (two different assessments of a single acquisition) and reproducibility (assessments of two different acquisitions). According to the obtained results, the Authors concluded that: 'A good repeatability but a moderate reproducibility was found in the assessment of the left ventricular ejection fraction (LVEF). Less good were the findings in the assessment of diastolic function. The results also depended on the software tool'.This article provides interesting information about the intra-and interobserver repeatability and reproducibility in the assessment of cardiac systolic and diastolic function. Despite the fact that in the conclusions of this study the authors say that ERNA has a moderate reproducibility in the assessment of the LVEF; ERNA continues to be one of the best imaging techniques for the analysis of ventricular function. The analysis of the variability in the measurements of a technique is complex and not only depends on of the intra-and interobserver variability, but of other variabilities that are not generally taken into account, such as the day-to-day variability of the phenomenon studied, the variability of the pathology, age, gender, etc. In addition to this research study, it has a very heterogeneous population (men = 20, women = 12, heart failure = 13, cardiotoxic chemotherapy = 12, different degree of systolic dysfunction) in a small (n = 31) number of patients. Table 1 shows the reproducibility, and inter-and intra-observer variations of ERNA according to different acquisition methodology to evaluate left and right ventricular function. 1-7 ERNA has a high reproducibility, very low inter-or intra-observer variability, and high precision; it has been shown to be accurate when compared to other modalities and has strong early data that demonstrated efficacy in guiding the safety of treatment regimens, and it continues to be widely used for routine clinical monitoring. 8 This information is consistent with the comments of Sachpekidis et al. 9 in a previous review. Haarmark et al 10 evaluated 463 subjects without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease, by means of Cadmium Zinc Telluride (CZT) SPECT camera. They conclude that there are age-related changes in cardiac dimensions with age depending on gender, although with only

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Section: 65mentioning

confidence: 99%

Equilibrium radionuclide angiography: Present and future

Romero-Farina

Aguadé-Bruix

2021

Journal of Nuclear Cardiology

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“…The dose related to radiation treatments is measured in grey (Gy) units, which is the absorption of 1 J of ionizing radiation energy by 1 kg of tissue. Even minimal doses have been associated with long-term cardiovascular consequences, which is important in view of the improving radiation techniques over time with overall lower exposures [13,15].…”

Section: Pre-treatment Risk Stratificationmentioning

confidence: 99%

Applications of Cardiac Computed Tomography in the Cardio-Oncology Population

Layoun

Yang

Herrmann

et al. 2019

Curr. Treat. Options in Oncol.

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Opinion statementThe increased risk for cardiovascular events in aging cancer survivors and those undergoing certain chemotherapeutic treatments has raised concern for more rigorous screening and surveillance methods above that of the general population. At this time, there are limited guidelines for how to best manage this vulnerable cohort. Questions regarding timing of screening, choice of imaging modality and risk reduction strategies-especially in those patients with known atherosclerotic disease-remain to be elucidated. Over a decade of case series, retrospective studies and clinical trials have shed light on the evolving role of cardiac computed tomography (CT) in this population, of which there is a relative paucity of data regarding its potential utility in the specific cardio-oncology population. Focusing on ability of cardiac CT to evaluate multiple cardiac and vascular structures, provide diagnostic and prognostic information, as well as assist interventional and surgical colleagues in surgical/percutaneous valve replacement and revascularization strategies is the premise for this review.

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“…61e63 Similar recommendations regarding baseline assessment of LVEF are mirrored by a joint statement by the American Society of Nuclear Cardiology (ASNC), the European Society of Cardiology (ESC), and the American Society of Echocardiography (ASE) with the European Association of Cardiovascular Imaging (EACVI). 1,64,65 Baseline assessment would allow clinicians to differentiate whether a subsequent decline in LVEF is due to cancer therapy versus preexisting LV dysfunction.…”

Section: Prechemotherapy Surveillancementioning

confidence: 99%

“…CAN and ASNC prefer MUGA over echocardiogram for routine surveillance because of its increased sensitivity in picking up a change in LVEF of 10%. 64,66 Whichever imaging modality is ultimately chosen, all guideline committees agree that using the same imaging modality, machine, operator, and calculation algorithms for each subsequent study is important 1,62 (Table 10.…”

Section: Surveillance With Biomarkers and Strain Imagingmentioning

confidence: 99%