The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection

Trimpert, Jakob; Vladimirova, Daria; Dietert, Kristina; Abdelgawad, Azza; Kunec, Dušan; Dökel, Simon; Voß, Anne; Gruber, Achim D.; Bertzbach, Luca D.; Osterrieder, Nikolaus

doi:10.1016/j.celrep.2020.108488

Cited by 86 publications

(126 citation statements)

References 54 publications

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“…Most non-transgenic laboratory mice (Mus musculus) are resistant to infection, while transgenic humanized mice and hamsters, including Syrian hamsters (Mesocricetus auratus) and dwarf hamsters (Phodopus sp. ), are highly susceptible, with at least one report of Roborovky's dwarf hamsters becoming fatally diseased within three days of exposure (11,12,13). Other species, including deer mice (Peromyscus maniculatus), become infected and shed low titers of virus, but the infection is subclinical (14,15).…”

Section: Introductionmentioning

confidence: 99%

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

Porter

et al. 2021

Preprint

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Wild animals have been implicated as the origin of SARS-CoV-2, but it is largely unknown how the virus affects most wildlife species and if wildlife could ultimately serve as a reservoir for maintaining the virus outside the human population. Here we show that several common peridomestic species, including deer mice, bushy-tailed woodrats, and striped skunks, are susceptible to infection and can shed the virus in respiratory secretions. In contrast, we demonstrate that cottontail rabbits, fox squirrels, Wyoming ground squirrels, black-tailed prairie dogs, house mice, and racoons are not susceptible to SARS-CoV-2 infection. Our work expands upon the existing knowledge base of susceptible species and provides evidence that human-wildlife interactions could result in continued transmission of SARS-CoV-2.

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Section: Introductionmentioning

confidence: 99%

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

Porter

et al. 2021

Preprint

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“…Unlike the larger Syrian hamsters that show only limited weight loss upon SARS‐CoV‐2 infection, Roborovski dwarf hamsters exhibit robust clinical features of disease within 3 days of infection. These include a significant drop in temperature and weight loss 5 . The animals also display snuffling, dyspnoea, ruffled fur and decreased activity, reaching humane end point by days 3–5, depending on the dose of virus inoculated.…”

Section: Model Pros Consmentioning

confidence: 99%

“…These include a significant drop in temperature and weight loss. 5 The animals also display snuffling, dyspnoea, ruffled fur and decreased activity, reaching humane end point by days 3-5, depending on the dose of virus inoculated. Viral RNA is abundantly detected in bucco-laryngeal swabs at day 2, whilst the infectious virus is only detectable in blood samples of certain animals.…”

mentioning

confidence: 99%

“…Viral RNA is abundantly detected in bucco-laryngeal swabs at day 2, whilst the infectious virus is only detectable in blood samples of certain animals. 5 Critically, the animals show severe signs of lung damage with alveolar epithelial cell necrosis, haemorrhage and oedema from day 2. Importantly, numerous hyaline thrombi can be observed in inter-alveolar wall capillaries, 5 which is reminiscent of what can be observed in severe COVID-19 patients.…”

mentioning

confidence: 99%

“…5 Critically, the animals show severe signs of lung damage with alveolar epithelial cell necrosis, haemorrhage and oedema from day 2. Importantly, numerous hyaline thrombi can be observed in inter-alveolar wall capillaries, 5 which is reminiscent of what can be observed in severe COVID-19 patients. 6 Similar to K18-hACE2 mice, the lethality of infection in Roborovski dwarf hamsters is independent of brain infection.…”

mentioning

confidence: 99%

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Animal models of COVID‐19 hyper‐inflammation

Gantier

2020

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Characteristics of animal models for COVID‐19

Qin

2022

Anim Models and Exp Med

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of coronavirus disease 2019 (COVID‐19), the most consequential pandemic of this century, threatening human health and public safety. SARS‐CoV‐2 has been continuously evolving through mutation of its genome and variants of concern have emerged. The World Health Organization R&D Blueprint plan convened a range of expert groups to develop animal models for COVID‐19, a core requirement for the prevention and control of SARS‐CoV‐2 pandemic. The animal model construction techniques developed during the SARS‐CoV and MERS‐CoV pandemics were rapidly deployed and applied in the establishment of COVID‐19 animal models. To date, a large number of animal models for COVID‐19, including mice, hamsters, minks and nonhuman primates, have been established. Infectious diseases produce unique manifestations according to the characteristics of the pathogen and modes of infection. Here we classified animal model resources around the infection route of SARS‐CoV‐2, and summarized the characteristics of the animal models constructed via transnasal, localized, and simulated transmission routes of infection.

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The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection

Cited by 86 publications

References 54 publications

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

Animal models of COVID‐19 hyper‐inflammation

Characteristics of animal models for COVID‐19

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