The RNA world of human ageing

Gómez-Verján, Juan Carlos; Vázquez-Martínez, Edgar Ricardo; Rivero-Segura, Nadia Alejandra; Medina-Campos, Raúl Hernán

doi:10.1007/s00439-018-1955-3

Cited by 38 publications

(23 citation statements)

References 122 publications

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“…Due to their lack of protein-coding capacity, ncRNAs have been regarded as transcriptional "noise" for some time. However, a growing number of studies have demonstrated that ncRNAs have critical biological effects on both physiological and pathological processes [17,18], especially in the field of cancer research [19,20].…”

Section: Introductionmentioning

confidence: 99%

The interplay between HIF-1α and noncoding RNAs in cancer

Peng

Han

et al. 2020

J Exp Clin Cancer Res

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Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcriptional regulator in the response to hypoxia, has been demonstrated to significantly modulate hypoxic gene expression and signaling transduction networks. In past few decades, growing numbers of studies have revealed the importance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. These hypoxia-responsive ncRNAs (HRNs) play pivotal roles in regulating hypoxic gene expression at the transcriptional, posttranscriptional, translational and posttranslational levels. In addition, as a significant gene expression regulator, ncRNAs exhibit promising roles in regulating HIF-1α expression at multiple levels. In this review, we briefly elucidate the reciprocal regulation between HIF-1α and ncRNAs, as well as their effect on cancer cell behaviors. We also try to summarize the complex feedback loop existing between these two components. Moreover, we evaluated the biomarker potential of HRNs for the diagnosis and prognosis of cancer, as well as the potential clinical utility of shared regulatory mechanisms between HIF-1α and ncRNAs in cancer treatment, providing novel insights into tumorigenicity, which may lead to innovative clinical applications.

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Section: Introductionmentioning

confidence: 99%

The interplay between HIF-1α and noncoding RNAs in cancer

Peng

Han

et al. 2020

J Exp Clin Cancer Res

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“…Finally which in turn, have been implicated in potentiation of carcinogenesis [36]. Some examples of long non-coding RNAs that have been studied in this context are MALAT1 (metastasis-related lung adenocarcinoma transcript 1), SALNR and HOTAIR (HOX transcript antisense RNA), which are necessary in regulating cellular processes such as promotion of tumor cell proliferation, invasion, metastasis, drug resistance, and angiogenesis, thus playing a key role cancer progression as a result of aging [37].…”

Section: Aging Cancer and Epigeneticsmentioning

confidence: 99%

Epigenetics of aging and disease: a brief overview

et al. 2019

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Aging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function. Epigenetics, which include mechanisms regulating gene expression independently of changes to DNA sequence, regulate gene expression by modulating the structure of chromatin or by regulating the binding of transcriptional machinery to DNA. Several studies showed that an impairment of epigenetic mechanisms promotes alteration of gene expression underlying several aging-related diseases. Alteration of these mechanisms is also linked with changes of gene expression that occurs during aging processes of different tissues. In this review, we will outline the potential role of epigenetics in the onset of two age-related pathologies, cancer and cardiovascular diseases.

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“…Noncoding RNA refers to RNA that does not encode proteins. Among them, those with a length greater than 200 nucleotides are called “long noncoding RNA (lncRNA),” and the length less than 200 nucleotides is called “small noncoding RNA (sncRNA),” such as microRNA (miRNA) [ 16 ]. Unlike sncRNAs, the length of lncRNA allows it to regulate gene expression levels in a more complex transcription and translation network.…”

Section: Introductionmentioning

confidence: 99%

Four Autophagy-Related lncRNAs Predict the Prognosis of HCC through Coexpression and ceRNA Mechanism

Liu

et al. 2020

BioMed Research International

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Abnormally expressed long noncoding RNAs (lncRNAs) have been reported to affect the occurrence and progression of hepatocellular carcinoma (HCC) by modulating the autophagy axis. However, none of studies has explored the clinical significance of these autophagy-related lncRNAs in HCC comprehensively. In this study, the RNA-seq, miRNA-seq, and clinical data of normal and HCC patients from the TCGA database and autophagy genes from the Human Autophagy Database were extracted. Subsequently, we screened out 78 differentially expressed autophagy-related lncRNAs, and four prognostic-related lncRNAs (LUCAT1, AC099850.3, ZFPM2-AS1, and AC009005.1) were eventually used to develop the prognostic model. This signature could be regarded as an independent prognostic signature for HCC patients and has the highest prediction efficiency than other clinicopathological factors for the 1-, 3-, and 5-year survival (AUC=0.764,0.738,and 0.717, respectively). Additionally, regardless of whether the clinical information is complete for HCC patients, the autophagy-related lncRNA model shows a good predictive power for the overall survival. Importantly, the coexpression network of 4 lncRNAs and 11 autophagy-related genes was constructed. Moreover, based on the bioinformatic analyses, our results found that LUCAT1 and ZFPM2-AS1 may affect the autophagic activity in HCC through the hsa-miR-495-3p/DLC1 and hsa-miR-515-5p/DAPK2 axis, respectively. In conclusion, we establish an effective prognostic model for HCC patients and shed new light on the autophagy-related regulatory mechanisms of the identified lncRNAs.

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The RNA world of human ageing

Cited by 38 publications

References 122 publications

The interplay between HIF-1α and noncoding RNAs in cancer

The interplay between HIF-1α and noncoding RNAs in cancer

Epigenetics of aging and disease: a brief overview

Four Autophagy-Related lncRNAs Predict the Prognosis of HCC through Coexpression and ceRNA Mechanism

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