2022
DOI: 10.1101/2022.04.05.487197
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The RNA content of extracellular vesicles fromPRPF31+/−hiPSC-RPE show potential as biomarkers of retinal degeneration

Abstract: Retinitis pigmentosa (RP) is the most common form of inherited retinal degeneration (IRD) and causes vision loss via dysfunction and death of the photoreceptor cells and retinal pigment epithelium (RPE) of the retina. Mutations in pre-mRNA processing factor 31 (PRPF31) are associated with autosomal dominant RP, and are thought to cause retinal degeneration by causing cell autonomous defects in RPE function. Genetic therapies such as adeno-associated virus (AAV) mediated gene therapy show great promise for trea… Show more

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