The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology
Carly L. Lancaster,
Pranav S. Yalamanchili,
Jordan N. Goldy
et al.
Abstract:The Drosophila RNA binding protein (RBP) Nab2 acts in neurons to regulate neurodevelopment and is orthologous to the human intellectual disability-linked RBP, ZC3H14. Nab2 governs axon projection in mushroom body neurons and limits dendritic arborization of class IV sensory neurons in part by regulating splicing events in ∼150 mRNAs. Analysis of the Sex-lethal ( Sxl) mRNA revealed that Nab2 promotes an exon-skipping event and regulates m6A methylation on Sxl pre-mRNA by the Mettl3 methyltransferase. Mettl3 het… Show more
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