The risk of venous thromboembolic disease in patients with monoclonal gammopathy of undetermined significance

Abstract

This study demonstrates that patients with MGUS are at increased risk for VTD. Although a clear reason for the pre-thrombotic state in these patients is not currently evident, few risk factors were identified in the group of patients examined.

Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: incidence and risk factors in a cohort of 1491 patients

“…In three smaller series of 310, 174, and 112 patients with MGUS, the rates of VTE were 6Á1%, 7Á5% and 8%, and the median age of the recruited individuals was 67Á5, 68 and 69Á2 years, respectively (Sallah et al, 2004;Srkalovic et al, 2004;Muslimani et al, 2009). In the population-based 'Study of Men Born in 1913', the prevalence of VTE in a cohort of men followed from the age of 50 years to the age of 80 years was 2% at age 67 (Hansson et al, 1997); therefore, in the …”

“…In one of those studies, multivariate analysis showed a significant association of VTE with age (>65 years), M-protein higher than 16 g/l, and progression to malignancy (Sallah et al, 2004). In contrast, a case-control study carried out in 166 male patients who were hospitalized and had diagnosis of MGUS (median age 71 years) and 465 agematched control patients who had tested negative for the presence of M-protein failed to find a significant difference in the rate of VTE between the two groups (5Á4% and 4Á9% respectively).…”

“…Some studies have investigated whether MGUS, like multiple myeloma, is associated with an increased risk of VTE. Three small studies reported that 6-8% of MGUS patients develop VTE (Sallah et al, 2004;Srkalovic et al, 2004;Muslimani et al, 2009); on the other hand, a case-control study failed to find an association between MGUS and VTE (Cohen & Sarid, 2010). Three population-based registry studies reported a 1Á3-to 3Á4-fold increased risk of VTE in MGUS patients relative to members of the general population (Kristinsson et al, 2008(Kristinsson et al, , 2010Gregersen et al, 2011).…”

“…Recent studies have investigated whether the premalignant condition MGUS is also associated with an increased risk of VTE (Sallah et al, 2004;Srkalovic et al, 2004;Kristinsson et al, 2008Kristinsson et al, , 2010Muslimani et al, 2009;Cohen & Sarid, 2010;Gregersen et al, 2011). We investigated the incidence of a first MGUS-related VTE in a retrospective cohort of 1238 patients with MGUS diagnosed at least 1 year before; the median age at diagnosis was 63 years.…”

Venous Thromboembolism in Cancer Patients

“…In 2004, Sallah S et al and Srkalovic G et al published in Ann Oncol and cancer respectively (201)(202) two small hospital based studies on the association of monoclonal gammopathy of undetermined significance (MGUS) and subsequent risk of DVT and reported an elevated risk of DVT in MGUS. Kristinsson Y et al (203) conducted a retrospective study on 4, 196,197 veterans hospitalized at least once.…”