The risk of secondary cancer in nasopharyngeal carcinoma paediatric patients due to intensity modulated radiotherapy and mega‐voltage cone beam computed tomography

Sherif, Reham S; Attalla, Ehab M.; Elshemey, Wael M.; Madian, Noha G.

doi:10.1111/1754-9485.12562

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…The nomogram was established based on the risk factors of age, race, AJCC, and chemotherapy. Important factors of radiation therapy technique, radiation dose and its distribution were not included due to the limitation of SEER database [19][20][21]. Thus, the nomogram could not provide well-discriminating ability.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of secondary cancer in nasopharyngeal carcinoma patients after radiotherapy

Wang¹,

Li²,

Pan³

2022

J. Cancer

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Purpose: To identify risk factors of secondary cancer in nasopharyngeal carcinoma (NPC) patients after radiotherapy. Materials and methods:The data of NPC patients with secondary cancer were extracted from the Surveillance, Epidemiology, and End Results database from 2004 to 2016. Univariate and multivariate logistic regression analysis was performed to identify risk factors of secondary cancer. Risk factors selected from the multivariable logistic regression analysis were used to build a predicting model. Results: A total of 3931 patients were included: 329 (8.37%) patients developed secondary cancers and 3602 (91.63%) patients did not have secondary cancers. Univariate logistic regression analysis revealed that age, race, and the American Joint Committee on Cancer (AJCC) stage were risk factors of secondary cancer. Multivariable analysis demonstrated that age [Odds ratio (OR) = 1.03, P < 0.001], race (OR = 1.17, P = 0.010), AJCC stage (OR = 0.82, P = 0.002), and chemotherapy (OR = 1.55, P = 0.028) were independent risk factors of secondary cancer. Age, race, AJCC stage, and chemotherapy were entered into a nomogram for predicting secondary cancer. The area under the ROC curve of the nomogram was 0.645 [95% confidence interval (CI): 0.617-0.673]. The decision curve showed that if the threshold probability is between 4% and 25%, using the nomogram added more benefit than either the treat-all-patients scheme or the treat-none scheme. Conclusion: Age, race, AJCC stage, and chemotherapy were independent risk factors of secondary cancer in nasopharyngeal carcinoma patients after radiotherapy.

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Section: Discussionmentioning

confidence: 99%