The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis

Zhu, Feng; Li, Chuling; Gong, Jianfeng; Zhu, Weiming; Gu, Lili

doi:10.1016/j.dld.2018.09.017

Cited by 95 publications

(88 citation statements)

References 20 publications

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“…1.19-1.66), with a 28% and 30% increased risk of PD for CD and UC, respectively [16]. Two studies (American and Swedish) reported an increased hazard ratio in both CD and UC groups [13,15] (table 1).…”

Section: Pd and Ibd Are Epidemiologically Linkedmentioning

confidence: 99%

Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?

et al. 2019

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While the pathogenesis of Parkinson's disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson's disease is however not limited to the brain but also involves the gastrointestinal tract. High amounts of cytokines and inflammatory markers are found in the colon of Parkinson's disease patients and there is now strong epidemiological and genetical evidence linking Parkinson's disease to inflammatory bowel diseases. Recent findings obtained in both experimental inflammatory bowel diseases and Parkinson's disease further support a bidirectional link between gastrointestinal inflammation and brain neurodegeneration. Altogether these observations suggest a role for gastrointestinal inflammation in the initiation and progression of Parkinson's disease.

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Section: Pd and Ibd Are Epidemiologically Linkedmentioning

confidence: 99%

Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?

et al. 2019

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“…All population studies were summarized in an elegant meta-analysis by Zhu et al, demonstrating 46% increased risk of PD in IBD patients compared to controls. The increased risk remained significant when separately analyzing CD and UC groups [70].…”

Section: Epidemiological Evidence For a Link Between Ibd And Pdmentioning

confidence: 93%

Inflammatory Bowel Diseases and Parkinson’s Disease

Brudek

2019

JPD

101

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The etiology of Parkinson's disease (PD) is multifactorial, with genetics, aging, and environmental agents all a part of the PD pathogenesis. Widespread aggregation of the ␣-synuclein protein in the form of Lewy bodies and Lewy neurites, and degeneration of substantia nigra dopamine neurons are the pathological hallmarks of PD. Inflammatory responses manifested by glial reactions, T cell infiltration, and increased expression of inflammatory cytokines, as well as other toxic mediators derived from activated glial cells, are currently recognized as prominent features of PD. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD, and the increasing number of studies suggests that the condition may start in the gastrointestinal system years before any motor symptoms develop. Patients with inflammatory bowel disease (IBD) have a higher risk of developing PD compared with non-IBD individuals. Gene association study has found a genetic link between IBD and PD, and an evidence from animal studies suggests that gut inflammation, similar to that observed in IBD, may induce loss of dopaminergic neurons. Based on preclinical models of PD, it is suggested that the enteric microbiome changes early in PD, and gut infections trigger ␣-synuclein release and aggregation. In this paper, the possible link between IBD and PD is reviewed based on the available literature. Given the potentially critical role of gastrointestinal pathology in PD pathogenesis, there is reason to suspect that IBD or its treatments may impact PD risk. Thus, clinicians should be aware of PD symptoms in IBD patients.

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“…However, only four studies were included in the meta-analysis. We also noticed a case–control study by Camacho-Soto et al 3 reporting that the risk of PD was inversely associated with IBD (OR 0.85; 95% CI 0.80 to 0.91), which was not included in the meta-analysis by Zhu et al 2…”

mentioning

confidence: 91%

“…The study supported the theory that intestinal environment could influence the function of central nervous system which was also called the gut–brain axis. Recently, a meta-analysis by Zhu et al 2 suggested that the overall risk of PD in patients with IBD was significantly higher than controls (OR 1.41; 95% CI 1.19 to 1.66). However, only four studies were included in the meta-analysis.…”

mentioning

confidence: 99%