The Risk-of-Malignancy Index to Evaluate Potential Ovarian Cancers in Local Hospitals

Tingulstad, Solveig; Hagen, Bjørn; Skjeldestad, Finn Egil; Halvorsen, Tore; Nustad, Kjell; Onsrud, Mathias

doi:10.1097/00006250-199903000-00028

Cited by 195 publications

(221 citation statements)

References 14 publications

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“…In our study we found sensitivity 73.5%, specificity 97.1%, PPV 95.3% and NPV 82% by using RMI of more than 200. In the literature different values were defined for RMI and our results confirmed these studies (Jacobs et al, 1990;Davies et al, 1993;Tingulstad et al, 1999;Manjunath et al, 2001;Anderson et al, 2003;Ma et al, 2003;Obeidat et al, 2004;Yamamoto et al, 2009;Van der Akker et al, 2010;Ashrafgangooei et al, 2011;Van Gorp et al, 2012;Sayasneh et al, 2013;Terzic et al, 2013;Arun-Muthuvel et al, 2014).…”

Section: Discussionsupporting

confidence: 87%

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Role of a Risk of Malignancy Index in Clinical Approaches to Adnexal Masses

Simsek¹,

Tokmak²,

Özgü³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objective: The aim of this study was to evaluate predictive role of risk of malignancy index in discriminating between benign and malignant adnexal masses preoperatively. Methods: This retrospective study was conducted with a total of 569 patients with adnexal masses/ovarian cysts managed surgically at our clinic between January 2006 and January 2012. Obtained data from patient files were age, gravidity, parity, menopause status, ultrasound findings and CA125 levels. For all patients ultrasound scans were performed. For the assessment of risk of malignancy index (RMI) Jacobs' model was used. Histopathologic results of all patients were recorded postoperatively. Malignancy status of the surgically removed adnexal mass was the gold standard. Results: Of the total masses, 245 (43.1%) were malignant, 316 (55.5%) were benign and 8 (1.4%) were borderline. The mean age of benign cases was lower than malign cases (35.2±10.9 versus 50.8±13.4, p<0.001). Four hundred and five of them (71.2%) were in premenopausal period. Malignant tumors were more frequent in postmenopausal women (81% versus 29%, p<0.001). All ultrasound parameters of RMI were statistically significantly favorable for malignant masses. In our study ROC curve analysis for RMI provided maximum Youden index at level of 163.85. When we based on cutoff level for RMI as 163.85 sensitivity, specificity , PPV, NPV was calculated 74.7%, 96.2%, 94% and 82.6%, respectively. Conclusions: RMI was found to be a significant marker in preoperative evaluation and management of patients with an adnexal mass, and was useful for referring patients to tertiary care centers. Although utilization of RMI provides increased diagnostic accuracy in preoperative evaluation of patient with an adnexal mass, new diagnostic tools with higher sensitivity and specificity are needed to discriminate ovarian cancer from benign masses.

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Section: Discussionsupporting

confidence: 87%

“…Specificity and PPV for M were higher than the values reported in the literature (Jacobs et al, 1990;Tingulstad et al, 1999;Manjunath et al, 2001;Ma et al, 2003).…”

Section: Discussioncontrasting

confidence: 57%

Role of a Risk of Malignancy Index in Clinical Approaches to Adnexal Masses

Simsek¹,

Tokmak²,

Özgü³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Tingulstad et al [10] developed their version of the RMI in 1996, which is now known as RMI 2. In 1999, Tingulstad et al [11] modified the RMI, termed RMI 3. Yamamoto et al [12], who created their own model of a malignancy risk index, added the parameter of tumor size (S) to the RMI, and have termed it RMI 4.…”

Section: Jung-woo Park Et Al Four Rmis In Pelvic Massesmentioning

confidence: 99%

Four risk of malignancy indices in evaluation of pelvic masses

Park

Song

et al. 2012

Korean J Obstet Gynecol

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“…Similar studies showed that chance of malignancy in such cysts are very low about < 1% [17][18][19][20][21] .…”

Section: Discussionmentioning

confidence: 84%

Management of Postmenopausal Women with Simple Cyst

Nasreen¹

2017

Bangladesh J Obstet Gynaecol

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Introduction:Ovarian cysts in postmenopausal women are now known to be very common and maximum are not malignant. The exact prevalence is unknown given the limited amount of published data and the lack of established screening programs for ovarian cancer. However, studies have estimated the incidence to be anywhere between 5% and 17% 1-4 and 60-70% of unilocular cyst resolved spontaneously [5][6][7][8] . In Bangladesh we do not have exact data for the incidence but postmenopausal women with cysts are diagnosed as routine USG or in a woman who complains of slight discomfort in lower abdomen for any reason. Ovarian cancer remains the leading cause of death due to gynecological malignancy in many countries. Owing to very high mortality and severe morbidities, any postmenopausal woman is scared even with simple cyst. Before the era of USG if pelvic examination revealed palpable ovaries, those ovaries were removed. Now USG is able to detect cysts far before it becomes palpable and most of them are benign. Many women honor the ovaries and not happy to remove it. On the other hand once cysts are found in post menopausal women many women get frightened and request for the removal of cysts. So the gynecologist often faces the real challenge to treat Original Articles

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The Risk-of-Malignancy Index to Evaluate Potential Ovarian Cancers in Local Hospitals

Cited by 195 publications

References 14 publications

Role of a Risk of Malignancy Index in Clinical Approaches to Adnexal Masses

Role of a Risk of Malignancy Index in Clinical Approaches to Adnexal Masses

Four risk of malignancy indices in evaluation of pelvic masses

Management of Postmenopausal Women with Simple Cyst

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