The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis

Xiong, Yiquan; Chen, Yanxia; Cheng, Mingji; He, Wenqiao; Chen, Qing

doi:10.4103/aja.aja_77_17

Cited by 36 publications

(18 citation statements)

References 41 publications

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“…In this regard, many original studies, reviews and meta-analyses reported that HPV semen infection is related to reduced fertility both in natural and assisted conceptions. However, the exact mechanisms responsible for this condition have been never definitely assessed (16,19,31,33,39,44,45). Table 3 reports the main studies which investigated how HPV seminal infection in males may impair reproductive outcome in natural and/or assisted fertility.…”

Section: Hpv Semen Infection and Reproductive Outcomesmentioning

confidence: 99%

Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature

et al. 2021

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Infertility is an important health problem that affects up to 16% of couples worldwide. Male infertility is responsible for about 50% of the cases, and the various causes of male infertility may be classified in pre-testicular (for example hypothalamic diseases), testicular, and post-testicular (for example obstructive pathologies of seminal ducts) causes. Sexually transmitted infections (STI) are increasingly widely accepted by researchers and clinicians as etiological factors of male infertility. In particular, several recent reports have documented the presence of HPV in seminal fluid and observed that sperm infection can also be present in sexually active asymptomatic male and infertile patients. In this review, we aimed to perform a systematic review of the whole body of literature exploring the impact of HPV infection in natural and assisted fertility outcomes, from both an experimental and a clinical point of view. Starting from in-vitro studies in animals up to in-vivo studies in humans, we aimed to study and evaluate the weight of this infection as a possible cause of idiopathic infertility in males with any known cause of conception failure.

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Section: Hpv Semen Infection and Reproductive Outcomesmentioning

confidence: 99%

Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature

et al. 2021

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“…Among couples unable to conceive, infertility is to some extent attributable to a male factor in approximately 50% of cases [1, 3,4]. While occupation, environmental and genetic factors are recognized as important causes of male infertility for some time [3], virologic threats by human papillomavirus (HPV) infections have only recently been described [5][6][7]. Indeed, although HPV infection is one of the most common viral infections worldwide, it is almost exclusively linked with pathogenesis of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, although HPV infection is one of the most common viral infections worldwide, it is almost exclusively linked with pathogenesis of cancer. More recent studies have shown that male and couple subfertility may results from a HPV virion producing infection in one or both of the partners [6][7][8]. Also, the average lifetime probability of acquiring HPV among those with at least 1 opposite sex partner is more than 84.6% for women and 91.3% for men and more than 80% of women and men acquire HPV by age 45 years [9].…”

Section: Introductionmentioning

confidence: 99%

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Negative Impact of Elevated DNA Fragmentation and Human Papillomavirus (HPV) Presence in Sperm on the Outcome of Intra-Uterine Insemination (IUI)

Depuydt

Donders

Verstraete

et al. 2021

JCM

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We wanted to determine the sperm DNA fragmentation index (DFI) cutoff for clinical pregnancies in women receiving intra-uterine insemination (IUI) with this sperm and to assess the contribution of Human Papillomavirus (HPV) infection on sperm DNA damage and its impact on clinical pregnancies. Prospective non-interventional multi-center study with 161 infertile couples going through 209 cycles of IUI in hospital fertility centers in Flanders, Belgium. Measurement of DFI and HPV DNA with type specific quantitative PCRs (HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68) in sperm before its use in IUI. Clinical pregnancy (CP) rate was used as the outcome to analyze the impact on fertility outcome and to calculated the clinical cutoff value for DFI. A DFI criterion value of 26% was obtained by receiver operating characteristic (ROC) curve analysis. Couples with a male DFI > 26% had significantly less CPs than couples with DFI below 26% (OR 0.0326; 95% CI 0.0019 to 0.5400; p = 0.017). In sperm, HPV prevalence was 14.8%/IUI cycle. Sperm samples containing HPV had a significantly higher DFI compared to HPV negative sperm samples (29.8% vs. 20.9%; p = 0.011). When HPV-virions were present in sperm, no clinical pregnancies were observed. More than 1 in 5 of samples with normal semen parameters (17/78; 21.8%) had an elevated DFI or was HPV positive. Sperm DFI is a robust predictor of clinical pregnancies in women receiving IUI with this sperm. When DFI exceeds 26%, clinical pregnancies are less likely and in vitro fertilization techniques should be considered.

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“…In addition to genetic background and reproductive history, environmental factors and current lifestyle habits have been proposed as causes of male and female infertility [9]. According to large systematic reviews and meta-analyses, the lifestyle factors associated with reduced fertility are (1) sexually transmitted diseases, (2) psychological stress, (3) cigarette smoking, (4) alcohol use, (5) nutrition and diet, (6) physical activity and exercise, (7) underweight, (8) overweight and obesity, and (9) environmental pollutants [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Given the situation of one-third of Japanese couples currently or previously worrying about infertility, for those who are trying to conceive or hope to have a child in the future, knowledge about the lifestyle factors associated with reduced fertility may help to prevent infertility.…”

Section: Introductionmentioning

confidence: 99%

Online Japanese-Language Information on Lifestyle Factors Associated With Reduced Fertility: Content Analysis (Preprint)

Yokota¹,

Okuhara²,

Ueno³

et al. 2020

Preprint

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BACKGROUND Approximately one-third of Japanese couples currently worry or previously worried about infertility. To develop strategies for the primary prevention of infertility as a population approach, it is important for the general population to be knowledgeable about fertility and infertility. The internet may contribute to the dissemination of information regarding infertility and fertility. However, few studies have examined online information about fertility. OBJECTIVE This study aimed to quantitatively examine online Japanese-language information about lifestyle factors associated with reduced fertility. METHODS We conducted online searches, using the 10 search terms with the highest numbers of searches that people hoping to conceive are likely to input in two major search engines in Japan (Google Japan and Yahoo! Japan). From the 2200 retrieved websites, 1181 duplicates and 500 websites unrelated to our objective were excluded, resulting in a final dataset of 519 websites. Coding guidelines were developed for the following lifestyle factors associated with reduced fertility: sexually transmitted diseases, psychological stress, cigarette smoking, alcohol use, nutrition and diet, physical activity and exercise, underweight, overweight and obesity, and environmental pollutants. RESULTS In terms of the website author’s professional expertise, 69.6 % of the coding instances for the selected lifestyle factors were mentioned by hospitals, clinics, or the media, whereas only 1.7% were mentioned by laypersons. Psychological stress (20.1%) and sexually transmitted diseases (18.8%) were the most frequently mentioned lifestyle factors associated with reduced fertility. In contrast, cigarette smoking, alcohol use, nutrition and diet, physical activity and exercise, underweight, overweight and obesity, and environmental pollutants were mentioned relatively infrequently. The association between reduced fertility and sexually transmitted diseases was mentioned significantly more frequently by hospitals and clinics than by the media (P<.001). The association between reduced fertility and nutrition and diet was mentioned significantly more frequently by the media than by hospitals and clinics (P=.008). With regard to the sex of the target audience for the information, female-specific references to psychological stress, sexually transmitted diseases, nutrition and diet, underweight, physical activity and exercise, and overweight and obesity were significantly more frequent than were male-specific references to these lifestyle factors (psychological stress: P=.002, sexually transmitted diseases: P<.001, nutrition and diet: P<.001, underweight: P<.001, physical activity and exercise: P<.001, overweight and obesity: P<.001). CONCLUSIONS Of the lifestyle factors known to be related to reduced fertility, cigarette smoking, alcohol use, and male-specific lifestyle factors are mentioned relatively infrequently in online information sources in Japan, and these factors should be discussed more in information published on websites.

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The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis

Cited by 36 publications

References 41 publications

Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature

Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature

Negative Impact of Elevated DNA Fragmentation and Human Papillomavirus (HPV) Presence in Sperm on the Outcome of Intra-Uterine Insemination (IUI)

Online Japanese-Language Information on Lifestyle Factors Associated With Reduced Fertility: Content Analysis (Preprint)

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