The risk of depression and anxiety in patients with familial mediterranean fever – a cross-sectional study

Lidor, Inbar; Tiosano, Shmuel; Sharif, Κassem; Amital, Howard; Cohen, Arnon D; Amital, Daniela

doi:10.1016/j.jad.2021.05.113

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…No significant difference was found between FMF patients living in Germany and Turkey in terms of depression and anxiety. Lidor et al (23) from Israel, consisting of 7670 FMF patients and a control group of 7670 people and using the depressive illness, anxiety disorders and FMF diagnosis codes in the patient registry system, the prevalence of depression was found to be higher than the control group. (6.22% vs 4.58%, p<0.001).…”

Section: Discussionmentioning

confidence: 99%

Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

ŞAHİNOĞLU,

YILDIRIM ÇETİN

2023

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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ABSTRACT Aim: Familial Mediterranean Fever (FMF) is an autosomal recessive and self-limiting disease. FMF is characterized by recurrent episodes of fever, peritonitis, synovitis and pleuritis. Individuals with chronic illness tend to experience depression or anxiety. It has also been stated that affective temperaments are the basis of mood disorders. The aim of our study is to determine the frequency of anxiety and depression in FMF patients, to determine the dominant temperament type, and to compare the findings with the healthy control group. Method: 73 patients with FMF and 30 age- and gender-matched healthy individuals without any systemic disease were included in the study. The hospital anxiety and depression scale were used to measure depression and anxiety, and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego –Autoquestionnaire (TEMPS-A) temperament scale was used to determine the temperament type. Results: The number of cases diagnosed with anxiety was 33 (45.2%) in the patient group and 5 (16.6%) in the control group; The number of cases diagnosed with depression was 23 (31.5%) in the patient group and 2 (6.6%) in the control group, and both were also found to be statistically significantly higher. (P values p=0.02 and p=0.002, respectively) No statistically significant correlation was found between gender, age, disease duration, regular use of treatment, presence of gene mutation and attack type, and anxiety and depression scores. According to the TEMPS-A temperament scale, the percentage of patients diagnosed with depressive temperament (20.5%) was higher than the control group (3.3%), and the difference was statistically significant. (p=0.02). Conclusion: When the clinical picture in FMF patients becomes complicated with anxiety or depression or in the presence of a temperament predisposed to these conditions, there may be various problems in patients' compliance and response to treatment. FMF patients should be monitored for accompanying anxiety or depression during follow-up. Key Words: Anxiety, Depression, Familial Mediterranean Fever, Temperament

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Section: Discussionmentioning

confidence: 99%

Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

ŞAHİNOĞLU,

YILDIRIM ÇETİN

2023

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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“…8 Multivaryant lojistik regresyon analizi kullanılarak yapılan başka bir çalışmada, benzer şekilde anksiyete ve depresyon AAA ile ilişkili bulundu. 33 Deger ve ark.nın yaptığı başka bir çalışmada ise sadece anksiyetenin AAA ile bağlantılı, fakat depresyonun tek başına AAA ile ilişkisiz olduğu, fakat anksiyete varlığının depresyona katkıda bulunduğu saptandı. 6 Ülkemizde HAD alt ölçekleri kullanılarak yapılan çalışmada, AAA hastalarında diğer çalışmalara benzer şekilde daha yüksek oranda anksiyete ve depresyon saptandı ve korelasyon analizinde Ailesel Akdeniz ateşine özgü geliştirilmiş yaşam kalitesi skoru ile HAD skorları arasında da pozitif korelasyon gösterildi.…”

Section: Discussionunclassified

The Effect of Gender on Depression, Anxiety, and Quality of Life in Familial Mediterranean Fever

KONAK,

ATALAR,

ORHAN

2023

J PMR Sci

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ÖZET Amaç: AAA (Ailevi Akdeniz Ateşi) hastalarında diğer kronik hastalıklarda olduğu gibi depresyon,anksiyete ve uyku bozukluğu sıklığı artmıştır. Ancak cinsiyetin depresyon, anksiyete ve yaşam kalitesine olan etkisi net olarak araştırılmamıştır. Bu çalışmanın amacı; AAA hastalarında cinsiyetin, hastalık klinik özellikleri ve hastalık aktivitesi ve Hospital Anxiety and Depression Scale (HADS) ve Nottingham Health Profile (NHP) kullanılarak anksiyete, depresyon ve yaşam kalitesi parametreleri üzerine etkisini incelemektir. Gereç ve Yöntemler: Çalışmamıza dahil edilen AAA hastaların hastalık başlama yaşı, hastalık süresi,1 yıldaki atak sayısı, atak özellikleri, amiloidoz varlığı, MEFV gen mutasyonu sonucu, AAA için aldıkları medikal tedaviler ve International Severity Scoring System (ISSF) not edildi. Hastaların ağrı ve yorgunluk düzeyleri visüel analog skala (VASağrı/VAS-yorgunluk) ile ölçüldü. HAD-anksiyete ve HAD-depresyon skalası, AAA hastalarının anksiyete ve depresyon düzeyini ve şiddetini, NHP ölçeği yaşam kalitesini değerlendirmek için kullanıldı. Bulgular: Hastalar cinsiyetine göre iki gruba ayrıldığında, yaş ortalaması, VKİ, medeni durumu, eğitim durumu ve sigara kullanımı açısından aralarında istatistiksel olarak anlamlı farklılık yoktu (sırasıyla p=0.218, p=0.383, p=0.505, p=0.246 ve p=0.411). Hastaların cinsiyetine göre HAD-depresyon ve HAD-anksiyete skorları karşılaştırıldığında kadın hastaların erkek hastalara göre depresyon ve anksiyete skorları istatistiksel olarak anlamlı bulundu (sırasıyla p=0.01, p=0.04). Kadın AAA hastalarında erkek hastalara göre NHP uyku ve emosyonel reaksiyon skorları istatistiksel olarak anlamlı ölçüde daha yüksek bulundu (sırasıyla p=0.027, p=0.033). Sonuç: Çalışmamızda, her iki cinsiyette benzer hastalık aktivitesi durumunda dahi; kadın AAA hastalarında erkeklere göre daha çok depresyon, anksiyete, uyku bozukluğu ve sosyal izolasyon gözlenmiştir (sırasıyla p=0.01, p=0.04, p = 0.027 ve 0.033). Bu nedenle hastalığın bu açıdan değerlendirilmesi yararlı olacaktır. Anah tar Ke li me ler: Ailevi Akdeniz ateşi; anksiyete; depresyon ABS TRACT Objective:The aim of this study is to examine the effect of gender on the parameters of anxiety, depression and quality of life in FMF patients using the disease clinical features and disease activity and the Hospital Anxiety and Depression Scale (HADS) and the Nothingam Health Profile (NHP). Material and Methods: Age of onset of disease, duration of disease, number of attacks per year, attack characteristics, presence of amyloidosis, MEFV gene mutation result and the International Severity Scoring System (ISSF) were noted. HAD-anxiety and HAD-depression scales were used to evaluate the level and severity of anxiety and depression and the NHP scale was used to evaluate quality of life. Results: When the patients were divided into two groups according to their gender, there was no statistically significant difference between them in terms of mean age, marital status, educational status, and smoking (p=0. 218, p=0.505, p=0.246, and p=0.411, r...

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“…Many diseases are accompanied by uncomfortable symptoms, such as fever, pain, and inflammation. Individuals with familial Mediterranean fever ( 33 ), chronic pain ( 34 ), and an increased inflammatory response (augmentation of interleukin-6, C-reactive proteins, and fibrinogen blood levels) ( 35 ) will experience anxiety symptoms at higher rates than the general population. In addition, dry eye disease may lead to emotional disorders such as anxiety due to the long-term symptoms of eye irritation ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Depression and anxiety of medical students at Kunming Medical University during COVID-19: A cross-sectional survey

Guo

Zhang

et al. 2022

Front. Public Health

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An isolation strategy was used to control the transmission and rapid spread of COVID-19 in Yunnan. As a result, students were supposed to stay at home and disrupted their outside activities. It led to a detrimental influence on students' mental health. The purpose of this study was to investigate the prevalence and risk factors of depression and anxiety among medical students and to provide ideas for the prevention of depression and anxiety in medical students. A cross-sectional survey was conducted among 2,116 medical students at Kunming Medical University from July 8 to July 16, 2020. Participants' demographic and living conditions were collected. Depression and anxiety were measured using the Patient Health Questionnaire 9 and General Anxiety Disorder-7, respectively. Uni- and multivariate logistic regression analyses were performed to detect risk factors associated with depression and anxiety. The prevalence rates of depression and anxiety among medical students were 52.5 and 29.6%, respectively. Depression was more likely to be caused by low grades, lack of physical exercise, drug use, irregular diet, extensive screen time on mobile phones, being greatly affected by the COVID-19 pandemic, and inadaptability to offline courses. Anxiety was more likely to be caused by lack of physical exercise, drug use, irregular diet, and inadaptability to offline courses. Depression and anxiety are highly comorbid. Our study showed predictive factors for depression and anxiety and identified a major mental health burden on medical students during the COVID-19 outbreak. More targeted measures should be taken to improve the mental state of students to reduce the incidence of depression and anxiety.

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The risk of depression and anxiety in patients with familial mediterranean fever – a cross-sectional study

Cited by 6 publications

References 40 publications

Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

The Effect of Gender on Depression, Anxiety, and Quality of Life in Familial Mediterranean Fever

Depression and anxiety of medical students at Kunming Medical University during COVID-19: A cross-sectional survey

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