The risk of dental restoration-related lead exposure on renal function

Sun, Wenhai; Dai, Bichong; Li, Hong; Zhang, H.

doi:10.1016/j.chemosphere.2023.139405

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Accompanied with attachment loss, severe periodontitis caused serious aesthetic problems and reduced chewing efficiency [ 16 , 17 ]. Previous studies suggested that the progression of attachment loss was accompanied with increasing circulatory immunological indexes in severe periodontitis [ 13 , 14 ], but immune cell counts serve as forewarning or diagnostic criteria for severe attachment loss or periodontitis progression remains unclear.…”

Section: Discussionmentioning

confidence: 99%

The indicative role of inflammatory index in the progression of periodontal attachment loss

Zhang,

Jin

et al. 2023

Eur J Med Res

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Objective To explore the forewarning immunological indicators during periodontal attachment loss progression in American adults. Methods A total of 5744 participants with periodontal attachment loss were enrolled from the National Health and Nutrition Examination Surveys (NHANES) 2009–2014. In which, dependent variable was the counts of teeth with severe attachment loss (depth of periodontal probing was above 5 mm). Independent variables were circulatory immunological indexes, including counts of white blood cells (WBC), Lymphocytes, Monocytes, Neutrophils, Eosinophils, and Basophils. The association among variables was examined using multivariable linear regression models, fitting with smoothing curves, and generalizing additive models. Results Based on the indicators of 5744 subjects, we found that severe attachment loss tended to occur in the elderly or males and was accompanied by higher WBC, Monocytes, and Neutrophils, as well as lower poverty-income ratio and educational qualification. WBC (above the inflection point: 6200 cells/µL) and Neutrophils (above the inflection point: 3300 cells/µL) counts were positively associated with attachment loss progression in each multivariable linear regression model. On subgroup analyses, stratified by sex and race, the positive correlation of WBC or Neutrophils with severe attachment loss was stable in both men and women, as well as in all races except blacks (WBC β = − 0.0576, 95% CI − 0.1945 to 0.0793, Neutrophils β = − 0.0527, 95% CI − 0.2285 to 0.1231). Conclusion Increasing WBC (above 6200 cells/µL) and Neutrophils (above 3300 cells/µL) counts were risk indicators of severe periodontal attachment loss among all races, except in blacks.

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