The risk of deliberate self-harm following a diagnosis of rheumatoid arthritis or ankylosing spondylitis: A population-based cohort study

Kuriya, Bindee; Vigod, Simone N.; Luo, Jin; Widdifield, Jessica; Haroon, Nigil

doi:10.1371/journal.pone.0229273

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…Kuriya et al showed that patients with RA tend to self-injure 1.4 times more than those without the disease, the most common method used to injure themselves was through the ingestion of poisons followed by the use of sharp objects. 26 …”

Section: Search Methodologymentioning

confidence: 99%

“…25 Kuriya et al showed that patients with RA tend to selfinjure 1.4 times more than those without the disease, the most common method used to injure themselves was through the ingestion of poisons followed by the use of sharp objects. 26 Treharne et al showed that approximately 11% of patients with RA have manifested suicidal thoughts according to the Nottingham Health Profile (NHP), of which those who had a longer duration of the disease (> 4 years) were more likely to manifest them than those with an earlier disease course (<2 years). 27 Li et al along with Treharne et al found that suicidal ideas were more prevalent in females in 11.7% to 14%, compared to males with 0.0% and 3%, 27,28 the mean age was 56 years and the mean duration of the disease was approximately 10.9 years.…”

Section: Suicidal Behavior In Rheumatoid Arthritismentioning

confidence: 99%

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Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

Espinoza¹,

Maldonado²,

Narvaez³

et al. 2021

OARRR

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Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune systemic disease that preferentially affects small and large joints with a progressive course and can become deforming and disabling. In recent years, much progress has been made in the evaluation of inflammation and disease activity, however, there are other factors that have a high impact on the quality of life of these patients, such as depression, anxiety, fatigue, sleep disorders, suicidal behavior, fibromyalgia, sexual activity, sarcopenia, frailty, cachexia and obesity that are not always evaluated by rheumatologists. This review shows that the evaluation and timely detection of these aspects in patients with RA could interfere with the prognosis and improve their quality of life.

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Section: Search Methodologymentioning

confidence: 99%

Section: Suicidal Behavior In Rheumatoid Arthritismentioning

confidence: 99%

Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

Espinoza¹,

Maldonado²,

Narvaez³

et al. 2021

OARRR

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“…AS carries an increased risk of serious mental health issues such as self-harm but no such risk was observed in RA. 11 Prior literature from other countries has reported the various predictors of psychological distress among axSpA patients, including high disease activity, decreased functionality, 6 impaired QoL, 9 poor work productivity, 10 fatigue, 12 and sleep disturbances. 13 However, due to differences in the cultural and social dynamics of India, 14 there is a need to verify whether the same predictive factors are applicable for Indians.…”

Section: Introductionmentioning

confidence: 99%

Anxiety and depression among patients with axial spondyloarthritis

Reddy¹,

Sabu²,

Pandey³

et al. 2022

Eur J Rheumatol

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Objective: The axial spondyloarthritis (axSpA) mainly affects young population and often leads to reduced mobility, but less is known about the impact it has on mental health. The objective of this study was to determine the prevalence of symptoms of anxiety and depression among axSpA patients and explore the underlying associated factors. Methods: A cross sectional survey-based study was conducted from a single center. A convenient sampling was done to include 100 patients. We included questions about disease activity, sleep, fatigue, quality of life (QoL), and work productivity. All patients were asked to fill the patient health questionnaire-9 (PHQ) for depression and general anxiety disorder-7 (GAD) for anxiety. A multivariate binomial logistic regression analysis was performed to determine associations between PHQ-9 and GAD-7 scores with various socio-demographic factors, disease activity scores, and other variables. Results : Clinically significant symptoms of anxiety and depression were present in 38% and 36% patients, respectively. Both were significantly associated with younger age at disease onset ( P < .05), high disease activity, sleep disturbances, fatigue, poor QoL, and high impact on work productivity. Misbeliefs that “doctors hide side-effects of medicines” and “all modern medicine used in treatment of axSpA causes side-effects” were also related to higher anxiety and depression scores. Depression was also found to be associated with female patients. Conclusion: Anxiety and depression are common in axSpA. They are associated with high disease activity and reduced work productivity. Patients should be regularly screened for these symptoms.

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“…It carries a considerable mental health burden; incidence estimates suggest risk of depression is 51% higher in people with AS compared to individuals without AS [ 2 ], while in those newly diagnosed, the risk is higher still – twofold that of the general population [ 3 ]. Furthermore, being diagnosed with axial Spondyloarthritis (axial SpA) increases risk of deliberate self-harm by 59% compared to non-diagnosed individuals [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the emotional impact of axial Spondyloarthritis: a systematic review and thematic synthesis of qualitative studies and a review of social media

Wilson,

Liu,

Adamjee

et al. 2023

BMC Rheumatol

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Background The psychological burden in people with inflammatory arthritis is substantial, yet little is known about the disease-related affect experienced by individuals with axial Spondyloarthritis (axial SpA). The aim of this study was to conduct a qualitative evidence synthesis and a review of social media to explore the emotional impact of living with axial SpA. Methods We searched nine databases for studies reporting qualitative data about participants’ emotional experience of living with axial SpA. In addition, we searched social media platforms for posts from people with axial SpA based in the UK that offered insights into emotional responses to living with the condition. We employed a thematic approach to synthesise the data. Results We included 27 studies (1314 participants; 72% men) in our qualitative evidence synthesis and developed seven descriptive themes from the data: 1) delayed diagnosis: a barrier to emotional wellbeing; 2) disruptive symptoms: a source of mood swings; 3) work disability: a loss of self-esteem; 4) obstacles in interpersonal relationships: a trigger of distress; 5) taking up exercise: personal pride or unwelcomed reminders; 6) anti-TNF therapy: hope reignited despite concerns and 7) a journey of acceptance: worry mixed with hope. Posts extracted from social media fora (537; 48% from women) for the most part supported the seven themes. One additional theme—COVID-19, uncertainty and anxiety during the pandemic, was developed, reflecting common emotions expressed during the UK’s first wave of the coronavirus pandemic. Conclusion This study highlights a preponderance of negative affect experienced by people living with axial SpA, conditioned through existing and anticipated symptoms, failed expectations, and lost sense of self. Given the bidirectional relationships between negative emotions and inflammation, negative emotions and perceptions of pain, and the influence of affect in self-care behaviours, this finding has important implications for treatment and management of people with axial SpA.

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The risk of deliberate self-harm following a diagnosis of rheumatoid arthritis or ankylosing spondylitis: A population-based cohort study

Cited by 8 publications

References 39 publications

Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

Beyond Rheumatoid Arthritis Evaluation: What are We Missing?

Anxiety and depression among patients with axial spondyloarthritis

Exploring the emotional impact of axial Spondyloarthritis: a systematic review and thematic synthesis of qualitative studies and a review of social media

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