The risk of cytomegalovirus infection in daycare workers: a systematic review and meta-analysis

Starke, Karla Romero; Kofahl, Marlen; Freiberg, Alice; Schubert, Melanie; Groß, Mascha Luisa; Schmauder, Stefanie; Hegewald, Janice; Kämpf, Daniel; Stranzinger, Johanna; Nienhaus, Albert; Seidler, Andreas

doi:10.1007/s00420-019-01464-x

Cited by 21 publications

(21 citation statements)

References 35 publications

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“…and S.F.) assessed the risk of bias as high, low, or unclear against eight domains of bias, using a tool previously used for other occupational health reviews [ 20 , 21 , 22 , 23 ]. The hybrid tool uses SIGN (Scottish Intercollegiate Guidelines Network 2004) and CASP (Critical Appraisal Skills Program 2004/2006) assessment tools and contains several domains for risk of bias.…”

Section: Methodsmentioning

confidence: 99%

“…The hybrid tool uses SIGN (Scottish Intercollegiate Guidelines Network 2004) and CASP (Critical Appraisal Skills Program 2004/2006) assessment tools and contains several domains for risk of bias. Examples of reviews using this tool have been published previously [ 20 , 21 , 24 ], and the Risk of Bias tool can be found in the Supplementary Materials .…”

Section: Methodsmentioning

confidence: 99%

“…To assess the quality of the total body of evidence, we used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach [ 33 ], following the example of Hulshof and colleagues [ 34 ], with some modifications [ 20 , 21 , 24 ]. We used three levels of quality: high, moderate, and low.…”

Section: Methodsmentioning

confidence: 99%

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Are Healthcare Workers at an Increased Risk for Obstructive Respiratory Diseases Due to Cleaning and Disinfection Agents? A Systematic Review and Meta-Analysis

Starke

Friedrich

Schubert

et al. 2021

IJERPH

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Several reviews have reported an increased risk of obstructive respiratory diseases in workers exposed to cleaning or disinfection agents, but they have focused mainly on professional cleaners. Cleaning and disinfecting are frequently performed activities by healthcare workers. We conducted a systematic review with meta-analysis to quantify the risk of obstructive respiratory diseases in healthcare workers exposed to cleaning and disinfection agents. We searched the Medline and Embase databases until 4 February 2021 to find adequate primary studies. Two independent reviewers screened the titles/abstracts and the full texts of the studies, as well as performing data extraction and quality assessment. The literature search yielded 9432 records, and 8 studies were found through a hand search. After screening, 14 studies were included in the review. All had a high risk of bias, and most studies dealt with nurses, asthma, and hyperresponsiveness (BHR)-related symptoms. Only one study investigated COPD. The meta-analysis estimated an increased risk of new-onset asthma for nurses (Effect size (ES) = 1.67; 95% CI 1.11–2.50) compared with other occupations and found an increase in the risk of new-onset asthma for nurses exposed to cleaning and disinfecting surfaces (ES = 1.43; 95% CI 1.09–1.89) and instruments (ES = 1.34; 95% CI 1.09–1.65). Exposure to specific chemicals such as bleach and glutaraldehyde (GA) increased the risk of asthma in nurses (bleach ES = 2.44; 95% CI 1.56–3.82; GA ES = 1.91, 95% CI 1.35–2.70). A higher risk for BHR-related symptoms was observed for nurses exposed to cleaning surfaces (ES = 1.44; 95% CI 1.18–1.78). Although the overall evidence was rated as low, the limitations found in this review hint at a potential underestimation of the real risk. These findings highlight the need for reinforced prevention practices with regard to healthcare workers. Similar research investigating these associations among other healthcare workers such as rescue service and nursing home personnel is needed.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Are Healthcare Workers at an Increased Risk for Obstructive Respiratory Diseases Due to Cleaning and Disinfection Agents? A Systematic Review and Meta-Analysis

Starke

Friedrich

Schubert

et al. 2021

IJERPH

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“…The risk of bias was assessed by two reviewers using a schema used previously for other occupational reviews [ 38 , 39 ] and adapted for the current research question ( Supplementary Table S7 ). We considered study characteristics pertaining to study recruitment and follow-up, exposure measurements, outcome assessment, consideration of confounding and effect modification, analysis methods, and chronology to be domains of major importance regarding bias.…”

Section: Methodsmentioning

confidence: 99%

Occupational Noise and Hypertension Risk: A Systematic Review and Meta-Analysis

Bolm‐Audorff

Hegewald

Pretzsch

et al. 2020

IJERPH

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A number of epidemiological studies report an association between occupational noise exposure and arterial hypertension. Existing systematic reviews report conflicting results, so we conducted an updated systematic review with meta-analysis. We registered the review protocol with PROSPERO (registration no.: CRD 42019147923) and searched for observational epidemiological studies in literature databases (Medline, Embase, Scopus, Web of Science). Two independent reviewers screened the titles/abstracts and full texts of the studies. Two reviewers also did the quality assessment and data extraction. Studies without adequate information on recruitment, response, or without a comparison group that was exposed to occupational noise under 80 dB(A) were excluded. The literature search yielded 4583 studies, and 58 studies were found through hand searching. Twenty-four studies were included in the review. The meta-analysis found a pooled effect size (ES) for hypertension (systolic/diastolic blood pressure ≥140/90 mmHg) due to noise exposures ≥80 dB(A) of 1.81 (95% CI 1.51–2.18). There is no substantial risk difference between men and women, but data concerning this question are limited. We found a positive dose-response-relationship: ES = 1.21 (95% CI 0.78–1.87) ≤ 80 dB(A), ES = 1.77 (95% CI 1.36–2.29) > 80–≤85 dB(A), and ES = 3.50 (95% CI 1.56–7.86) > 85–≤90 dB(A). We found high quality of evidence that occupational noise exposure increases the risk of hypertension.

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“…Given that parity is a proxy variable for the number of children at home, our finding is similar to previous reports [ 26 ] in that seroprevalence is positively correlated with the number of close child contacts ( Table 1 ). Exposure to young children, who shed CMV at high viral loads in saliva and urine for prolonged periods when infected, is a known risk factor for CMV infection [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec

et al. 2021

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Introduction Maternal Cytomegalovirus (CMV) infection in the first trimester (T1) of pregnancy is a public health concern, as it increases the risk of severe neurodevelopmental outcomes associated with congenital infection compared to infections occurring later during pregnancy. Objectives To determine CMV seroprevalence in T1 of pregnancy, its trend, risk factors and the incidence rate of primary infection during pregnancy. Methods Using the biobank of the prospective cohort “Grossesse en Santé de Québec” collected between April 2005 and March 2010 at the Québec-Laval Hospital, Québec, Canada, maternal CMV serology was determined using Abbott Architect Chemiluminescence microparticle immunoassays for immunoglobulin G(IgG), immunoglobulin M(IgM) titration and IgG avidity testing. Changepoint detection analysis was used to assess temporal trends. Risk factors associated with seropositivity were determined by multivariable logistic regression. Results CMV seroprevalence in T1 of pregnancy was 23.4% (965/4111, 95% CI, 22.1–24.7%). The incidence rate for CMV primary infection during pregnancy was 1.8 (95% CI, 1.2–2.6) per 100 person-years. No changepoint was identified in the maternal CMV-seroprevalence trend. Multivariable analyses showed that T1 maternal CMV seropositivity was associated with having one child OR 1.3 (95% CI, 1.10–1.73) or two or more children OR 1.5 (95%CI, 1.1–2.1), ethnicity other than Caucasian OR 2.1 (95% CI, 1.1–3.8) and country of birth other than Canada and the USA OR 2.8 (95% CI, 1.5–4.9). Conclusions In this cohort, maternal seroprevalence in T1 of pregnancy and seroconversion rate were low. This information and identified risk factors could help guide the development and implementation of preventive actions and evidence-based health policies to prevent CMV infection during pregnancy.

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The risk of cytomegalovirus infection in daycare workers: a systematic review and meta-analysis

Cited by 21 publications

References 35 publications

Are Healthcare Workers at an Increased Risk for Obstructive Respiratory Diseases Due to Cleaning and Disinfection Agents? A Systematic Review and Meta-Analysis

Are Healthcare Workers at an Increased Risk for Obstructive Respiratory Diseases Due to Cleaning and Disinfection Agents? A Systematic Review and Meta-Analysis

Occupational Noise and Hypertension Risk: A Systematic Review and Meta-Analysis

Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec

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