The risk of cytogenetic abnormalities in the late first trimester of pregnancies conceived through assisted reproduction

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos

“…Yet in humans, studies are scarce and less conclusive. In this context when comparing natural and stimulated cycles, no differences have been observed in terms of cleavage capacity [3], oocyte [4], and embryo aneuploidy rate [5], or incidence of aneuploidy in either aborted foetuses [6] or chorionic villus sampling late in the first trimester of pregnancy [7]. …”

Pregnancy outcomes in very advanced maternal age pregnancies: the impact of assisted reproductive technology

“…Assisted reproductive technology has been associated with adverse pregnancy outcomes, including earlier delivery of pregnancies, low birth weight, very low birth weight, preterm delivery, and other potential complications associated with abnormal placentation (15,16), but not cytogenetic genetic abnormalities, in AMA women compared with spontaneous conceptions (17). More recently, studies have emerged that the underlying infertility and time to pregnancy are risk factors for adverse pregnancy outcomes, independent of maternal age (18).…”

The effect of infertility and assisted reproduction on first-trimester placental and fetal development

“…Although the majority of children born through fertility treatments are healthy, these treatments have been associated with adverse pregnancy outcomes including but not limited to preeclampsia, placental abruption, placenta previa, preterm labor and delivery, and low birth weight (3)(4)(5)(6)(7)(8)(9). Although several studies have reported increased risks, it does not appear to be related to an increased risk of cytogenetic abnormalities in pregnancies conceived by assisted reproduction technologies (ART) (10,11). Thus, it has not been fully elucidated how and when these changes are initiated.…”