The risk factors of persistent thrombocytopenia and splenomegaly after liver transplantation

Matsuura, Toshiharu; Hayashida, Miyeko; Saeki, Isamu; Taguchi, Tomoaki

doi:10.1007/s00383-010-2660-z

Cited by 14 publications

(11 citation statements)

References 11 publications

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“…A splenectomy is preferred when the PLT count does not increase after the transfusion of 12-24 units of PLT or decreases to the original lowest count 1-2 days after the transfusion [11]. Mastuura et al [12]. suggested that a high postoperative PLT count was also a risk factor for decreased survival, and therefore the patient should be monitored for a high PLT count postoperatively [13,14] and proper treatment should be administrated when necessary.…”

Section: Discussionmentioning

confidence: 99%

Grading of Peripheral Cytopenias Caused by Nonalcoholic Cirrhotic Portal Hypertension and Its Clinical Significance

Lv¹,

Han²,

Gong³

et al. 2014

Cell Biochem Biophys

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This study investigates peripheral cytopenias in patients with splenomegaly caused by nonalcoholic cirrhotic portal hypertension. Data from 330 splenomegaly cases caused by nonalcoholic cirrhotic portal hypertension were collected and analyzed using univariate and multivariate analysis. The cytopenias were scored and graded according to the F value of the multiple linear regression equation. Based on the severity of thrombocytopenia, cytopenia was graded as mild, moderate, or severe, and determined by a score of <2 points, 2-3 points, and >3 points. 30 % of the patients had monolineage cytopenias, 35.8 % had bilineage cytopenias, and 34.2 % had trilineage cytopenias. All patients were treated surgically. In the univariate analysis, the severity of erythropenia was different in the surgical outcome when compared to the intra-group (P < 0.05). In the multivariate analysis, thrombocytopenia was different in the surgical outcomes when compared with leukopenia and erythropenia (P < 0.05). There was a significant difference in surgical outcomes between the three grades (mild, moderate, and severe) of cytopenia (P < 0.05). Peripheral cytopenias have a significant impact on the clinical outcomes. The more severe the cytopenias, the worse the surgical outcomes are. Thrombocytopenia is a major factor influencing surgical outcomes. The thrombocytopenia-based three-level grading of cytopenias provides a basis for analyzing individual cases, planning treatment, and assessing prognosis in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Grading of Peripheral Cytopenias Caused by Nonalcoholic Cirrhotic Portal Hypertension and Its Clinical Significance

Lv¹,

Han²,

Gong³

et al. 2014

Cell Biochem Biophys

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show abstract

“…Preoperative PLT transfusion is required to elevate the PLT count to above 50×10 9 /L. An increased postoperative PLT count has also been demonstrated to be a risk factor [19,20].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Risk Factors for Surgery in Patients with Cirrhotic Portal Hypertension

Lv¹,

Lau²,

Han³

et al. 2014

J Hypertens

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This study excluded patients with non-cirrhotic portal hypertension, such as regional portal hypertension, patients with no evidence of splenomegaly or hematocytopenia of one or multiple cell lines in the circulatory blood. Clinical data Of the 161 patients enrolled, 97 were male and 64 female (male: female=1.5:1). The ages of patients ranged from 10 to 64 years and averaged 42 years. One hundred twenty-two patients had liver cirrhosis secondary to HBV-hepatitis, 26 patients had liver cirrhosis secondary to HCV-hepatitis, 5 had biliary cirrhosis, 3 had alcoholic cirrhosis, 2

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“…These types of patients are suitable for splenectomy [25] . Mastuura et al [26] suggested that the excessive postoperative PLT count was also a life-threatening factor, so the condition of the patient should be closely monitored [27][28] when there is excessive platelet count, appropriate treatment should be administrated immediately. …”

Section: Hemocytopenia In Peripheral Blood and Its Prognosismentioning

confidence: 99%

Changes of Peripheral Blood Cells in Patients with Cirrhotic Portal Hypertension

Lv¹

2012

Portal Hypertension - Causes and Complications

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The risk factors of persistent thrombocytopenia and splenomegaly after liver transplantation

Abstract: The evaluation of the pre-transplant spleen volumes and the platelet counts before LT thus makes it possible to predict the persistent thrombocytopenia after LT.

Cited by 14 publications

References 11 publications

Grading of Peripheral Cytopenias Caused by Nonalcoholic Cirrhotic Portal Hypertension and Its Clinical Significance

Grading of Peripheral Cytopenias Caused by Nonalcoholic Cirrhotic Portal Hypertension and Its Clinical Significance

Prognostic Risk Factors for Surgery in Patients with Cirrhotic Portal Hypertension

Changes of Peripheral Blood Cells in Patients with Cirrhotic Portal Hypertension

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