The risk factors for mechanical complication in endoprosthetic reconstruction of knee osteosarcoma

Karaismailoğlu, Bedri; Özşahin, Mahmut Kürşat; Görgün, Barış; Değer, Göker Utku; Hız, Murat

doi:10.1016/j.knee.2021.10.014

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…However, cement fixation often leads to frequent aseptic loosening and osteolysis, and it is extremely difficult to completely remove the bone cement during revision surgery. [17][18][19] A study including 115 patients with bone metastases in the extremities who underwent resection and reconstruction with cemented or uncemented endoprostheses showed the stem loosening rates of the cemented and uncemented groups did not differ statistically. On the other hand, significantly higher number of stem loosening areas was observed after cemented reconstructions compared to uncemented endoprostheses at last follow-up.…”

Section: Prosthetic Fixation Methodsmentioning

confidence: 99%

Application and Development of Megaprostheses in Limb Salvage for Bone Tumors Around the Knee Joint

Zhang

2022

Cancer Control

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In recent decades, limb-salvage surgery has replaced amputation as the first choice for the treatment of bone tumors around knee. After tumor resection, there are a variety of reconstruction methods for us to choose, including autograft or allograft, inactivation and reimplantation, artificial prosthesis replacement, and allograft-prosthesis compound reconstruction. Compared with other reconstruction methods, artificial prosthesis reconstruction has some advantages: relatively simple, early weight bearing, fewer early complications, and good function in the early and mid-term follow-up. After decades of continuous improvements, the design of tumor prosthesis has reached a relatively mature stage, and the failure rate of prosthesis has also been declining year by year. However, artificial prostheses also have multiple complications such as infection, aseptic loosening, prosthetic breakage, and patients sometimes face the risk of revision or amputation. Therefore, clinicians need to deeply understand the characteristics of related complications and the principles of treatment.

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Section: Prosthetic Fixation Methodsmentioning

confidence: 99%

Application and Development of Megaprostheses in Limb Salvage for Bone Tumors Around the Knee Joint

Zhang

2022

Cancer Control

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“…The target proteins, including Bcl-2, Bax, Caspase 3, P53, β-actin, Akt, phosphor-AKT (p-Akt), P62, microtubule-associated protein 1-light chain 3 B (LC3B), and Beclin-1, were analyzed as described in our previous study. 38 The cells were also cultured in LDH@C2 extract for different durations (3,6,12, and 24 h), and the above-mentioned protein expression levels were detected.…”

Section: Cell Culture and Collection Of Extractsmentioning

confidence: 99%

“…Osteosarcoma (OS), which mainly occurs in children and adolescents, is a type of malignant bone tumor characterized by rapid development, a low degree of differentiation, and high metastases. , The 5-year survival rate of OS patients has gained 60–70% owing to progress in diagnosis, surgical protocols, and chemotherapeutic drugs. − Nevertheless, after the development of metastases, the 5-year survival rate sharply decreases to less than 20%. , The gold standard for OS therapy is neoadjuvant chemotherapy, in which patients receive preoperative chemotherapy to reduce the tumor size, surgery to remove the tumor and fill the defects with implants, and postoperative chemotherapy to prevent recurrence. − However, chemotherapy causes many side effects such as a decreased number of blood cells, damage to the immune system, and, most important, inhibition of bone regeneration around the prosthesis, which can induce implant failure. Therefore, the design and construction of implants with antitumor properties, which reduce the need for postoperative chemotherapy, and simultaneously, enhanced bone reconstruction, would be of great significance for OS therapy.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism Underlying the Action of a Celastrol-Loaded Layered Double Hydroxide-Coated Magnesium Alloy in Osteosarcoma Inhibition and Bone Regeneration

Cheng,

Shao,

Yin

et al. 2023

ACS Biomater. Sci. Eng.

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Osteosarcoma (OS) is a malignant bone tumor that threatens human health. Surgical removal of the tumor and followed by implantation with a graft is the golden standard for its clinical treatment. However, avoiding recurrence by enhancing the antitumor properties of the implants and improving osteogenesis around the implants remain a challenge. Here, we developed a layered double hydroxide (LDH)-coated magnesium (Mg) alloy and loaded it with celastrol. The celastrol-loaded Mg alloy exhibited enhanced corrosion resistance and sustained release of celastrol. In vitro cell culture suggested that the modified Mg alloy loaded with an appropriate amount of celastrol significantly inhibited the proliferation and migration of bone tumor cells while having little influence on normal cells. A mechanistic study revealed that the celastrol-loaded Mg alloy upregulated reactive oxygen species (ROS) generation in bone tumor cells, resulting in mitochondrial dysfunction due to reduced membrane potential, thereby inducing bone tumor cell apoptosis. Furthermore, it was found that celastrol-induced autophagy in tumor cells inhibited cell apoptosis in the initial 6 h. After ≥12 h of culture, inhibition of the PI3K-Akt-mTOR signaling pathway was noted, resulting in excessive autophagy in tumor cells, finally causing cell apoptosis. The celatsrol-loaded Mg alloy also exhibited effective antitumor properties in a subcutaneous tumor model. In vitro tartrate-resistant acid phosphatase (TRAP) staining and gene expression results revealed that the modified Mg alloy reduced the viability of osteoclasts, inducing a potential pathway for the increased bone regeneration around the modified Mg alloy seen in vivo. Together, the results of our study show that the celatsrol-loaded Mg alloy might be a promising implant for treating OS.

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Active Physical Exercise Improves Functional Knee Recovery and Quality of Life Without Increasing the Risk of Complication in Patients with Endoprosthetic Knee Replacement for Bone Tumor

Zhao

Cui

et al. 2023

J. of SCI. IN SPORT AND EXERCISE

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The risk factors for mechanical complication in endoprosthetic reconstruction of knee osteosarcoma

Cited by 3 publications

References 30 publications

Application and Development of Megaprostheses in Limb Salvage for Bone Tumors Around the Knee Joint

Application and Development of Megaprostheses in Limb Salvage for Bone Tumors Around the Knee Joint

Molecular Mechanism Underlying the Action of a Celastrol-Loaded Layered Double Hydroxide-Coated Magnesium Alloy in Osteosarcoma Inhibition and Bone Regeneration

Active Physical Exercise Improves Functional Knee Recovery and Quality of Life Without Increasing the Risk of Complication in Patients with Endoprosthetic Knee Replacement for Bone Tumor

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