The rising trend of coagulase-negative staphylococci in neonatal septicemia

Shivanna, Vijaya; Sunkappa, S R; Venkatesha, D

doi:10.4103/0377-4929.191806

Cited by 14 publications

(21 citation statements)

References 2 publications

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“…In a prospective study by Shivanna, et al, [3] carried out from July to August 2014 in a tertiary care hospital in India, among the 50 neonatal blood culture samples obtained, 30% (15/50) were blood culture positive. It was distributed as Gram-positive cocci 80% (12/15) and Gram-negative bacilli 20% (3/15).…”

Section: Resultsmentioning

confidence: 99%

“…Neonatal sepsis is often classified as early or late onset based on the age of the child [1]. With the high morbidity and mortality associated with neonatal sepsis, empirical treatment is essential and requires indepth knowledge of the bacterial spectrum and antibiotic susceptibility pattern prevalent in the hospital location [2,3,10]. However, despite the initiation of empirical treatment, neonatal sepsis still remains a vital cause of mortality and morbidity globally because of the non-specific clinical manifestations [4].…”

Section: Discussionmentioning

confidence: 99%

“…Neonatal sepsis is a systemic inflammatory response caused by bacterial production of toxins after gaining entry into the bloodstream and multiplying [1]. It is classified into the early-onset neonatal sepsis (≤ 72hrs) due to bacteria acquired before or during delivery, and lateonset neonatal sepsis (>72 hrs-28days) involving pathogens acquired after delivery [2,3]. Generally, it is a life-threatening case.…”

Section: Introductionmentioning

confidence: 99%

“…The isolation of Gram-positive cocci in neonatal sepsis has increased significantly in the last two decades, especially with the use of invasive medical devices and the onset of resistant organisms [3]. Coagulase-negative staphylococci have been identified as the common Gram-positive cocci in neonatal sepsis, especially in low birth weight infants [4,7].…”

Section: Introductionmentioning

confidence: 99%

“…These are closely associated with the mortality rate. Others include child health-care facilities, maternal nutrition, HIV infection, hygiene condition during labor and perinatal care [3,8]. Preterm infants having neonatal sepsis are at risk of developing complications due to poorly developed immunity.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Coagulase-Negative Staphylococci in Neonatal Sepsis

Grace¹,

Obaro²

2019

Clin Microbiol

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We sought to analyze the prevalence of neonatal sepsis based on eight selected articles published in 2016 and 2017 with details on the demographics, bacteria distribution, risk factors, antibacterial susceptibility and the rising isolation of Coagulase-negative staphylococci (CoNS) among other bacteria isolates. Early Onset Neonatal Sepsis (EONS) was prevalent in most of the studies than Late-Onset Neonatal Sepsis (LONS). The rate of CoNS isolation in neonatal blood cultures was significantly high with varying mortality, morbidity and methicillin-resistant CoNS observed. However, CoNS is still considered as a contaminant when the clinical course is not consistent with sepsis. The predominant species were Staphylococcus epidermidis, S. haemolyticus, S. hominis and S. capitis, which were being regarded as conditional pathogens or contaminants. Staphylococcus capitis NRCS-A clone was identified in 17 countries with marked multidrug resistance. High susceptibility of CoNS to linezolid and vancomycin were observed, except in S. capitis NRCS-A clone that showed treatment failure to aminoglycosides and vancomycin. Research on CoNS in neonatal sepsis will be a thriving area for years to come especially with its close association with hospital routine, assessing its pathogenic potential, the global spread of the multidrug-resistant NRCS-A clone of S. capitis and the introduction of vaccination opportunities. Adequate funding and collaboration of research effort will be required to address these key questions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Systematic Review of Coagulase-Negative Staphylococci in Neonatal Sepsis

Grace¹,

Obaro²

2019

Clin Microbiol

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The Validity of Positive Coagulase-Negative Staphylococcus Cultures for the Diagnosis of Sepsis in the Neonatal Unit

et al. 2022

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Background: Coagulase-negative Staphylococcus (CoNS), is the most frequent pathogen causing late onset sepsis (LOS) in neonatal intensive-care units (NICUs). Technical difficulties hinder blood culture (BC) collection and obtaining only one culture before initiating antibiotic therapy is common practice. We sought to assess specific clinical information and CoNS cultures for the diagnosis of true bacteremia in the NICU. Methods: This historical cohort study was conducted in NICUs at Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Clinical and laboratory data in every CoNS bacteremia were collected and compared between bacteremia groups: true-positive – two positive BCs; contaminant – one positive BC out of two; undefined – one BC obtained and found positive. Results: During 3.5 years, CoNS was isolated in 139 episodes. True-positive was identified in 44/139 (31.7%), contaminant in 42/139 (30.2%) and in 53/139 (38.1%) the event was undefined. Vancomycin treatment was more frequent in the true-positive and undefined groups than the contaminant group (100%, 90.6% and 73.8% respectively, p=0.001); treatment was also prolonged in these two groups (p<0.001). No clinical variables were associated with true bacteremia on multivariable analysis. Conclusions: Diagnosis should definitely be based on at least two positive BCs, despite objective difficulties in obtaining BCs in neonates.

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Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates

Adeghate

Juhász

Iván

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objectives. Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial translocation from the gastrointestinal tract. We aimed to examine similarities in coagulase-negative staphylococci (CoNS) strains found in the gastrointestinal tract and bloodstream in bacteremic neonates. Methods. CoNS strains isolated from blood cultures and perianal and pharyngeal swab samples of neonates from two neonatal intensive care units were investigated using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and pulsed-field gel electrophoresis. Molecular mass and genetic similarities of CoNS strains were compared. Results. Marked similarity was found in the molecular mass and genetic profile of examined CoNS isolates from blood cultures and perianal/pharyngeal samples. The percentage of neonates developing bacteremia following perianal and pharyngeal colonization by CoNS was significantly higher when compared to those colonized by Enterobacteriales species (p<0.0002). Conclusions. CoNS colonizing the gut may be a source of bacteremia in neonates. Enterobacteriales species do not contribute as significantly to bacteremia when compared to CoNS, and may be protective against gut mucosa-originated systemic infection.

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The rising trend of coagulase-negative staphylococci in neonatal septicemia

Cited by 14 publications

References 2 publications

A Systematic Review of Coagulase-Negative Staphylococci in Neonatal Sepsis

A Systematic Review of Coagulase-Negative Staphylococci in Neonatal Sepsis

The Validity of Positive Coagulase-Negative Staphylococcus Cultures for the Diagnosis of Sepsis in the Neonatal Unit

Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates

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