The Rising Trend in Seropositivity among the Diverse Population of Karachi-Possible Implication in SARS-Cov-2 Control

Rezwan, Faiza; Zaidi, Samreen; Danish, Asma; Khawaja, Shabnum; Imam, Mehjabeen; Hassan, J.E.; Waheed, Samra; Naz, Arshi; Borhany, Munira; Shamsi, Tahir

doi:10.36348/sjpm.2020.v05i12.005

Cited by 2 publications

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“…Table 1 characterizes the data extracted from each of the 33 studies included in this review [12–44]. Of the published studies, the vast majority (91%; 20/22) were published in clinical or public health journals, two were specifically published in transfusion medicine journals.…”

Section: Resultsmentioning

confidence: 99%

“…The scope of studies varied; the majority (76%; 25/33) provided regional estimates within countries. Approximately half of the studies (52%; 17/33) provided a single seroprevalence estimate [13–17, 19, 21, 26, 29, 31–33, 35, 38, 39, 41, 44]. Stratification by age and sex were most common (64%; 21/33), followed by region (48%; 16/33).…”

Section: Resultsmentioning

confidence: 99%

“…There was significant heterogeneity by methodological factors that influence seroprevalence estimates (Figure 5). Characterization of the blood donor populations varied; five studies did not report the age of donors sampled [16,23,38,39,41]. The scope of studies varied; the majority (76%; 25/33) provided regional estimates within Only two studies (Sweden and Brazil), adjusted their seroprevalence estimates for waning antibodies [23,43].…”

Section: Resultsmentioning

confidence: 99%

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Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

et al. 2021

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Background and Objectives: Blood donors are increasingly being recognized as an informative resource for surveillance. We aimed to review severe acute respiratory syndrome coronavirus 2 seroprevalence studies conducted among blood donors to investigate methodological biases and provide guidance for future research. Materials and Methods:We conducted a scoping review of peer-reviewed and preprint publications between January 2020 and January 2021. Two reviewers used standardized forms to extract seroprevalence estimates and data on methodology pertaining to population sampling, periodicity, assay characteristics, and antibody kinetics. National data on cumulative incidence and social distancing policies were extracted from publicly available sources and summarized.Results: Thirty-three studies representing 1,323,307 blood donations from 20 countries worldwide were included (sample sizes ranged from 22 to 953,926 donations).The majority of the studies (79%) reported seroprevalence rates <10% (ranging from 0% to 76% [after adjusting for waning antibodies]). Overall, less than 1 in 5 studies reported standardized seroprevalence rates to reflect the demographics of the general population. Stratification by age and sex were most common (64% of studies), followed by region (48%). A total of 52% of studies reported seroprevalence at a single time point. Overall, 27 unique assay combinations were identified, 55% of studies used a single assay and only 39% adjusted seroprevalence rates for imperfect test characteristics. Among the nationally representative studies, case detection was most underrepresented in Kenya (1:1264). Conclusion:By the end of 2020, seroprevalence rates were far from reaching herd immunity. In addition to differences in community transmission and diverse public health policies, study designs and methodology were likely contributing factors to seroprevalence heterogeneity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

et al. 2021

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“…There was significant heterogeneity by methodological factors that influence seroprevalence estimates (Table 1, summarized by Figure 5). Characterization of the blood donor populations varied; five studies did not report the age of donors sampled [16,23,38,39,41]. The scope of studies varied, the majority (76%; 25/33) provided regional estimates within countries.…”

Section: Resultsmentioning

confidence: 99%

Current challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies among blood donors: A scoping review

Saeed

Uzicanin

Lewin

et al. 2021

Preprint

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Background: Blood donors are increasingly being recognized as an informative resource for surveillance. We aimed to review and characterize SARS-CoV-2 seroprevalence studies conducted using blood donors to investigate methodology and provide guidance for future research. Methods: We conducted a scoping review of peer-reviewed and preprint publications between January 2020 to January 2021. Two reviewers used standardized forms to extract seroprevalence estimates and data on methodology pertaining to population sampling, periodicity, assay characteristics and antibody kinetics. National data on cumulative incidence and social distancing policies were extracted from publicly available sources and summarized. Results: Thirty-three studies representing 1,323,307 blood donations from 20 countries worldwide were included (sample size per study ranged from 22 to 953,926 donations). Seroprevalence rates ranged from 0% to 76% (after adjusting for waning antibodies). Overall, less than 1 in 5 studies reported standardized seroprevalence rates to reflect the demographics of the general population. Stratification by age and sex were most common (64% of studies), followed by region (48%). 52% of studies reported seroprevalence at a single time point. Overall, 27 unique assay combinations were identified, 55% of studies used a single assay and only 39% adjusted seroprevalence rates for imperfect test characteristics. Among the eight nationally representative studies case detection was most underrepresented in Kenya (1:1264). Conclusion: As of December 11, 2020, 79% of studies reported seroprevalence rates <10%; thresholds far from reaching herd immunity. In addition to differences in community transmission and diverse public health policies, study designs and methodology were likely contributing factors to seroprevalence heterogeneity.

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The Rising Trend in Seropositivity among the Diverse Population of Karachi-Possible Implication in SARS-Cov-2 Control

Cited by 2 publications

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Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

Current challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies among blood donors: A scoping review

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