The Rising Threat of Hepatocellular Carcinoma in the Middle East and North Africa Region: Results From Global Burden of Disease Study 2017

Sharafi, Heidar; Alavian, Seyed Moayed

doi:10.1002/cld.890

Cited by 27 publications

(24 citation statements)

References 20 publications

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“…Oncological disease of the liver is especially prevalent in Asia and more recently in North Africa, but also in so-called Western countries liver cancer is a growing concern [ 45 , 46 ]. Liver cancer often presents as a result of ongoing inflammatory processes caused by hepatitis B or C, alcohol, or fatty liver disease.…”

Section: Liver Cancermentioning

confidence: 99%

Drug Discovery in Liver Disease Using Kinome Profiling

Mamedov

Fuhler

et al. 2021

IJMS

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The liver is one of the most important organs, playing critical roles in maintaining biochemical homeostasis. Accordingly, disease of the liver is often debilitating and responsible for untold human misery. As biochemical nexus, with kinases being master regulators of cellular biochemistry, targeting kinase enzymes is an obvious avenue for treating liver disease. Development of such therapy, however, is hampered by the technical difficulty of obtaining comprehensive insight into hepatic kinase activity, a problem further compounded by the often unique aspects of hepatic kinase activities, which makes extrapolations from other systems difficult. This consideration prompted us to review the current state of the art with respect to kinome profiling approaches towards the hepatic kinome. We observe that currently four different approaches are available, all showing significant promise. Hence we postulate that insight into the hepatic kinome will quickly increase, leading to rational kinase-targeted therapy for different liver diseases.

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Section: Liver Cancermentioning

confidence: 99%

Drug Discovery in Liver Disease Using Kinome Profiling

Mamedov

Fuhler

et al. 2021

IJMS

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“…Recent reports demonstrate that the incidence of HCC has increased sharply in Egypt through the last 5-10 years (Sharafi and Alavian 2020)…”

Section: Epidemiology Of Hccmentioning

confidence: 99%

Nano-formulations for Different Treatment Modalities to Overcome Multi Drug Resistance in Hepatocellular Carcinoma

Mansour

ElBatsh

Badawy

et al. 2021

Records of Pharmaceutical and Biomedical Sciences

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“…Among females, the regions with the highest ASR were Riyadh (4.9 per 100,000), the Eastern region (2.8 per 100,000), and the Tabuk region (2.6 per 100,000). [ 8 ]…”

Section: Epidemiology and Etiologymentioning

confidence: 99%

Saudi Association for the Study of Liver diseases and Transplantation practice guidelines on the diagnosis and management of hepatocellular carcinoma

Alqahtani

Sanai

Alolayan

et al. 2020

Saudi J Gastroenterol

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The Rising Threat of Hepatocellular Carcinoma in the Middle East and North Africa Region: Results From Global Burden of Disease Study 2017

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/14-6-reading-sharafi a video presentation of this article

Cited by 27 publications

References 20 publications

Drug Discovery in Liver Disease Using Kinome Profiling

Drug Discovery in Liver Disease Using Kinome Profiling

Nano-formulations for Different Treatment Modalities to Overcome Multi Drug Resistance in Hepatocellular Carcinoma

Saudi Association for the Study of Liver diseases and Transplantation practice guidelines on the diagnosis and management of hepatocellular carcinoma

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