The rise of the hepatitis E virus

Pereira, Juan Pablo Scarano; Martinino, Alessandro; Roque–Afonso, Anne–Marie

doi:10.1016/j.jhep.2021.04.038

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Subsequently, it infects hepatocytes, and then spreads into the bloodstream, where it targets extrahepatic cells, including nerve cells. Upon release from the apical side, HEV is excreted through feces and urine [ 14 ]. By the 8th day of the disease's progression, varying levels of HEV were detected in the feces and peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis E virus and Klebsiella pneumoniae co-infection detected by metagenomics next-generation sequencing in a patient with central nervous system and bloodstream Infection: a case report

Cui,

Sun,

Xue

et al. 2024

BMC Infect Dis

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Background Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide with major prevalence in the developing countries and can cause extrahepatic disease including the nervous system. Central nervous system infections caused by HEV are rare and caused by HEV together with other bacteria are even rarer. Case presentation A 68-year-old man was admitted to the hospital due to a headache lasting for 6 days and a fever for 3 days. Lab tests showed significantly raised indicators of inflammation, cloudy cerebrospinal fluid, and liver dysfunction. Hepatitis E virus and Klebsiella pneumoniae were identified in the blood and cerebrospinal fluid using metagenomic next-generation sequencing. The patient received meropenem injection to treat K. pneumoniae infection, isoglycoside magnesium oxalate injection and polyene phosphatidylcholine injection for liver protection. After ten days of treatment, the patient improved and was discharged from the hospital. Conclusion Metagenomic next-generation sequencing, which can detect various types of microorganisms, is powerful for identifying complicated infections.

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Section: Discussionmentioning

confidence: 99%

Hepatitis E virus and Klebsiella pneumoniae co-infection detected by metagenomics next-generation sequencing in a patient with central nervous system and bloodstream Infection: a case report

Cui,

Sun,

Xue

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…Both forms of the virus are infectious and allow HEV dissemination. Importantly, the quasienvelope allows for the evasion of the host immune response [ 10 ] and may facilitate the dissemination of the virus; this might be related to the distribution of the virus in different tissues and the multiple extrahepatic manifestations related to the infection. In humans, the progression of HEV infection in the liver is restricted by host immunity [ 11 ]; however, the exact mechanisms responsible for the diverse outcomes associated with the infection and the pathophysiological mechanisms behind the development of extrahepatic manifestations remain to be elucidated.…”

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confidence: 99%