The Rise in Appendiceal Cancer Incidence: 2000–2009

Marmor, Schelomo; Portschy, Pamela R.; Tuttle, Todd M.; Virnig, Beth A

doi:10.1007/s11605-014-2726-7

Cited by 150 publications

(152 citation statements)

References 16 publications

(15 reference statements)

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“…Although the incidence has been increasing for over a decade, 1 several issues have made completing clinical trials difficult 20 . While prospective randomized trials have been attempted in the past (NCT00052962), none, at any stage, had completed planned accrual.…”

Section: Discussionmentioning

confidence: 99%

“…Appendiceal cancer represents a rare neoplasm which has been increasing in incidence 1 . There are no established screening systems for appendiceal cancer, so presents with peritoneal dissemination it all too frequently 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…There are no established screening systems for appendiceal cancer, so presents with peritoneal dissemination it all too frequently 1,2 . Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has become an accepted and promising therapy for cases of peritoneal dissemination from appendiceal primary lesions.…”

Section: Introductionmentioning

confidence: 99%

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A Multicenter Randomized Trial to Evaluate Hematologic Toxicities after Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin or Mitomycin in Patients with Appendiceal Tumors

Levine

Votanopoulos

Shen

et al. 2018

Journal of the American College of Surgeons

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Background Appendiceal cancer is a rare disease, which has proven difficult to study in prospective trials. Cytoreductive surgery with HIPEC is an established therapy for peritoneal dissemination from appendiceal cancer. The optimal chemotherapeutic agent to use in the HIPEC is not clear. Mitomycin has long been the utilized, however our previous phase I experience, and European retrospective studies suggest oxaliplatin as an alternative. Therefore, we initiated a multicenter randomized trial to compare mitomycin to oxaliplatin HIPEC for appendiceal cancer. Study Design Patients with mucinous appendiceal neoplasms with evidence of peritoneal dissemination underwent cytoreductive surgery and HIPEC using a closed technique for 120 minutes. Patients were randomized intraoperatively to HIPEC using mitomycin(40mg) or oxaliplatin(200mg/M2). Follow up included daily blood counts and toxicity assessments. Results 121 analytic patients were accrued to the trial over 6 years at 3 sites. The cases were 57% female, with an average age of 55.3 years(range 22-82). The disease was low grade in 77% and high grade in 23%. There were no significant differences in hemoglobin or platelet counts. The WBC was significantly lower in the mitomycin group between postoperative days 5-10. Overall and disease free survival at 3 years were similar at 83.7% and 66.8% for mitomycin and 86.9% and 64.8% for oxaliplatin. Conclusions This represents the first completed prospective randomized trial for cancer of the appendix, and shows that multicenter trials for this disease are feasible. Both mitomycin and oxaliplatin are associated with minor hematologic toxicity. However, mitomycin has slightly higher hematologic toxicity and lower QOL than oxaliplatin in HIPEC. Consequently, oxaliplatin may be preferred in patients with leukopenia and mitomycin preferred in patients with thrombocytopenia due to prior chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Multicenter Randomized Trial to Evaluate Hematologic Toxicities after Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin or Mitomycin in Patients with Appendiceal Tumors

Levine

Votanopoulos

Shen

et al. 2018

Journal of the American College of Surgeons

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“…The tumor itself is not aggressive but has the potential for rupture and spread throughout the peritoneum, which carries a poor prognosis [2]. This cancer is most often diagnosed following appendectomy for suspected acute appendicitis [3].…”

Section: Introductionmentioning

confidence: 99%

Primary adenocarcinoma of the appendix in a child: A case report

et al. 2018

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BackgroundPrimary adenocarcinoma of the appendix is a rare disease in clinical practice. Moreover, primary adenocarcinoma of the appendix in the pediatric age group is even rarer with very little cases being published. Here, we report a case of primary adenocarcinoma of the appendix with local invasion into adjacent organs in a child who was initially diagnosed as having an acute appendicitis.Case presentationA 13-year-old girl presented with abdominal pain of 3-month duration. Imaging study showed a mass including the fecalith that occupied her pelvic and right lower abdominal cavity. Drainage of the abscess and appendectomy were performed by the preoperative diagnosis of an acute appendicitis with an appendiceal mass. Postoperative histopathological examinations revealed the appendiceal adenocarcinoma. She then received the whole mass resection, ileocecal resection with lymph node dissection. The masses were tightly adherent with infiltration into the sigmoid colon, uterus, and right ovary. These organs were all dissected, and subsequent sigmoid colostomy was performed. We preserved the left ovary for her fertility. The pathological findings demonstrated negative margins and no lymph node invasions, and final pathological stage was pT4(SI)N0M0, stage II. After the operation, she received the chemotherapy with 6 cycles of 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (mFOLFOX6) and subsequent 6 cycles of simplified LV and 5-FU (sLV5FU2). The patient is doing well till today on follow-up without progression of the disease 5 years after the operation.ConclusionPrimary adenocarcinoma of the appendix is exceedingly rare in children. In this report, we described one of the youngest primary adenocarcinomas of an appendix case ever reported. When encountering atypical cases of the appendicitis, we should consider the possibility of primary adenocarcinoma of the appendix as it has an extremely poor prognosis and is usually diagnosed in advanced stages.

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“…La sobrevida a los 5 años depende del tipo de cáncer pero se tiene una media del 48%. (3) Como síntoma principal se tiene un cuadro similar a la apendicitis, además de ruptura de apéndice. También se puede presentar en asociación a un absceso apendicular, masa abdominal palpable, obstrucción intestinal y pseudomixoma peritoneal.…”

Section: Introductionunclassified

Cáncer de Apéndice: Revisión Bibliográfica

Jiménez

Mora²

2018

RC_UCR-HSJD

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Palabras clave Key wordsEl cáncer de apéndice es una entidad patológica poco común, donde la mayoría de diagnósticos se derivan de un hallazgo incidental post apendectomías. Debido a ser poco conocida, el tratamiento prevalece controversial. Desde el año 2000 se ha visto un aumento de la incidencia, por lo cual es una patología de importancia para estudio según tendencias de su comporta-miento.Appendix cancer is a rare pathological entity, where the majority of diagnoses are derived from an incidental finding after appendecto-mies. Due to being little known, the treatment prevails controversial. Since 2000, there has been an increase in incidence, which is why it is a pathology of importance for study according to trends in its behavior.

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The Rise in Appendiceal Cancer Incidence: 2000–2009

Cited by 150 publications

References 16 publications

A Multicenter Randomized Trial to Evaluate Hematologic Toxicities after Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin or Mitomycin in Patients with Appendiceal Tumors

A Multicenter Randomized Trial to Evaluate Hematologic Toxicities after Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin or Mitomycin in Patients with Appendiceal Tumors

Primary adenocarcinoma of the appendix in a child: A case report

Cáncer de Apéndice: Revisión Bibliográfica

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